Arnold MB - Search Results

1

Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists.

Zarrinmayeh H, Nunes AM, Ornstein PL, Zimmerman DM, Arnold MB, Schober DA, Gackenheimer SL, Bruns RF, Hipskind PA, Britton TC, Cantrell BE, Gehlert DR. Zarrinmayeh H, et al. Among authors: arnold mb. J Med Chem. 1998 Jul 16;41(15):2709-19. doi: 10.1021/jm9706630. J Med Chem. 1998. PMID: 9667962

2

NMDA antagonist activity of (+/-)-(2SR,4RS)-4-(1H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid resides with the (-)-2R,4S-isomer.

Ornstein PL, Schoepp DD, Arnold MB, Jones ND, Deeter JB, Lodge D, Leander JD. Ornstein PL, et al. Among authors: arnold mb. J Med Chem. 1992 Aug 21;35(17):3111-5. doi: 10.1021/jm00095a004. J Med Chem. 1992. PMID: 1387167

3

6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists.

Ornstein PL, Schoepp DD, Arnold MB, Augenstein NK, Lodge D, Millar JD, Chambers J, Campbell J, Paschal JW, Zimmerman DM, et al. Ornstein PL, et al. Among authors: arnold mb. J Med Chem. 1992 Sep 18;35(19):3547-60. doi: 10.1021/jm00097a012. J Med Chem. 1992. PMID: 1404235

4

4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.

Ornstein PL, Schoepp DD, Arnold MB, Leander JD, Lodge D, Paschal JW, Elzey T. Ornstein PL, et al. Among authors: arnold mb. J Med Chem. 1991 Jan;34(1):90-7. doi: 10.1021/jm00105a016. J Med Chem. 1991. PMID: 1825117

5

(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist.

Ornstein PL, Arnold MB, Augenstein NK, Lodge D, Leander JD, Schoepp DD. Ornstein PL, et al. Among authors: arnold mb. J Med Chem. 1993 Jul 9;36(14):2046-8. doi: 10.1021/jm00066a016. J Med Chem. 1993. PMID: 8393116 No abstract available.

6

(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.

Ornstein PL, Arnold MB, Allen NK, Leander JD, Tizzano JP, Lodge D, Schoepp DD. Ornstein PL, et al. Among authors: arnold mb. J Med Chem. 1995 Dec 8;38(25):4885-90. doi: 10.1021/jm00025a005. J Med Chem. 1995. PMID: 8523401

7

Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution.

Ornstein PL, Arnold MB, Allen NK, Bleisch T, Borromeo PS, Lugar CW, Leander JD, Lodge D, Schoepp DD. Ornstein PL, et al. Among authors: arnold mb. J Med Chem. 1996 May 24;39(11):2219-31. doi: 10.1021/jm950912p. J Med Chem. 1996. PMID: 8667365

8

Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity.

Ornstein PL, Arnold MB, Allen NK, Bleisch T, Borromeo PS, Lugar CW, Leander JD, Lodge D, Schoepp DD. Ornstein PL, et al. Among authors: arnold mb. J Med Chem. 1996 May 24;39(11):2232-44. doi: 10.1021/jm950913h. J Med Chem. 1996. PMID: 8667366

9

2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution.

Ornstein PL, Bleisch TJ, Arnold MB, Wright RA, Johnson BG, Schoepp DD. Ornstein PL, et al. Among authors: arnold mb. J Med Chem. 1998 Jan 29;41(3):346-57. doi: 10.1021/jm970497w. J Med Chem. 1998. PMID: 9464366

10

2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.

Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH, Wright RA, Johnson BG, Tizzano JP, Helton DR, Kallman MJ, Schoepp DD, Hérin M. Ornstein PL, et al. Among authors: arnold mb. J Med Chem. 1998 Jan 29;41(3):358-78. doi: 10.1021/jm970498o. J Med Chem. 1998. PMID: 9464367

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