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Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice.
Anghel N, Winzer PA, Imhof D, Müller J, Langa X, Rieder J, Barrett LK, Vidadala RSR, Huang W, Choi R, Hulverson MA, Whitman GR, Arnold SL, Van Voorhis WC, Ojo KK, Maly DJ, Fan E, Hemphill A. Anghel N, et al. Among authors: arnold sl. Int J Antimicrob Agents. 2020 Sep;56(3):106099. doi: 10.1016/j.ijantimicag.2020.106099. Epub 2020 Jul 21. Int J Antimicrob Agents. 2020. PMID: 32707170 Free PMC article.
Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.
Schaefer DA, Betzer DP, Smith KD, Millman ZG, Michalski HC, Menchaca SE, Zambriski JA, Ojo KK, Hulverson MA, Arnold SL, Rivas KL, Vidadala RS, Huang W, Barrett LK, Maly DJ, Fan E, Van Voorhis WC, Riggs MW. Schaefer DA, et al. Among authors: arnold sl. J Infect Dis. 2016 Dec 15;214(12):1856-1864. doi: 10.1093/infdis/jiw488. Epub 2016 Oct 17. J Infect Dis. 2016. PMID: 27923949 Free PMC article.
Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.
Van Voorhis WC, Doggett JS, Parsons M, Hulverson MA, Choi R, Arnold SLM, Riggs MW, Hemphill A, Howe DK, Mealey RH, Lau AOT, Merritt EA, Maly DJ, Fan E, Ojo KK. Van Voorhis WC, et al. Exp Parasitol. 2017 Sep;180:71-83. doi: 10.1016/j.exppara.2017.01.001. Epub 2017 Jan 5. Exp Parasitol. 2017. PMID: 28065755 Free PMC article. Review.
Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.
Hulverson MA, Vinayak S, Choi R, Schaefer DA, Castellanos-Gonzalez A, Vidadala RSR, Brooks CF, Herbert GT, Betzer DP, Whitman GR, Sparks HN, Arnold SLM, Rivas KL, Barrett LK, White AC Jr, Maly DJ, Riggs MW, Striepen B, Van Voorhis WC, Ojo KK. Hulverson MA, et al. J Infect Dis. 2017 Apr 15;215(8):1275-1284. doi: 10.1093/infdis/jix120. J Infect Dis. 2017. PMID: 28329187 Free PMC article.
Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis.
Hulverson MA, Choi R, Arnold SLM, Schaefer DA, Hemphill A, McCloskey MC, Betzer DP, Müller J, Vidadala RSR, Whitman GR, Rivas KL, Barrett LK, Hackman RC, Love MS, McNamara CW, Shaughnessy TK, Kondratiuk A, Kurnick M, Banfor PN, Lynch JJ, Freiberg GM, Kempf DJ, Maly DJ, Riggs MW, Ojo KK, Van Voorhis WC. Hulverson MA, et al. Int J Parasitol. 2017 Oct;47(12):753-763. doi: 10.1016/j.ijpara.2017.08.006. Epub 2017 Sep 9. Int J Parasitol. 2017. PMID: 28899690 Free PMC article.
7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.
Vidadala RSR, Golkowski M, Hulverson MA, Choi R, McCloskey MC, Whitman GR, Huang W, Arnold SLM, Barrett LK, Fan E, Merritt EA, Van Voorhis WC, Ojo KK, Maly DJ. Vidadala RSR, et al. ACS Infect Dis. 2018 Apr 13;4(4):516-522. doi: 10.1021/acsinfecdis.7b00224. Epub 2018 Mar 16. ACS Infect Dis. 2018. PMID: 29522315 Free PMC article.
Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis.
Lee S, Ginese M, Beamer G, Danz HR, Girouard DJ, Chapman-Bonofiglio SP, Lee M, Hulverson MA, Choi R, Whitman GR, Ojo KK, Arnold SLM, Van Voorhis WC, Tzipori S. Lee S, et al. Antimicrob Agents Chemother. 2018 Jun 26;62(7):e00147-18. doi: 10.1128/AAC.00147-18. Print 2018 Jul. Antimicrob Agents Chemother. 2018. PMID: 29661877 Free PMC article.
Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.
Hulverson MA, Bruzual I, McConnell EV, Huang W, Vidadala RSR, Choi R, Arnold SLM, Whitman GR, McCloskey MC, Barrett LK, Rivas KL, Scheele S, DeRocher AE, Parsons M, Ojo KK, Maly DJ, Fan E, Van Voorhis WC, Doggett JS. Hulverson MA, et al. J Infect Dis. 2019 Apr 16;219(9):1464-1473. doi: 10.1093/infdis/jiy664. J Infect Dis. 2019. PMID: 30423128 Free PMC article.
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.
Buckner FS, Ranade RM, Gillespie JR, Shibata S, Hulverson MA, Zhang Z, Huang W, Choi R, Verlinde CLMJ, Hol WGJ, Ochida A, Akao Y, Choy RKM, Van Voorhis WC, Arnold SLM, Jumani RS, Huston CD, Fan E. Buckner FS, et al. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02061-18. doi: 10.1128/AAC.02061-18. Print 2019 Apr. Antimicrob Agents Chemother. 2019. PMID: 30745384 Free PMC article.
70 results