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The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Arold S, Franken P, Strub MP, Hoh F, Benichou S, Benarous R, Dumas C. Arold S, et al. Structure. 1997 Oct 15;5(10):1361-72. doi: 10.1016/s0969-2126(97)00286-4. Structure. 1997. PMID: 9351809
GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin.
Schmalzigaug R, Garron ML, Roseman JT, Xing Y, Davidson CE, Arold ST, Premont RT. Schmalzigaug R, et al. Cell Signal. 2007 Aug;19(8):1733-44. doi: 10.1016/j.cellsig.2007.03.010. Epub 2007 Mar 30. Cell Signal. 2007. PMID: 17467235 Free PMC article.
Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain.
Hoellerer MK, Noble ME, Labesse G, Campbell ID, Werner JM, Arold ST. Hoellerer MK, et al. Structure. 2003 Oct;11(10):1207-17. doi: 10.1016/j.str.2003.08.010. Structure. 2003. PMID: 14527389
Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells.
Kadaré G, Gervasi N, Brami-Cherrier K, Blockus H, El Messari S, Arold ST, Girault JA. Kadaré G, et al. J Biol Chem. 2015 Jan 2;290(1):478-91. doi: 10.1074/jbc.M114.593632. Epub 2014 Nov 12. J Biol Chem. 2015. PMID: 25391654 Free PMC article.
Structural basis for the interaction between focal adhesion kinase and CD4.
Garron ML, Arthos J, Guichou JF, McNally J, Cicala C, Arold ST. Garron ML, et al. J Mol Biol. 2008 Feb 1;375(5):1320-8. doi: 10.1016/j.jmb.2007.11.040. Epub 2007 Nov 22. J Mol Biol. 2008. PMID: 18078954
Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.
Kim JJ, Lorenz R, Arold ST, Reger AS, Sankaran B, Casteel DE, Herberg FW, Kim C. Kim JJ, et al. Structure. 2016 May 3;24(5):710-720. doi: 10.1016/j.str.2016.03.009. Epub 2016 Apr 7. Structure. 2016. PMID: 27066748 Free PMC article.
The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.
Arold ST, Ulmer TS, Mulhern TD, Werner JM, Ladbury JE, Campbell ID, Noble ME. Arold ST, et al. J Biol Chem. 2001 May 18;276(20):17199-205. doi: 10.1074/jbc.M011185200. Epub 2001 Feb 2. J Biol Chem. 2001. PMID: 11278857
Searching for specificity in SH domains.
Ladbury JE, Arold S. Ladbury JE, et al. Chem Biol. 2000 Jan;7(1):R3-8. doi: 10.1016/s1074-5521(00)00067-3. Chem Biol. 2000. PMID: 10662684 Review.
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