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Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.
Lissanu Deribe Y, Shi Y, Rai K, Nezi L, Amin SB, Wu CC, Akdemir KC, Mahdavi M, Peng Q, Chang QE, Hornigold K, Arold ST, Welch HC, Garraway LA, Chin L. Lissanu Deribe Y, et al. Among authors: arold st. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1296-305. doi: 10.1073/pnas.1513801113. Epub 2016 Feb 16. Proc Natl Acad Sci U S A. 2016. PMID: 26884185 Free PMC article.
A landscape of driver mutations in melanoma.
Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP, Nickerson E, Auclair D, Li L, Place C, Dicara D, Ramos AH, Lawrence MS, Cibulskis K, Sivachenko A, Voet D, Saksena G, Stransky N, Onofrio RC, Winckler W, Ardlie K, Wagle N, Wargo J, Chong K, Morton DL, Stemke-Hale K, Chen G, Noble M, Meyerson M, Ladbury JE, Davies MA, Gershenwald JE, Wagner SN, Hoon DS, Schadendorf D, Lander ES, Gabriel SB, Getz G, Garraway LA, Chin L. Hodis E, et al. Among authors: arold st. Cell. 2012 Jul 20;150(2):251-63. doi: 10.1016/j.cell.2012.06.024. Cell. 2012. PMID: 22817889 Free PMC article.
H-NS forms a superhelical protein scaffold for DNA condensation.
Arold ST, Leonard PG, Parkinson GN, Ladbury JE. Arold ST, et al. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15728-32. doi: 10.1073/pnas.1006966107. Epub 2010 Aug 23. Proc Natl Acad Sci U S A. 2010. PMID: 20798056 Free PMC article.
HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer.
Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q, Huang TH, Hsu JM, Brady SW, Bartholomeusz C, Ladbury JE, Stone S, Yu D, Hung MC, Esteva FJ. Boulbes DR, et al. Among authors: arold st. Mol Oncol. 2015 Mar;9(3):586-600. doi: 10.1016/j.molonc.2014.10.011. Epub 2014 Nov 11. Mol Oncol. 2015. PMID: 25435280 Free PMC article.
DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway.
Adam L, San Lucas FA, Fowler R, Yu Y, Wu W, Liu Y, Wang H, Menter D, Tetzlaff MT, Ensor J Jr, Manyam G, Arold ST, Huff C, Kopetz S, Scheet P, Overman MJ. Adam L, et al. Among authors: arold st. Clin Cancer Res. 2019 Jan 15;25(2):641-651. doi: 10.1158/1078-0432.CCR-18-1480. Epub 2018 Oct 23. Clin Cancer Res. 2019. PMID: 30352910 Free PMC article.
Chromatin phosphoproteomics unravels a function for AT-hook motif nuclear localized protein AHL13 in PAMP-triggered immunity.
Rayapuram N, Jarad M, Alhoraibi HM, Bigeard J, Abulfaraj AA, Völz R, Mariappan KG, Almeida-Trapp M, Schlöffel M, Lastrucci E, Bonhomme L, Gust AA, Mithöfer A, Arold ST, Pflieger D, Hirt H. Rayapuram N, et al. Among authors: arold st. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2004670118. doi: 10.1073/pnas.2004670118. Proc Natl Acad Sci U S A. 2021. PMID: 33419940 Free PMC article.
MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours.
Perlman EJ, Gadd S, Arold ST, Radhakrishnan A, Gerhard DS, Jennings L, Huff V, Guidry Auvil JM, Davidsen TM, Dome JS, Meerzaman D, Hsu CH, Nguyen C, Anderson J, Ma Y, Mungall AJ, Moore RA, Marra MA, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Gastier-Foster JM, Ross N, Smith MA. Perlman EJ, et al. Among authors: arold st. Nat Commun. 2015 Dec 4;6:10013. doi: 10.1038/ncomms10013. Nat Commun. 2015. PMID: 26635203 Free PMC article.
173 results