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Reversal of P-glycoprotein-mediated multidrug resistance by diallyl sulfide in K562 leukemic cells and in mouse liver.
Arora A, Seth K, Shukla Y. Arora A, et al. Carcinogenesis. 2004 Jun;25(6):941-9. doi: 10.1093/carcin/bgh060. Epub 2004 Jan 16. Carcinogenesis. 2004. PMID: 14729595
A non-toxic concentration of DAS (8.75 x 10(-3) M) enhanced the cytotoxic effects of VBL and another vinca alkaloid, VCR, time dependently in VBL-resistant human leukemia (K562/R10) cells but had no effect on the parent (K562/S) cells. ...The above features thus indicate t
A non-toxic concentration of DAS (8.75 x 10(-3) M) enhanced the cytotoxic effects of VBL and another vinca alkaloid, VCR, time depend
Involvement of multiple signaling pathways in diallyl sulfide mediated apoptosis in mouse skin tumors.
Kalra N, Arora A, Shukla Y. Kalra N, et al. Among authors: arora a. Asian Pac J Cancer Prev. 2006 Oct-Dec;7(4):556-62. Asian Pac J Cancer Prev. 2006. PMID: 17250426
Diallyl sulfide (DAS), a naturally occurring organosulfide, present in garlic, is reported to have pleiotropic biological effects. ...Thus, our results confirm that DAS can adopt a multi-prong strategy to target multiple signaling pathways leading to induction of ap …
Diallyl sulfide (DAS), a naturally occurring organosulfide, present in garlic, is reported to have pleiotropic biological effects. .. …
Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin.
Arora A, Kalra N, Shukla Y. Arora A, et al. Cancer Lett. 2006 Oct 8;242(1):28-36. doi: 10.1016/j.canlet.2005.10.049. Epub 2006 Jan 30. Cancer Lett. 2006. PMID: 16448747
Diallyl sulfide (DAS), a naturally occurring organosulfide, present in garlic, is known to possess pleiotropic biological effects. DAS is known to inhibit chemically induced tumors in a number of animal models. The chemopreventive properties of DAS seem to occur thr …
Diallyl sulfide (DAS), a naturally occurring organosulfide, present in garlic, is known to possess pleiotropic biological effects. DA …
Modulation of P-glycoprotein-mediated multidrug resistance in K562 leukemic cells by indole-3-carbinol.
Arora A, Seth K, Kalra N, Shukla Y. Arora A, et al. Toxicol Appl Pharmacol. 2005 Feb 1;202(3):237-43. doi: 10.1016/j.taap.2004.06.017. Toxicol Appl Pharmacol. 2005. PMID: 15667829
P-glycoprotein (P-gp) encoded by the mdr gene is a highly conserved protein, acts as a multidrug transporter, and has a major role in multiple drug resistance (MDR). ...The above features thus indicate that I3C could be used as a novel modulator of P-g …
P-glycoprotein (P-gp) encoded by the mdr gene is a highly conserved protein, acts as a multidrug transporter, and has a
Chemopreventive effect of indole-3-carbinol on induction of preneoplastic altered hepatic foci.
Shukla Y, Kalra N, Katiyar S, Siddiqui IA, Arora A. Shukla Y, et al. Among authors: arora a. Nutr Cancer. 2004;50(2):214-20. doi: 10.1207/s15327914nc5002_12. Nutr Cancer. 2004. PMID: 15623469
Indole-3-carbinol (I3C) is a cleavage product of glucobrassicanin, a natural compound present in a wide variety of plant food substances including members of the family Cruciferae. ...The recovery of altered levels of these biomarkers was of comparatively hig …
Indole-3-carbinol (I3C) is a cleavage product of glucobrassicanin, a natural compound present in a wide variety of plan …
Modulation of p53 in 7,12-dimethylbenz[a]anthracene-induced skin tumors by diallyl sulfide in Swiss albino mice.
Arora A, Siddiqui IA, Shukla Y. Arora A, et al. Mol Cancer Ther. 2004 Nov;3(11):1459-66. Mol Cancer Ther. 2004. PMID: 15542785
In the present study, modulation in p53 expression by topical application of DAS was recorded in 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin tumors in Swiss albino mice. ...Thus, DAS can be a potential chemopreventive agent against skin tumor development....
In the present study, modulation in p53 expression by topical application of DAS was recorded in 7,12-dimethylbenz[a]anthracene (DMBA …
Protective effects of indole-3-carbinol on cyclophosphamide-induced clastogenecity in mouse bone marrow cells.
Shukla Y, Srivastava B, Arora A, Chauhan LK. Shukla Y, et al. Among authors: arora a. Hum Exp Toxicol. 2004 May;23(5):245-50. doi: 10.1191/0960327104ht441oa. Hum Exp Toxicol. 2004. PMID: 15222402
In the present study, the antimutagenic potential of I3C has been evaluated using in vivo chromosomal aberration (CA) assay as a cytogenetic end point. ...The results revealed a significant inhibition in the frequencies of CP-induced CAs and aberrant cells in bone m …
In the present study, the antimutagenic potential of I3C has been evaluated using in vivo chromosomal aberration (CA) assay as a cyto …
Suppression of altered hepatic foci development by curcumin in wistar rats.
Shukla Y, Arora A. Shukla Y, et al. Among authors: arora a. Nutr Cancer. 2003;45(1):53-9. doi: 10.1207/S15327914NC4501_7. Nutr Cancer. 2003. PMID: 12791505
Curcumin, a yellow pigment of turmeric (Curcuma longa), is a commonly used spice and a coloring agent in foods, drugs, and cosmetics. ...In the present study the effect of curcumin on the development of altered hepatic foci (AHF), by using a medium ter …
Curcumin, a yellow pigment of turmeric (Curcuma longa), is a commonly used spice and a coloring agent in foods, drugs, …
Enhancing effects of mustard oil on preneoplastic hepatic foci development in Wistar rats.
Shukla Y, Arora A. Shukla Y, et al. Among authors: arora a. Hum Exp Toxicol. 2003 Feb;22(2):51-5. doi: 10.1191/0960327103ht338oa. Hum Exp Toxicol. 2003. PMID: 12693827
Mustard oil, which is extensively used in India and elsewhere as a flying and cooking medium, is reported to induce an inflammatory response. ...A significant decrease in the relative and absolute liver weight of mustard oil-exposed rats was recorded. The results re …
Mustard oil, which is extensively used in India and elsewhere as a flying and cooking medium, is reported to induce an inflammatory r …
Induction of apoptosis by diallyl sulfide in DMBA-induced mouse skin tumors.
Arora A, Shukla Y. Arora A, et al. Nutr Cancer. 2002;44(1):89-94. doi: 10.1207/S15327914NC441_12. Nutr Cancer. 2002. PMID: 12672645
Diallyl sulfide (DAS), an organosulfur compound in garlic, has received increasing attention as a potential cancer-chemopreventive agent. ...Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay of skin tumors of DAS-supplemented animals showed a
Diallyl sulfide (DAS), an organosulfur compound in garlic, has received increasing attention as a potential cancer-chemopreventive ag …
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