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Fusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells.
Arora N, Leppla SH. Arora N, et al. Infect Immun. 1994 Nov;62(11):4955-61. doi: 10.1128/IAI.62.11.4955-4961.1994. Infect Immun. 1994. PMID: 7927776 Free PMC article.
Previous work showed that residues 1 to 254 of anthrax toxin lethal factor (LF1-254) are sufficient for binding to the protective antigen component of the toxin and that portions of Pseudomonas exotoxin A fused to LF1-254 are efficiently translocated to the cytosol of eukaryotic …
Previous work showed that residues 1 to 254 of anthrax toxin lethal factor (LF1-254) are sufficient for binding to the protective antigen co …
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