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ADAM17 as a therapeutic target in multiple diseases.
Arribas J, Esselens C. Arribas J, et al. Curr Pharm Des. 2009;15(20):2319-35. doi: 10.2174/138161209788682398. Curr Pharm Des. 2009. PMID: 19601834 Review.
Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17.
Zatovicova M, Sedlakova O, Svastova E, Ohradanova A, Ciampor F, Arribas J, Pastorek J, Pastorekova S. Zatovicova M, et al. Br J Cancer. 2005 Nov 28;93(11):1267-76. doi: 10.1038/sj.bjc.6602861. Br J Cancer. 2005. PMID: 16278664 Free PMC article.
ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorin.
Malapeira J, Esselens C, Bech-Serra JJ, Canals F, Arribas J. Malapeira J, et al. Oncogene. 2011 Apr 21;30(16):1912-22. doi: 10.1038/onc.2010.565. Epub 2010 Dec 20. Oncogene. 2011. PMID: 21170088
Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing.
Merlos-Suárez A, Fernández-Larrea J, Reddy P, Baselga J, Arribas J. Merlos-Suárez A, et al. J Biol Chem. 1998 Sep 18;273(38):24955-62. doi: 10.1074/jbc.273.38.24955. J Biol Chem. 1998. PMID: 9733803
Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme.
Merlos-Suárez A, Ruiz-Paz S, Baselga J, Arribas J. Merlos-Suárez A, et al. J Biol Chem. 2001 Dec 21;276(51):48510-7. doi: 10.1074/jbc.M103488200. Epub 2001 Oct 12. J Biol Chem. 2001. PMID: 11600492
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.
Georgilis A, Klotz S, Hanley CJ, Herranz N, Weirich B, Morancho B, Leote AC, D'Artista L, Gallage S, Seehawer M, Carroll T, Dharmalingam G, Wee KB, Mellone M, Pombo J, Heide D, Guccione E, Arribas J, Barbosa-Morais NL, Heikenwalder M, Thomas GJ, Zender L, Gil J. Georgilis A, et al. Cancer Cell. 2018 Jul 9;34(1):85-102.e9. doi: 10.1016/j.ccell.2018.06.007. Cancer Cell. 2018. PMID: 29990503 Free PMC article.
Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence.
Morancho B, Martínez-Barriocanal Á, Villanueva J, Arribas J. Morancho B, et al. Breast Cancer Res. 2015 Aug 12;17(1):106. doi: 10.1186/s13058-015-0619-7. Breast Cancer Res. 2015. PMID: 26260680 Free PMC article.
Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17.
Esselens CW, Malapeira J, Colomé N, Moss M, Canals F, Arribas J. Esselens CW, et al. Biol Chem. 2008 Aug;389(8):1075-84. doi: 10.1515/bc.2008.121. Biol Chem. 2008. PMID: 18979631
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis.
Bech-Serra JJ, Santiago-Josefat B, Esselens C, Saftig P, Baselga J, Arribas J, Canals F. Bech-Serra JJ, et al. Mol Cell Biol. 2006 Jul;26(13):5086-95. doi: 10.1128/MCB.02380-05. Mol Cell Biol. 2006. PMID: 16782893 Free PMC article.
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