Arunagiri A - Search Results

1

Proinsulin misfolding is an early event in the progression to type 2 diabetes.

Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Arunagiri A, et al. Elife. 2019 Jun 11;8:e44532. doi: 10.7554/eLife.44532. Elife. 2019. PMID: 31184302 Free PMC article.

2

Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.

Cunningham CN, He K, Arunagiri A, Paton AW, Paton JC, Arvan P, Tsai B. Cunningham CN, et al. Among authors: arunagiri a. Diabetes. 2017 Mar;66(3):741-753. doi: 10.2337/db16-1338. Epub 2016 Dec 27. Diabetes. 2017. PMID: 28028074 Free PMC article.

3

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.

Arunagiri A, Haataja L, Cunningham CN, Shrestha N, Tsai B, Qi L, Liu M, Arvan P. Arunagiri A, et al. Ann N Y Acad Sci. 2018 Apr;1418(1):5-19. doi: 10.1111/nyas.13531. Epub 2018 Jan 28. Ann N Y Acad Sci. 2018. PMID: 29377149 Free PMC article. Review.

4

Biosynthesis, structure, and folding of the insulin precursor protein.

Liu M, Weiss MA, Arunagiri A, Yong J, Rege N, Sun J, Haataja L, Kaufman RJ, Arvan P. Liu M, et al. Among authors: arunagiri a. Diabetes Obes Metab. 2018 Sep;20 Suppl 2(Suppl 2):28-50. doi: 10.1111/dom.13378. Diabetes Obes Metab. 2018. PMID: 30230185 Free PMC article. Review.

5

Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.

Cunningham CN, Williams JM, Knupp J, Arunagiri A, Arvan P, Tsai B. Cunningham CN, et al. Among authors: arunagiri a. Mol Cell. 2019 Aug 8;75(3):442-456.e4. doi: 10.1016/j.molcel.2019.05.011. Epub 2019 Jun 5. Mol Cell. 2019. PMID: 31176671 Free PMC article.

6

Normal and defective pathways in biogenesis and maintenance of the insulin storage pool.

Liu M, Huang Y, Xu X, Li X, Alam M, Arunagiri A, Haataja L, Ding L, Wang S, Itkin-Ansari P, Kaufman RJ, Tsai B, Qi L, Arvan P. Liu M, et al. Among authors: arunagiri a. J Clin Invest. 2021 Jan 19;131(2):e142240. doi: 10.1172/JCI142240. J Clin Invest. 2021. PMID: 33463547 Free PMC article. Review.

7

Distinct states of proinsulin misfolding in MIDY.

Haataja L, Arunagiri A, Hassan A, Regan K, Tsai B, Dhayalan B, Weiss MA, Liu M, Arvan P. Haataja L, et al. Among authors: arunagiri a. Cell Mol Life Sci. 2021 Aug;78(16):6017-6031. doi: 10.1007/s00018-021-03871-1. Epub 2021 Jul 10. Cell Mol Life Sci. 2021. PMID: 34245311 Free PMC article.

8

Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes.

Alam M, Arunagiri A, Haataja L, Torres M, Larkin D, Kappler J, Jin N, Arvan P. Alam M, et al. Among authors: arunagiri a. Diabetes. 2021 Nov;70(11):2580-2594. doi: 10.2337/db21-0422. Epub 2021 Aug 30. Diabetes. 2021. PMID: 34462258 Free PMC article.

9

PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones.

Chen YJ, Knupp J, Arunagiri A, Haataja L, Arvan P, Tsai B. Chen YJ, et al. Among authors: arunagiri a. Nat Commun. 2021 Oct 13;12(1):5991. doi: 10.1038/s41467-021-26225-8. Nat Commun. 2021. PMID: 34645803 Free PMC article.

10

The ER transmembrane protein PGRMC1 recruits misfolded proteins for reticulophagic clearance.

Knupp J, Chen YJ, Arunagiri A, Haataja L, Arvan P, Tsai B. Knupp J, et al. Among authors: arunagiri a. Autophagy. 2022 Jan;18(1):228-230. doi: 10.1080/15548627.2021.1997062. Epub 2021 Nov 15. Autophagy. 2022. PMID: 34779709 Free PMC article.

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