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Biological properties of D- and L-1-deoxyazasugars.
Kato A, Kato N, Kano E, Adachi I, Ikeda K, Yu L, Okamoto T, Banba Y, Ouchi H, Takahata H, Asano N. Kato A, et al. J Med Chem. 2005 Mar 24;48(6):2036-44. doi: 10.1021/jm0495881. J Med Chem. 2005. PMID: 15771446
Changes in urinary enzyme activity and histochemical findings in experimental tubular injury induced by gold sodium thiomalate.
Ogura T, Takaoka M, Yamauchi T, Oishi T, Mimura Y, Hashimoto M, Asano N, Yamamura M, Otsuka F, Makino H, Ota Z, Takahashi K. Ogura T, et al. J Med. 1996;27(1-2):41-55. J Med. 1996. PMID: 8863177
To elucidate the renal injury induced by gold treatment, we administered various doses of gold sodium thiomalate (GST) to Wistar rats and investigated alterations in the urinary enzyme activity, gamma-glutamyl transpeptidase (gamma GTP) and N-acetyl-beta-glucosaminidase (N …
To elucidate the renal injury induced by gold treatment, we administered various doses of gold sodium thiomalate (GST) to Wistar rats and in …
In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives.
Asano N, Ishii S, Kizu H, Ikeda K, Yasuda K, Kato A, Martin OR, Fan JQ. Asano N, et al. Eur J Biochem. 2000 Jul;267(13):4179-86. doi: 10.1046/j.1432-1327.2000.01457.x. Eur J Biochem. 2000. PMID: 10866822
., Asano, N. and Suzuki, Y. (1999) Nat. Med. 5, 112-115]. 1-Deoxygalactonojirimycin served as a specific chaperone for those mutant enzymes that failed to maintain their proper conformation to avoid excessive degradation. ...N-Alkylation, deoxygenation at C-2 …
., Asano, N. and Suzuki, Y. (1999) Nat. Med. 5, 112-115]. 1-Deoxygalactonojirimycin served as a specific chaperone for those m …
Specific alpha-galactosidase inhibitors, N-methylcalystegines--structure/activity relationships of calystegines from Lycium chinense.
Asano N, Kato A, Miyauchi M, Kizu H, Tomimori T, Matsui K, Nash RJ, Molyneux RJ. Asano N, et al. Eur J Biochem. 1997 Sep 1;248(2):296-303. doi: 10.1111/j.1432-1033.1997.00296.x. Eur J Biochem. 1997. PMID: 9346281
They were established as N-methylcalystegines B2 and C1, and their N-methyl groups were found to be axially oriented from NOE experiments. 1Beta-amino-3beta,4beta,5alpha-trihydroxycyclohepta ne was also present in L. chinense and may be a biosynthetic precursor of t …
They were established as N-methylcalystegines B2 and C1, and their N-methyl groups were found to be axially oriented from NOE …
Preparation and biological activity of manno- and galacto-validamines, new 5a-carba-glycosylamines as alpha-glycosidase inhibitors.
Kameda Y, Kawashima K, Takeuchi M, Ikeda K, Asano N, Matsui K. Kameda Y, et al. Carbohydr Res. 1997 May 16;300(3):259-64. doi: 10.1016/s0008-6215(97)00052-9. Carbohydr Res. 1997. PMID: 9202410
The inhibitory effect of the epimers on the N-linked oligosaccharide-processing mannosidases involved in glycoprotein biosynthesis and lysosomal mannosidase from rat liver were also examined. ...
The inhibitory effect of the epimers on the N-linked oligosaccharide-processing mannosidases involved in glycoprotein biosynthesis an …
2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease.
Kato A, Yamashita Y, Nakagawa S, Koike Y, Adachi I, Hollinshead J, Nash RJ, Ikeda K, Asano N. Kato A, et al. Bioorg Med Chem. 2010 Jun 1;18(11):3790-4. doi: 10.1016/j.bmc.2010.04.048. Epub 2010 Apr 21. Bioorg Med Chem. 2010. PMID: 20457528
The structures of new iminosugars were elucidated by spectroscopic methods as 2,5-dideoxy-2,5-imino-d-altritol (DIA) (2), beta-1-C-butenyl-1-deoxygalactonojirimycin (8), 2,3-dideoxy-beta-1-C-ethyl-1-deoxygalactonojirimycin (9), and 6-O-beta-d-glucopyranosyl-2,3-dideoxy-beta-1-C-e …
The structures of new iminosugars were elucidated by spectroscopic methods as 2,5-dideoxy-2,5-imino-d-altritol (DIA) (2), beta-1-C-butenyl-1 …
Enzymic synthesis of alpha- and beta-D-glucosides of 1-deoxynojirimycin and their glycosidase inhibitory activities.
Asano N, Oseki K, Kaneko E, Matsui K. Asano N, et al. Carbohydr Res. 1994 May 20;258:255-66. doi: 10.1016/0008-6215(94)84091-1. Carbohydr Res. 1994. PMID: 8039179
The transglucosylation reaction using native rice alpha-glucosidase afforded 3-O-alpha-D-glucopyranosyl-N-(benzyloxycarbonyl)-1-deoxynojirimycin (4), 4-O-alpha-D-glucopyranosyl-N-(benzyloxycarbonyl)-1-deoxynojirimycin (5), and 2-O-alpha-D-glucopyranosyl-N-(be …
The transglucosylation reaction using native rice alpha-glucosidase afforded 3-O-alpha-D-glucopyranosyl-N-(benzyloxycarbonyl)-1-deoxy …
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