Ascher DB - Search Results

1

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.

Ramdzan YM, Trubetskov MM, Ormsby AR, Newcombe EA, Sui X, Tobin MJ, Bongiovanni MN, Gras SL, Dewson G, Miller JML, Finkbeiner S, Moily NS, Niclis J, Parish CL, Purcell AW, Baker MJ, Wilce JA, Waris S, Stojanovski D, Böcking T, Ang CS, Ascher DB, Reid GE, Hatters DM. Ramdzan YM, et al. Among authors: ascher db. Cell Rep. 2017 May 2;19(5):919-927. doi: 10.1016/j.celrep.2017.04.029. Cell Rep. 2017. PMID: 28467905 Free article.

2

Widespread remodeling of proteome solubility in response to different protein homeostasis stresses.

Sui X, Pires DEV, Ormsby AR, Cox D, Nie S, Vecchi G, Vendruscolo M, Ascher DB, Reid GE, Hatters DM. Sui X, et al. Among authors: ascher db. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2422-2431. doi: 10.1073/pnas.1912897117. Epub 2020 Jan 21. Proc Natl Acad Sci U S A. 2020. PMID: 31964829 Free PMC article.

3

Sequence grammar underlying the unfolding and phase separation of globular proteins.

Ruff KM, Choi YH, Cox D, Ormsby AR, Myung Y, Ascher DB, Radford SE, Pappu RV, Hatters DM. Ruff KM, et al. Among authors: ascher db. Mol Cell. 2022 Sep 1;82(17):3193-3208.e8. doi: 10.1016/j.molcel.2022.06.024. Epub 2022 Jul 18. Mol Cell. 2022. PMID: 35853451 Free PMC article.

4

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.

Ascher DB, Wielens J, Nero TL, Doughty L, Morton CJ, Parker MW. Ascher DB, et al. Sci Rep. 2014 Apr 23;4:4765. doi: 10.1038/srep04765. Sci Rep. 2014. PMID: 24755925 Free PMC article.

5

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites.

Sernee MF, Ralton JE, Nero TL, Sobala LF, Kloehn J, Vieira-Lara MA, Cobbold SA, Stanton L, Pires DEV, Hanssen E, Males A, Ward T, Bastidas LM, van der Peet PL, Parker MW, Ascher DB, Williams SJ, Davies GJ, McConville MJ. Sernee MF, et al. Among authors: ascher db. Cell Host Microbe. 2019 Sep 11;26(3):385-399.e9. doi: 10.1016/j.chom.2019.08.009. Cell Host Microbe. 2019. PMID: 31513773 Free article.

6

Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches.

Portelli S, Myung Y, Furnham N, Vedithi SC, Pires DEV, Ascher DB. Portelli S, et al. Among authors: ascher db. Sci Rep. 2020 Oct 22;10(1):18120. doi: 10.1038/s41598-020-74648-y. Sci Rep. 2020. PMID: 33093532 Free PMC article.

7

Understanding and predicting the functional consequences of missense mutations in BRCA1 and BRCA2.

Aljarf R, Shen M, Pires DEV, Ascher DB. Aljarf R, et al. Among authors: ascher db. Sci Rep. 2022 Jun 21;12(1):10458. doi: 10.1038/s41598-022-13508-3. Sci Rep. 2022. PMID: 35729312 Free PMC article.

8

Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis.

Portelli S, Phelan JE, Ascher DB, Clark TG, Furnham N. Portelli S, et al. Among authors: ascher db. Sci Rep. 2018 Oct 18;8(1):15356. doi: 10.1038/s41598-018-33370-6. Sci Rep. 2018. PMID: 30337649 Free PMC article.

9

mCSM-membrane: predicting the effects of mutations on transmembrane proteins.

Pires DEV, Rodrigues CHM, Ascher DB. Pires DEV, et al. Among authors: ascher db. Nucleic Acids Res. 2020 Jul 2;48(W1):W147-W153. doi: 10.1093/nar/gkaa416. Nucleic Acids Res. 2020. PMID: 32469063 Free PMC article.

10

Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health.

Jubb HC, Pandurangan AP, Turner MA, Ochoa-Montaño B, Blundell TL, Ascher DB. Jubb HC, et al. Among authors: ascher db. Prog Biophys Mol Biol. 2017 Sep;128:3-13. doi: 10.1016/j.pbiomolbio.2016.10.002. Epub 2016 Nov 29. Prog Biophys Mol Biol. 2017. PMID: 27913149 Free article. Review.

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