Ashcroft FM - Search Results

1

Overexpression of Fto leads to increased food intake and results in obesity.

Church C, Moir L, McMurray F, Girard C, Banks GT, Teboul L, Wells S, Brüning JC, Nolan PM, Ashcroft FM, Cox RD. Church C, et al. Among authors: ashcroft fm. Nat Genet. 2010 Dec;42(12):1086-92. doi: 10.1038/ng.713. Epub 2010 Nov 14. Nat Genet. 2010. PMID: 21076408 Free PMC article.

2

A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.

Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldsworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD. Toye AA, et al. Among authors: ashcroft fm. Diabetologia. 2005 Apr;48(4):675-86. doi: 10.1007/s00125-005-1680-z. Epub 2005 Feb 24. Diabetologia. 2005. PMID: 15729571 Free article.

3

Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions.

Tammaro P, Girard C, Molnes J, Njølstad PR, Ashcroft FM. Tammaro P, et al. Among authors: ashcroft fm. EMBO J. 2005 Jul 6;24(13):2318-30. doi: 10.1038/sj.emboj.7600715. Epub 2005 Jun 16. EMBO J. 2005. PMID: 15962003 Free PMC article.

4

Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.

Proks P, Girard C, Ashcroft FM. Proks P, et al. Among authors: ashcroft fm. Hum Mol Genet. 2005 Sep 15;14(18):2717-26. doi: 10.1093/hmg/ddi305. Epub 2005 Aug 8. Hum Mol Genet. 2005. PMID: 16087682

5

Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion.

Freeman H, Shimomura K, Horner E, Cox RD, Ashcroft FM. Freeman H, et al. Among authors: ashcroft fm. Cell Metab. 2006 Jan;3(1):35-45. doi: 10.1016/j.cmet.2005.10.008. Cell Metab. 2006. PMID: 16399503 Free article.

6

A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.

Proks P, Arnold AL, Bruining J, Girard C, Flanagan SE, Larkin B, Colclough K, Hattersley AT, Ashcroft FM, Ellard S. Proks P, et al. Among authors: ashcroft fm. Hum Mol Genet. 2006 Jun 1;15(11):1793-800. doi: 10.1093/hmg/ddl101. Epub 2006 Apr 13. Hum Mol Genet. 2006. PMID: 16613899

7

Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.

Shimomura K, Girard CA, Proks P, Nazim J, Lippiat JD, Cerutti F, Lorini R, Ellard S, Hattersley AT, Barbetti F, Ashcroft FM. Shimomura K, et al. Among authors: ashcroft fm. Diabetes. 2006 Jun;55(6):1705-12. doi: 10.2337/db05-1640. Diabetes. 2006. PMID: 16731833

8

Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy.

Proks P, Girard C, Baevre H, Njølstad PR, Ashcroft FM. Proks P, et al. Among authors: ashcroft fm. Diabetes. 2006 Jun;55(6):1731-7. doi: 10.2337/db05-1420. Diabetes. 2006. PMID: 16731836

9

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC. Plum L, et al. Among authors: ashcroft fm. J Clin Invest. 2006 Jul;116(7):1886-901. doi: 10.1172/JCI27123. Epub 2006 Jun 22. J Clin Invest. 2006. PMID: 16794735 Free PMC article.

10

Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice.

Freeman HC, Hugill A, Dear NT, Ashcroft FM, Cox RD. Freeman HC, et al. Among authors: ashcroft fm. Diabetes. 2006 Jul;55(7):2153-6. doi: 10.2337/db06-0358. Diabetes. 2006. PMID: 16804088

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