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Apoptosis control by death and decoy receptors.

Ashkenazi A, Dixit VM. Ashkenazi A, et al. Curr Opin Cell Biol. 1999 Apr;11(2):255-60. doi: 10.1016/s0955-0674(99)80034-9. Curr Opin Cell Biol. 1999. PMID: 10209153 Review.

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Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis.

Roth W, Isenmann S, Nakamura M, Platten M, Wick W, Kleihues P, Bähr M, Ohgaki H, Ashkenazi A, Weller M. Roth W, et al. Among authors: ashkenazi a. Cancer Res. 2001 Mar 15;61(6):2759-65. Cancer Res. 2001. PMID: 11289159

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Designer proteins to trigger cell death.

Fairbrother WJ, Ashkenazi A. Fairbrother WJ, et al. Among authors: ashkenazi a. Cell. 2014 Jun 19;157(7):1506-8. doi: 10.1016/j.cell.2014.06.010. Cell. 2014. PMID: 24949963

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From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.

Ashkenazi A, Fairbrother WJ, Leverson JD, Souers AJ. Ashkenazi A, et al. Nat Rev Drug Discov. 2017 Apr;16(4):273-284. doi: 10.1038/nrd.2016.253. Epub 2017 Feb 17. Nat Rev Drug Discov. 2017. PMID: 28209992 Review.

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Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis.

Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A. Lu M, et al. Among authors: ashkenazi a. Science. 2014 Jul 4;345(6192):98-101. doi: 10.1126/science.1254312. Science. 2014. PMID: 24994655 Free PMC article.

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Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.

Chaudhuri A, Xie MH, Yang B, Mahapatra K, Liu J, Marsters S, Bodepudi S, Ashkenazi A. Chaudhuri A, et al. Among authors: ashkenazi a. J Biol Chem. 2011 Sep 16;286(37):32762-74. doi: 10.1074/jbc.M111.239384. Epub 2011 Jul 22. J Biol Chem. 2011. PMID: 21784853 Free PMC article.

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Cooperation of the agonistic DR5 antibody apomab with chemotherapy to inhibit orthotopic lung tumor growth and improve survival.

Jin H, Yang R, Ross J, Fong S, Carano R, Totpal K, Lawrence D, Zheng Z, Koeppen H, Stern H, Schwall R, Ashkenazi A. Jin H, et al. Among authors: ashkenazi a. Clin Cancer Res. 2008 Dec 1;14(23):7733-40. doi: 10.1158/1078-0432.CCR-08-0670. Clin Cancer Res. 2008. PMID: 19047100

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Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake.

Shang Y, Mao Y, Batson J, Scales SJ, Phillips G, Lackner MR, Totpal K, Williams S, Yang J, Tang Z, Modrusan Z, Tan C, Liang WC, Tsai SP, Vanderbilt A, Kozuka K, Hoeflich K, Tien J, Ross S, Li C, Lee SH, Song A, Wu Y, Stephan JP, Ashkenazi A, Zha J. Shang Y, et al. Among authors: ashkenazi a. Mol Cancer Ther. 2008 Sep;7(9):2599-608. doi: 10.1158/1535-7163.MCT-07-2401. Mol Cancer Ther. 2008. PMID: 18790743

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Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models.

French DM, Lin BC, Wang M, Adams C, Shek T, Hötzel K, Bolon B, Ferrando R, Blackmore C, Schroeder K, Rodriguez LA, Hristopoulos M, Venook R, Ashkenazi A, Desnoyers LR. French DM, et al. Among authors: ashkenazi a. PLoS One. 2012;7(5):e36713. doi: 10.1371/journal.pone.0036713. Epub 2012 May 15. PLoS One. 2012. PMID: 22615798 Free PMC article.

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The zebrafish as a model organism for the study of apoptosis.

Eimon PM, Ashkenazi A. Eimon PM, et al. Among authors: ashkenazi a. Apoptosis. 2010 Mar;15(3):331-49. doi: 10.1007/s10495-009-0432-9. Apoptosis. 2010. PMID: 20033783 Review.

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