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Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Ashkenazi A. Ashkenazi A. Nat Rev Cancer. 2002 Jun;2(6):420-30. doi: 10.1038/nrc821. Nat Rev Cancer. 2002. PMID: 12189384 Review. No abstract available.
Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis.
Roth W, Isenmann S, Nakamura M, Platten M, Wick W, Kleihues P, Bähr M, Ohgaki H, Ashkenazi A, Weller M. Roth W, et al. Cancer Res. 2001 Mar 15;61(6):2759-65. Cancer Res. 2001. PMID: 11289159
Decoy receptor 3 (DcR3) is a newly identified soluble protein that binds to CD95 ligand (CD95L) and inhibits its proapoptotic activity. ...
Decoy receptor 3 (DcR3) is a newly identified soluble protein that binds to CD95 ligand (CD95L) and inhibits its proapoptotic activit …
AXL inhibition sensitizes mesenchymal cancer cells to antimitotic drugs.
Wilson C, Ye X, Pham T, Lin E, Chan S, McNamara E, Neve RM, Belmont L, Koeppen H, Yauch RL, Ashkenazi A, Settleman J. Wilson C, et al. Cancer Res. 2014 Oct 15;74(20):5878-90. doi: 10.1158/0008-5472.CAN-14-1009. Epub 2014 Aug 14. Cancer Res. 2014. PMID: 25125659
Molecularly targeted drug therapies have revolutionized cancer treatment; however, resistance remains a major limitation to their overall efficacy. ...AXL is a receptor tyrosine kinase associated with EMT that has been implicated in drug resistance and has emerged a …
Molecularly targeted drug therapies have revolutionized cancer treatment; however, resistance remains a major limitation to their ove …
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.
Ashkenazi A, Fairbrother WJ, Leverson JD, Souers AJ. Ashkenazi A, et al. Nat Rev Drug Discov. 2017 Apr;16(4):273-284. doi: 10.1038/nrd.2016.253. Epub 2017 Feb 17. Nat Rev Drug Discov. 2017. PMID: 28209992 Review.
Members of the B cell lymphoma 2 (BCL-2) gene family have a central role in regulating programmed cell death by controlling pro-apoptotic and anti-apoptotic intracellular signals. In cancer, apoptosis evasion through dysregulation of specific BCL-2 family genes is a
Members of the B cell lymphoma 2 (BCL-2) gene family have a central role in regulating programmed cell death by controlling pro-apopt …
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis.
Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A. Lu M, et al. Science. 2014 Jul 4;345(6192):98-101. doi: 10.1126/science.1254312. Science. 2014. PMID: 24994655 Free PMC article.
Is SIRT2 required for necroptosis?
Newton K, Hildebrand JM, Shen Z, Rodriguez D, Alvarez-Diaz S, Petersen S, Shah S, Dugger DL, Huang C, Auwerx J, Vandenabeele P, Green DR, Ashkenazi A, Dixit VM, Kaiser WJ, Strasser A, Degterev A, Silke J. Newton K, et al. Nature. 2014 Feb 27;506(7489):E4-6. doi: 10.1038/nature13024. Nature. 2014. PMID: 24572428 Free PMC article.
Sirtuins can promote deacetylation of a wide range of substrates in diverse cellular compartments and regulate many cellular processes¹,². ...
Sirtuins can promote deacetylation of a wide range of substrates in diverse cellular compartments and regulate many cellular processe …
Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant.
Wilson NS, Duewell P, Yang B, Li Y, Marsters S, Koernig S, Latz E, Maraskovsky E, Morelli AB, Schnurr M, Ashkenazi A. Wilson NS, et al. J Immunol. 2014 Apr 1;192(7):3259-68. doi: 10.4049/jimmunol.1302011. Epub 2014 Mar 7. J Immunol. 2014. PMID: 24610009
The IL-18R pathway, but not IL-1R, was required for early innate and subsequent cellular immune responses to a model IMX vaccine. ...TNF-α provided a physiological priming signal for inflammasome-dependent IL-18 production by APCs, which correlated with reduced vacc …
The IL-18R pathway, but not IL-1R, was required for early innate and subsequent cellular immune responses to a model IMX vaccine. ... …
MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer.
Du X, Lin BC, Wang QR, Li H, Ingalla E, Tien J, Rooney I, Ashkenazi A, Penuel E, Qing J. Du X, et al. Clin Cancer Res. 2014 Dec 15;20(24):6324-35. doi: 10.1158/1078-0432.CCR-13-3336. Epub 2014 Oct 17. Clin Cancer Res. 2014. PMID: 25326231
The modulation of MMP-1 and MMP-10 by R3Mab in patients with bladder cancer was further evaluated in a phase I dose-escalation study. ...In a phase I dose-escalation trial, R3Mab administration resulted in an acute reduction of urinary MMP-1 and pro-MMP-10 levels in …
The modulation of MMP-1 and MMP-10 by R3Mab in patients with bladder cancer was further evaluated in a phase I dose-escalation study. …
FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth.
Du X, Wang QR, Chan E, Merchant M, Liu J, French D, Ashkenazi A, Qing J. Du X, et al. Cancer Res. 2012 Nov 15;72(22):5843-55. doi: 10.1158/0008-5472.CAN-12-1329. Epub 2012 Sep 26. Cancer Res. 2012. PMID: 23019225
Fibroblast growth factor receptor 3 (FGFR3) belongs to a family of receptor tyrosine kinases that control cell proliferation, differentiation, and survival. ...Together, these findings reveal a previously unrecognized role of FGFR3 in regulating lipid metabolism to …
Fibroblast growth factor receptor 3 (FGFR3) belongs to a family of receptor tyrosine kinases that control cell proliferation, differe …
Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.
Chaudhuri A, Xie MH, Yang B, Mahapatra K, Liu J, Marsters S, Bodepudi S, Ashkenazi A. Chaudhuri A, et al. J Biol Chem. 2011 Sep 16;286(37):32762-74. doi: 10.1074/jbc.M111.239384. Epub 2011 Jul 22. J Biol Chem. 2011. PMID: 21784853 Free PMC article.
Gab1 docks either directly or indirectly via Grb2 and controls only a subset of MET functions. Because MET and RON possess similar adaptor binding sites, it was anticipated that their adaptor interactions would be conserved. ...Hence, RON and MET differ in their adaptor in …
Gab1 docks either directly or indirectly via Grb2 and controls only a subset of MET functions. Because MET and RON possess similar ad …
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