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Prediction of drug tissue to plasma concentration ratios using a measured volume of distribution in combination with lipophilicity.
Jansson R, Bredberg U, Ashton M. Jansson R, et al. Among authors: ashton m. J Pharm Sci. 2008 Jun;97(6):2324-39. doi: 10.1002/jps.21130. J Pharm Sci. 2008. PMID: 17724666
No effect of chloroquine on theophylline pharmacokinetics in the rat.
Motti BA, Ashton M. Motti BA, et al. Among authors: ashton m. Biopharm Drug Dispos. 1998 Mar;19(2):97-100. doi: 10.1002/(sici)1099-081x(199803)19:2<97::aid-bdd75>;2-w. Biopharm Drug Dispos. 1998. PMID: 9533109
Artemisinin population pharmacokinetics in children and adults with uncomplicated falciparum malaria.
Sidhu JS, Ashton M, Huong NV, Hai TN, Karlsson MO, Sy ND, Jonsson EN, Cong LD. Sidhu JS, et al. Among authors: ashton m. Br J Clin Pharmacol. 1998 Apr;45(4):347-54. doi: 10.1046/j.1365-2125.1998.t01-1-00686.x. Br J Clin Pharmacol. 1998. PMID: 9578181 Free PMC article.
Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria.
Svensson US, Alin H, Karlsson MO, Bergqvist Y, Ashton M. Svensson US, et al. Among authors: ashton m. Eur J Clin Pharmacol. 2002 Aug;58(5):339-51. doi: 10.1007/s00228-002-0485-y. Epub 2002 Jul 13. Eur J Clin Pharmacol. 2002. PMID: 12185558 Clinical Trial.
Simultaneous enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma by liquid chromatography.
Jansson B, Simonsson US, Ashton M. Jansson B, et al. Among authors: ashton m. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791(1-2):179-91. doi: 10.1016/s1570-0232(03)00221-6. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 12798178
A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction.
Gordi T, Xie R, Huong NV, Huong DX, Karlsson MO, Ashton M. Gordi T, et al. Among authors: ashton m. Br J Clin Pharmacol. 2005 Feb;59(2):189-98. doi: 10.1111/j.1365-2125.2004.02321.x. Br J Clin Pharmacol. 2005. PMID: 15676041 Free PMC article. Clinical Trial.
Pitfalls in estimating piperaquine elimination.
Tarning J, Lindegårdh N, Annerberg A, Singtoroj T, Day NP, Ashton M, White NJ. Tarning J, et al. Among authors: ashton m. Antimicrob Agents Chemother. 2005 Dec;49(12):5127-8. doi: 10.1128/AAC.49.12.5127-5128.2005. Antimicrob Agents Chemother. 2005. PMID: 16304183 Free PMC article.
Development and validation of an automated solid phase extraction and liquid chromatographic method for the determination of piperaquine in urine.
Tarning J, Singtoroj T, Annerberg A, Ashton M, Bergqvist Y, White NJ, Day NP, Lindegardh N. Tarning J, et al. Among authors: ashton m. J Pharm Biomed Anal. 2006 Apr 11;41(1):213-8. doi: 10.1016/j.jpba.2005.10.027. Epub 2005 Nov 28. J Pharm Biomed Anal. 2006. PMID: 16311004
Pharmacokinetics of piperaquine after repeated oral administration of the antimalarial combination CV8 in 12 healthy male subjects.
Röshammar D, Hai TN, Friberg Hietala S, Van Huong N, Ashton M. Röshammar D, et al. Among authors: ashton m. Eur J Clin Pharmacol. 2006 May;62(5):335-41. doi: 10.1007/s00228-005-0084-9. Epub 2006 Mar 29. Eur J Clin Pharmacol. 2006. PMID: 16570188 Clinical Trial.
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.
Asimus S, Elsherbiny D, Hai TN, Jansson B, Huong NV, Petzold MG, Simonsson US, Ashton M. Asimus S, et al. Among authors: ashton m. Fundam Clin Pharmacol. 2007 Jun;21(3):307-16. doi: 10.1111/j.1472-8206.2007.00471.x. Fundam Clin Pharmacol. 2007. PMID: 17521300 Clinical Trial.
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