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Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides.
Dhanjal JK, Kumar V, Garg S, Subramani C, Agarwal S, Wang J, Zhang H, Kaul A, Kalra RS, Kaul SC, Vrati S, Sundar D, Wadhwa R. Dhanjal JK, et al. Int J Biol Macromol. 2021 Aug 1;184:297-312. doi: 10.1016/j.ijbiomac.2021.06.015. Epub 2021 Jun 9. Int J Biol Macromol. 2021. PMID: 34118289 Free PMC article.
COVID-19 caused by SARS-CoV-2 corona virus has become a global pandemic. In the absence of drugs and vaccine, and premises of time, efforts and cost required for their development, natural resources such as herbs are anticipated to provide some …
COVID-19 caused by SARS-CoV-2 corona virus has become a global pandemic. In the absence of drugs and vacc …
COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays.
Kalra RS, Kumar V, Dhanjal JK, Garg S, Li X, Kaul SC, Sundar D, Wadhwa R. Kalra RS, et al. J Biomol Struct Dyn. 2022 Oct;40(17):7885-7898. doi: 10.1080/07391102.2021.1902858. Epub 2021 Apr 2. J Biomol Struct Dyn. 2022. PMID: 33797339 Free PMC article.
SARS-CoV-2 outbreak in China in December 2019 and its spread as worldwide pandemic has been a major global health crisis. ...We investigated therapeutic efficacy of eight withanolides (derived from Ashwagandha) against the angiotensin-converting enzyme …
SARS-CoV-2 outbreak in China in December 2019 and its spread as worldwide pandemic has been a major global health crisi …
Anti-COVID-19 Potential of Withaferin-A and Caffeic Acid Phenethyl Ester.
Kumar V, Sari AN, Gupta D, Ishida Y, Terao K, Kaul SC, Vrati S, Sundar D, Wadhwa R. Kumar V, et al. Curr Top Med Chem. 2024;24(9):830-842. doi: 10.2174/0115680266280720231221100004. Curr Top Med Chem. 2024. PMID: 38279743
BACKGROUND: The recent COVID-19 (coronavirus disease 2019) pandemic triggered research on the development of new vaccines/drugs, repurposing of clinically approved drugs, and assessment of natural anti-COVID-19 compounds. ...Conversely, androgen antago …
BACKGROUND: The recent COVID-19 (coronavirus disease 2019) pandemic triggered research on the development of new vaccines/drug …
Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells.
Kumar V, Dhanjal JK, Bhargava P, Kaul A, Wang J, Zhang H, Kaul SC, Wadhwa R, Sundar D. Kumar V, et al. J Biomol Struct Dyn. 2022 Jan;40(1):1-13. doi: 10.1080/07391102.2020.1775704. Epub 2020 Jun 16. J Biomol Struct Dyn. 2022. PMID: 32469279 Free PMC article.
Coronavirus disease 2019 (COVID-19) initiated in December 2019 in Wuhan, China and became pandemic causing high fatality and disrupted normal life calling world almost to a halt. ...Furthermore, we investigated the effect of Wi-N on TMPRSS2 expression in MCF7 cells …
Coronavirus disease 2019 (COVID-19) initiated in December 2019 in Wuhan, China and became pandemic causing high fatality and d …
Withanone and caffeic acid phenethyl ester are predicted to interact with main protease (M(pro)) of SARS-CoV-2 and inhibit its activity.
Kumar V, Dhanjal JK, Kaul SC, Wadhwa R, Sundar D. Kumar V, et al. J Biomol Struct Dyn. 2021 Jul;39(11):3842-3854. doi: 10.1080/07391102.2020.1772108. Epub 2020 Jun 1. J Biomol Struct Dyn. 2021. PMID: 32431217 Free PMC article.
Here, we have examined the binding potential of Withaferin-A (Wi-A), Withanone (Wi-N) (active withanolides of Ashwagandha) and Caffeic Acid Phenethyl Ester (CAPE, bioactive ingredient of propolis) to a highly conserved protein, M(pro) of SARS-CoV-2. We …
Here, we have examined the binding potential of Withaferin-A (Wi-A), Withanone (Wi-N) (active withanolides of Ashwagandha) and Caffei …