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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NM, Jackson SP, Smith GC, Ashworth A. Farmer H, et al. Among authors: ashworth a. Nature. 2005 Apr 14;434(7035):917-21. doi: 10.1038/nature03445. Nature. 2005. PMID: 15829967
Poly(ADP-ribose) polymerase (PARP) is an enzyme involved in base excision repair, a key pathway in the repair of DNA single-strand breaks. ...
Poly(ADP-ribose) polymerase (PARP) is an enzyme involved in base excision repair, a key pathway in the repair of DNA single-strand br …
MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases.
Theodosiou A, Smith A, Gillieron C, Arkinstall S, Ashworth A. Theodosiou A, et al. Among authors: ashworth a. Oncogene. 1999 Nov 25;18(50):6981-8. doi: 10.1038/sj.onc.1203185. Oncogene. 1999. PMID: 10597297
Dual-specificity protein tyrosine phosphatases are a burgeoning family of enzymes, some of which, the MKPs, are implicated in the regulation of mitogen-activated protein (MAP) kinases. ...Here we describe the characterization of a novel member of the MKP family, MKP …
Dual-specificity protein tyrosine phosphatases are a burgeoning family of enzymes, some of which, the MKPs, are implicated in the reg …
Profiling familial breast cancer.
Lakhani SR, O'Hare MJ, Ashworth A. Lakhani SR, et al. Among authors: ashworth a. Nat Med. 2001 Apr;7(4):408-10. doi: 10.1038/86464. Nat Med. 2001. PMID: 11283660 No abstract available.
Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.
Tutt AN, van Oostrom CT, Ross GM, van Steeg H, Ashworth A. Tutt AN, et al. Among authors: ashworth a. EMBO Rep. 2002 Mar;3(3):255-60. doi: 10.1093/embo-reports/kvf037. Epub 2002 Feb 15. EMBO Rep. 2002. PMID: 11850397 Free PMC article.
To develop a mouse model that examines the effect of BRCA2 mutation and IR exposure on in vivo somatic mutation acquisition, we crossed mice with targeted disruption of Brca2 with a LacZ transgenic mutation reporter strain. ...IR (4 Gy) had a disproportionate …
To develop a mouse model that examines the effect of BRCA2 mutation and IR exposure on in vivo somatic mutation acquisition, we cross …
Microarray and histopathological analysis of tumours: the future and the past?
Lakhani SR, Ashworth A. Lakhani SR, et al. Among authors: ashworth a. Nat Rev Cancer. 2001 Nov;1(2):151-7. doi: 10.1038/35101087. Nat Rev Cancer. 2001. PMID: 11905806 Review.
Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations.
Warren M, Smith A, Partridge N, Masabanda J, Griffin D, Ashworth A. Warren M, et al. Among authors: ashworth a. Hum Mol Genet. 2002 Apr 1;11(7):841-51. doi: 10.1093/hmg/11.7.841. Hum Mol Genet. 2002. PMID: 11929857
Carriers of mutations in the BRCA2 gene have a high risk of developing breast and other cancers. The BRCA2 gene, which is located on human chromosome 13, encodes a very large protein of only poorly understood function. ...The chicken BRCA2 gene encodes a prot …
Carriers of mutations in the BRCA2 gene have a high risk of developing breast and other cancers. The BRCA2 gene, which is located on …
Biomedicine. D-Day for BRCA2.
Witt E, Ashworth A. Witt E, et al. Among authors: ashworth a. Science. 2002 Jul 26;297(5581):534. doi: 10.1126/science.1074482. Epub 2002 Jun 13. Science. 2002. PMID: 12065747 No abstract available.
The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.
Tutt A, Ashworth A. Tutt A, et al. Among authors: ashworth a. Trends Mol Med. 2002 Dec;8(12):571-6. doi: 10.1016/s1471-4914(02)02434-6. Trends Mol Med. 2002. PMID: 12470990 Review.
BRCA2 has a more specific role in DNA repair, regulating the activity of RAD51, which is required for homologous recombination. ...
BRCA2 has a more specific role in DNA repair, regulating the activity of RAD51, which is required for homologous recombination. ...
X-chromosome inactivation: X marks the spot for BRCA1.
Stone C, McCabe N, Ashworth A. Stone C, et al. Among authors: ashworth a. Curr Biol. 2003 Jan 21;13(2):R63-4. doi: 10.1016/s0960-9822(02)01430-6. Curr Biol. 2003. PMID: 12546807
Cell cycle and genetic background dependence of the effect of loss of BRCA2 on ionizing radiation sensitivity.
Tutt A, Connor F, Bertwistle D, Kerr P, Peacock J, Ross G, Ashworth A. Tutt A, et al. Among authors: ashworth a. Oncogene. 2003 May 15;22(19):2926-31. doi: 10.1038/sj.onc.1206522. Oncogene. 2003. PMID: 12771943
Carriers of mutations in the BRCA2 gene are at a highly elevated risk of breast and other cancers. The BRCA2 gene encodes a very large protein thought to play a role in DNA repair. ...Mouse embryo fibroblasts carrying this mutation have a proliferative …
Carriers of mutations in the BRCA2 gene are at a highly elevated risk of breast and other cancers. The BRCA2 gene encodes a ve …
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