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BRCA2 mutations in primary breast and ovarian cancers.
Lancaster JM, Wooster R, Mangion J, Phelan CM, Cochran C, Gumbs C, Seal S, Barfoot R, Collins N, Bignell G, Patel S, Hamoudi R, Larsson C, Wiseman RW, Berchuck A, Iglehart JD, Marks JR, Ashworth A, Stratton MR, Futreal PA. Lancaster JM, et al. Among authors: Ashworth A. Nat Genet. 1996 Jun;13(2):238-40. doi: 10.1038/ng0696-238. Nat Genet. 1996. PMID: 8640235
Genomics: Comparisons across cancers.
Ashworth A, Hudson TJ. Ashworth A, et al. Nature. 2013 Oct 17;502(7471):306-7. doi: 10.1038/502306a. Nature. 2013. PMID: 24132284 No abstract available.
Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial.
Tutt A, Tovey H, Cheang MCU, Kernaghan S, Kilburn L, Gazinska P, Owen J, Abraham J, Barrett S, Barrett-Lee P, Brown R, Chan S, Dowsett M, Flanagan JM, Fox L, Grigoriadis A, Gutin A, Harper-Wynne C, Hatton MQ, Hoadley KA, Parikh J, Parker P, Perou CM, Roylance R, Shah V, Shaw A, Smith IE, Timms KM, Wardley AM, Wilson G, Gillett C, Lanchbury JS, Ashworth A, Rahman N, Harries M, Ellis P, Pinder SE, Bliss JM. Tutt A, et al. Among authors: Ashworth A. Nat Med. 2018 May;24(5):628-637. doi: 10.1038/s41591-018-0009-7. Epub 2018 Apr 30. Nat Med. 2018. PMID: 29713086 Free PMC article. Clinical Trial.
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer.
Ruark E, Snape K, Humburg P, Loveday C, Bajrami I, Brough R, Rodrigues DN, Renwick A, Seal S, Ramsay E, Duarte Sdel V, Rivas MA, Warren-Perry M, Zachariou A, Campion-Flora A, Hanks S, Murray A, Ansari Pour N, Douglas J, Gregory L, Rimmer A, Walker NM, Yang TP, Adlard JW, Barwell J, Berg J, Brady AF, Brewer C, Brice G, Chapman C, Cook J, Davidson R, Donaldson A, Douglas F, Eccles D, Evans DG, Greenhalgh L, Henderson A, Izatt L, Kumar A, Lalloo F, Miedzybrodzka Z, Morrison PJ, Paterson J, Porteous M, Rogers MT, Shanley S, Walker L, Gore M, Houlston R, Brown MA, Caufield MJ, Deloukas P, McCarthy MI, Todd JA; Breast and Ovarian Cancer Susceptibility Collaboration; Wellcome Trust Case Control Consortium, Turnbull C, Reis-Filho JS, Ashworth A, Antoniou AC, Lord CJ, Donnelly P, Rahman N. Ruark E, et al. Among authors: Ashworth A. Nature. 2013 Jan 17;493(7432):406-10. doi: 10.1038/nature11725. Epub 2012 Dec 16. Nature. 2013. PMID: 23242139 Free PMC article.
Xist has properties of the X-chromosome inactivation centre.
Herzing LB, Romer JT, Horn JM, Ashworth A. Herzing LB, et al. Among authors: Ashworth A. Nature. 1997 Mar 20;386(6622):272-5. doi: 10.1038/386272a0. Nature. 1997. PMID: 9069284
BRCA1 and BRCA2 bind Stat5a and suppress its transcriptional activity.
Vidarsson H, Mikaelsdottir EK, Rafnar T, Bertwistle D, Ashworth A, Eyfjord JE, Valgeirsdottir S. Vidarsson H, et al. Among authors: Ashworth A. FEBS Lett. 2002 Dec 4;532(1-2):247-52. doi: 10.1016/s0014-5793(02)03684-0. FEBS Lett. 2002. PMID: 12459499
The BRC repeats are conserved in mammalian BRCA2 proteins.
Bignell G, Micklem G, Stratton MR, Ashworth A, Wooster R. Bignell G, et al. Among authors: Ashworth A. Hum Mol Genet. 1997 Jan;6(1):53-8. doi: 10.1093/hmg/6.1.53. Hum Mol Genet. 1997. PMID: 9002670
New complexities for BRCA1 and BRCA2.
Kerr P, Ashworth A. Kerr P, et al. Among authors: Ashworth A. Curr Biol. 2001 Aug 21;11(16):R668-76. doi: 10.1016/s0960-9822(01)00389-x. Curr Biol. 2001. PMID: 11525763 Review.
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