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7,065 results

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Page 1
A Comprehensive Review on L-Asparaginase and Its Applications.
Batool T, Makky EA, Jalal M, Yusoff MM. Batool T, et al. Appl Biochem Biotechnol. 2016 Mar;178(5):900-23. doi: 10.1007/s12010-015-1917-3. Epub 2015 Nov 7. Appl Biochem Biotechnol. 2016. PMID: 26547852 Review.
L-asparaginase (LA) catalyzes the degradation of asparagine, an essential amino acid for leukemic cells, into ammonia and aspartate. ...Pieces of information about the three-dimensional structure of L-asparaginase from Escherichia coli and Erwinia sp. have identifie …
L-asparaginase (LA) catalyzes the degradation of asparagine, an essential amino acid for leukemic cells, into ammonia and aspartate. …
Hypersensitivity reactions to asparaginase therapy in acute lymphoblastic leukemia: immunology and clinical consequences.
Burke MJ, Zalewska-Szewczyk B. Burke MJ, et al. Future Oncol. 2022 Mar;18(10):1285-1299. doi: 10.2217/fon-2021-1288. Epub 2022 Feb 2. Future Oncol. 2022. PMID: 35107320 Free article. Review.
Switching to alternative types of asparaginase is recommended for patients experiencing HSRs or silent inactivation; those with HSRs or silent inactivation on Escherichia coli-derived asparaginases should switch to another preparation. However, prior global shortage …
Switching to alternative types of asparaginase is recommended for patients experiencing HSRs or silent inactivation; those with HSRs …
PEG-asparaginase.
Fu CH, Sakamoto KM. Fu CH, et al. Expert Opin Pharmacother. 2007 Aug;8(12):1977-84. doi: 10.1517/14656566.8.12.1977. Expert Opin Pharmacother. 2007. PMID: 17696798 Review.
L-asparaginases have been established components in the treatment of acute leukemias for nearly 40 years. ...PEG-asparaginase, a form of Escherichia coli L-asparaginase covalently linked to polyethylene glycol, was rationally synthesized to decrease immunogen …
L-asparaginases have been established components in the treatment of acute leukemias for nearly 40 years. ...PEG-asparaginase, …
Recombinant Erwinia asparaginase (JZP458) in acute lymphoblastic leukemia: results from the phase 2/3 AALL1931 study.
Maese L, Loh ML, Choi MR, Lin T, Aoki E, Zanette M, Agarwal S, Iannone R, Silverman JA, Silverman LB, Raetz EA, Rau RE. Maese L, et al. Blood. 2023 Feb 16;141(7):704-712. doi: 10.1182/blood.2022016923. Blood. 2023. PMID: 36108304 Free PMC article. Clinical Trial.
AALL1931, a phase 2/3 study conducted in collaboration with the Children's Oncology Group, investigated the efficacy and safety of JZP458 (asparaginase erwinia chrysanthemi [recombinant]-rywn), a recombinant Erwinia asparaginase derived from a novel expression platf …
AALL1931, a phase 2/3 study conducted in collaboration with the Children's Oncology Group, investigated the efficacy and safety of JZP458 ( …
L-asparaginase-mediated Therapy in L-asparagine Auxotrophic Cancers: A Review.
Sindhu R, Manonmani HK. Sindhu R, et al. Anticancer Agents Med Chem. 2022;22(13):2393-2410. doi: 10.2174/1871520622666220106103336. Anticancer Agents Med Chem. 2022. PMID: 34994334 Review.
Microbial L-asparaginase is the most effective first-line therapy used in the treatment protocols of paediatric and adult leukemia. ...Although the off-target glutamine hydrolysis has been viewed as contributing to the drug-induced secondary responses in cells deficient wi …
Microbial L-asparaginase is the most effective first-line therapy used in the treatment protocols of paediatric and adult leukemia. . …
Microbial L-asparaginase: purification, characterization and applications.
Muneer F, Siddique MH, Azeem F, Rasul I, Muzammil S, Zubair M, Afzal M, Nadeem H. Muneer F, et al. Arch Microbiol. 2020 Jul;202(5):967-981. doi: 10.1007/s00203-020-01814-1. Epub 2020 Feb 12. Arch Microbiol. 2020. PMID: 32052094 Review.
L-asparaginases have an optimum pH range between 6 and 10 and an optimum temperature between 37 and 85 C. ...This review is an attempt to summarize most of the available sources, their phylogenetic relationships, purification methods, data regarding different physiochemica …
L-asparaginases have an optimum pH range between 6 and 10 and an optimum temperature between 37 and 85 C. ...This review is an attemp …
Circumventing the side effects of L-asparaginase.
Fonseca MHG, Fiúza TDS, Morais SB, Souza TACB, Trevizani R. Fonseca MHG, et al. Biomed Pharmacother. 2021 Jul;139:111616. doi: 10.1016/j.biopha.2021.111616. Epub 2021 Apr 28. Biomed Pharmacother. 2021. PMID: 33932739 Free article. Review.
L-asparaginase is an enzyme that catalyzes the degradation of asparagine and successfully used in the treatment of acute lymphoblastic leukemia. ...PEGylated versions have been incorporated into the treatment protocols to reduce immunogenicity and an alternative L-aspar …
L-asparaginase is an enzyme that catalyzes the degradation of asparagine and successfully used in the treatment of acute lymphoblasti …
L-Asparaginase delivery systems targeted to minimize its side-effects.
Talluri VP, Mutaliyeva B, Sharipova A, Ulaganathan V, Lanka SS, Aidarova S, Suigenbayeva A, Tleuova A. Talluri VP, et al. Adv Colloid Interface Sci. 2023 Jun;316:102915. doi: 10.1016/j.cis.2023.102915. Epub 2023 May 3. Adv Colloid Interface Sci. 2023. PMID: 37159987 Review.
L-asparaginase (L-ASP) is one of the key enzymes used in therapeutic applications, particularly to treat Acute Lymphocytic Leukemia (ALL). ...
L-asparaginase (L-ASP) is one of the key enzymes used in therapeutic applications, particularly to treat Acute Lymphocytic Leukemia ( …
Asparaginase revisited.
Capizzi RL. Capizzi RL. Leuk Lymphoma. 1993;10 Suppl:147-50. doi: 10.3109/10428199309149127. Leuk Lymphoma. 1993. PMID: 8481663 Review. No abstract available.
Can recombinant technology address asparaginase Erwinia chrysanthemi shortages?
Maese L, Rizzari C, Coleman R, Power A, van der Sluis I, Rau RE. Maese L, et al. Pediatr Blood Cancer. 2021 Oct;68(10):e29169. doi: 10.1002/pbc.29169. Epub 2021 Jun 8. Pediatr Blood Cancer. 2021. PMID: 34105243 Review.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Bacterial L-asparaginase has played an important role in ALL treatment for several decades; however, hypersensitivity reactions to Escherichia coli-derived asparaginases often preclude their use …
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Bacterial L-asparaginase has played an important role in ALL …
7,065 results