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Bisphosphonate use and atypical fractures of the femoral shaft.
Schilcher J, Michaëlsson K, Aspenberg P. Schilcher J, et al. Among authors: aspenberg p. N Engl J Med. 2011 May 5;364(18):1728-37. doi: 10.1056/NEJMoa1010650. N Engl J Med. 2011. PMID: 21542743
Surface immobilized bisphosphonate improves stainless-steel screw fixation in rats.
Tengvall P, Skoglund B, Askendal A, Aspenberg P. Tengvall P, et al. Among authors: aspenberg p. Biomaterials. 2004 May;25(11):2133-8. doi: 10.1016/j.biomaterials.2003.08.049. Biomaterials. 2004. PMID: 14741628
The results showed a 28% (p=0.0009) higher pullout force and 90% increased pullout energy for the bisphosphonate coated screws, and support the idea that surface immobilized bisphosphonates can be used to improve biomaterials fixation in bone....
The results showed a 28% (p=0.0009) higher pullout force and 90% increased pullout energy for the bisphosphonate coated screws, and s …
Stainless steel screws coated with bisphosphonates gave stronger fixation and more surrounding bone. Histomorphometry in rats.
Wermelin K, Suska F, Tengvall P, Thomsen P, Aspenberg P. Wermelin K, et al. Among authors: aspenberg p. Bone. 2008 Feb;42(2):365-71. doi: 10.1016/j.bone.2007.10.013. Epub 2007 Dec 11. Bone. 2008. PMID: 18055289
Glucocorticoids inhibit shaft fracture healing but not metaphyseal bone regeneration under stable mechanical conditions.
Sandberg OH, Aspenberg P. Sandberg OH, et al. Among authors: aspenberg p. Bone Joint Res. 2015 Oct;4(10):170-5. doi: 10.1302/2046-3758.410.2000414. Bone Joint Res. 2015. PMID: 26490971 Free PMC article.
Osteoporosis: the emperor has no clothes.
Järvinen TL, Michaëlsson K, Aspenberg P, Sievänen H. Järvinen TL, et al. Among authors: aspenberg p. J Intern Med. 2015 Jun;277(6):662-73. doi: 10.1111/joim.12366. J Intern Med. 2015. PMID: 25809279 Free PMC article. Review.
Manipulating the anabolic and catabolic response in bone graft remodeling: synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate.
Harding AK, Aspenberg P, Kataoka M, Bylski D, Tägil M. Harding AK, et al. Among authors: aspenberg p. J Orthop Res. 2008 Sep;26(9):1245-9. doi: 10.1002/jor.20625. J Orthop Res. 2008. PMID: 18404659

BMP-7 significantly (p = 0.007) increased new bone ingrowth distance into the graft from 2.0 mm (SD = 0.98 mm) in the controls to 3.1 mm (SD = 0.93 mm). ...A single injection of zoledronate significantly (p < 0.001) increased the trabecular volume/total volume to

BMP-7 significantly (p = 0.007) increased new bone ingrowth distance into the graft from 2.0 mm (SD = 0.98 mm) in the controls to 3.1 …
Efficacy of a sclerostin antibody compared to a low dose of PTH on metaphyseal bone healing.
Agholme F, Macias B, Hamang M, Lucchesi J, Adrian MD, Kuhstoss S, Harvey A, Sato M, Aspenberg P. Agholme F, et al. Among authors: aspenberg p. J Orthop Res. 2014 Mar;32(3):471-6. doi: 10.1002/jor.22525. Epub 2013 Nov 14. J Orthop Res. 2014. PMID: 24243768
After 4 weeks of treatment, PTH yielded a 48% increase in screw pull-out force compared to control (p = 0.03), while the antibody had no significant effect. ...
After 4 weeks of treatment, PTH yielded a 48% increase in screw pull-out force compared to control (p = 0.03), while the antibody had …
Simvastatin improves fracture healing in mice.
Skoglund B, Forslund C, Aspenberg P. Skoglund B, et al. Among authors: aspenberg p. J Bone Miner Res. 2002 Nov;17(11):2004-8. doi: 10.1359/jbmr.2002.17.11.2004. J Bone Miner Res. 2002. PMID: 12412808
At 14 days, the callus of the simvastatin-treated mice had a 53% larger transverse area than controls (p = 0.001), the force required to break the bone was 63% greater (p = 0.001), and the energy uptake was increased by 150% (p = 0.0008). ...
At 14 days, the callus of the simvastatin-treated mice had a 53% larger transverse area than controls (p = 0.001), the force required …
Low dose PTH improves metaphyseal bone healing more when muscles are paralyzed.
Sandberg O, Macias BR, Aspenberg P. Sandberg O, et al. Among authors: aspenberg p. Bone. 2014 Jun;63:15-9. doi: 10.1016/j.bone.2014.02.008. Epub 2014 Feb 26. Bone. 2014. PMID: 24582802
In relative terms, PTH had a stronger effect on pull-out force in unloaded bone than in loaded bone (p=0.03). The results suggest that PTH treatment for stimulation of bone healing does not require simultaneous mechanical stimulation....
In relative terms, PTH had a stronger effect on pull-out force in unloaded bone than in loaded bone (p=0.03). The results suggest tha …
Surface immobilized zoledronate improves screw fixation in rat bone: a new method for the coating of metal implants.
Andersson T, Agholme F, Aspenberg P, Tengvall P. Andersson T, et al. Among authors: aspenberg p. J Mater Sci Mater Med. 2010 Nov;21(11):3029-37. doi: 10.1007/s10856-010-4154-x. Epub 2010 Sep 21. J Mater Sci Mater Med. 2010. PMID: 20857321
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