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Antibody-based proteomics for discovery and exploration of proteins expressed in pancreatic islets.
Lindskog C, Asplund A, Engkvist M, Uhlen M, Korsgren O, Ponten F. Lindskog C, et al. Discov Med. 2010 Jun;9(49):565-78. Discov Med. 2010. PMID: 20587347
Of the five novel endocrine markers, tetraspanin-7 was identified as a membrane-bound protein with exclusive positivity in islet cells. Also beta-2-microglobulin and ubiquitin carboxyl-terminal hydrolase isozyme L1 were expressed in a majority of islet cells, wherea …
Of the five novel endocrine markers, tetraspanin-7 was identified as a membrane-bound protein with exclusive positivity in islet cell …
Clonality analysis of synchronous lesions of cervical carcinoma based on X chromosome inactivation polymorphism, human papillomavirus type 16 genome mutations, and loss of heterozygosity.
Hu X, Pang T, Asplund A, Pontén J, Nistér M. Hu X, et al. J Exp Med. 2002 Apr 1;195(7):845-54. doi: 10.1084/jem.20011564. J Exp Med. 2002. PMID: 11927629 Free PMC article.
To understand the causes, origin, and model of progression of cervical carcinoma, we assessed the clonality of a case with multiple synchronous lesions by analyzing X chromosome inactivation polymorphism, human papillomavirus type 16 (HPV16) sequence variation/mutations, a …
To understand the causes, origin, and model of progression of cervical carcinoma, we assessed the clonality of a case with multiple s …
Affinity proteomics for systematic protein profiling of chromosome 21 gene products in human tissues.
Agaton C, Galli J, Höidén Guthenberg I, Janzon L, Hansson M, Asplund A, Brundell E, Lindberg S, Ruthberg I, Wester K, Wurtz D, Höög C, Lundeberg J, Ståhl S, Pontén F, Uhlén M. Agaton C, et al. Mol Cell Proteomics. 2003 Jun;2(6):405-14. doi: 10.1074/mcp.M300022-MCP200. Epub 2003 Jun 9. Mol Cell Proteomics. 2003. PMID: 12796447
Using human tissue arrays, a systematic profiling of protein expression and subcellular localization was undertaken for the putative gene products. The results suggest that this affinity proteomics strategy can be used to produce a proteome atlas, describing distrib …
Using human tissue arrays, a systematic profiling of protein expression and subcellular localization was undertaken for the putative …
Zinc-based fixative improves preservation of genomic DNA and proteins in histoprocessing of human tissues.
Wester K, Asplund A, Bäckvall H, Micke P, Derveniece A, Hartmane I, Malmström PU, Pontén F. Wester K, et al. Lab Invest. 2003 Jun;83(6):889-99. doi: 10.1097/01.lab.0000074892.53211.a5. Lab Invest. 2003. PMID: 12808124
Despite excellent morphology for routine diagnostics, a major drawback of NBF fixation is its detrimental effect on DNA and RNA quality. ...In the present study, we evaluated a zinc-based fixative (ZBF) regarding its effects on tissue morphology, quality of genomic …
Despite excellent morphology for routine diagnostics, a major drawback of NBF fixation is its detrimental effect on DNA and RNA quali …
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Pontén F. Uhlén M, et al. Mol Cell Proteomics. 2005 Dec;4(12):1920-32. doi: 10.1074/mcp.M500279-MCP200. Epub 2005 Aug 27. Mol Cell Proteomics. 2005. PMID: 16127175
Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. ...Each image has been annotated by a certified pathologist to provide a knowledge …
Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic genera …
A high-throughput strategy for protein profiling in cell microarrays using automated image analysis.
Strömberg S, Björklund MG, Asplund C, Sköllermo A, Persson A, Wester K, Kampf C, Nilsson P, Andersson AC, Uhlen M, Kononen J, Ponten F, Asplund A. Strömberg S, et al. Proteomics. 2007 Jun;7(13):2142-50. doi: 10.1002/pmic.200700199. Proteomics. 2007. PMID: 17549799
Here we present a high-throughput strategy combining IHC on a recently developed cell microarray with a novel, automated image-analysis application (TMAx). ...In conclusion, automated analysis of immunohistochemically stained in vitro-cultured cells in a
Here we present a high-throughput strategy combining IHC on a recently developed cell microarray with a novel, automate …
Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma.
Asplund A, Gry Björklund M, Sundquist C, Strömberg S, Edlund K, Ostman A, Nilsson P, Pontén F, Lundeberg J. Asplund A, et al. Br J Dermatol. 2008 Mar;158(3):527-38. doi: 10.1111/j.1365-2133.2007.08418.x. Epub 2008 Jan 30. Br J Dermatol. 2008. PMID: 18241271
Extracted RNA was amplified and hybridized on to a cDNA microarray. Results Our results show that BCC cells express a transcript signature that is significantly different from that of normal keratinocytes, and over 350 genes with various functions were identified as …
Extracted RNA was amplified and hybridized on to a cDNA microarray. Results Our results show that BCC cells express a transcri …
Transcriptional profiling of melanocytes from patients with vitiligo vulgaris.
Strömberg S, Björklund MG, Asplund A, Rimini R, Lundeberg J, Nilsson P, Pontén F, Olsson MJ. Strömberg S, et al. Pigment Cell Melanoma Res. 2008 Apr;21(2):162-71. doi: 10.1111/j.1755-148X.2007.00429.x. Pigment Cell Melanoma Res. 2008. PMID: 18426409
Vitiligo is a complex, polygenic disorder characterized by patchy loss of skin pigmentation due to abnormal melanocyte function. ...In conclusion, our results show a significantly different transcription profile in melanocytes from vitiligo patients compared with co …
Vitiligo is a complex, polygenic disorder characterized by patchy loss of skin pigmentation due to abnormal melanocyte function. ...I …
A genecentric Human Protein Atlas for expression profiles based on antibodies.
Berglund L, Björling E, Oksvold P, Fagerberg L, Asplund A, Szigyarto CA, Persson A, Ottosson J, Wernérus H, Nilsson P, Lundberg E, Sivertsson A, Navani S, Wester K, Kampf C, Hober S, Pontén F, Uhlén M. Berglund L, et al. Mol Cell Proteomics. 2008 Oct;7(10):2019-27. doi: 10.1074/mcp.R800013-MCP200. Mol Cell Proteomics. 2008. PMID: 18669619 Review.
An attractive path forward in proteomics is to experimentally annotate the human protein complement of the genome in a genecentric manner. ...The exact antigen sequence for the internally generated antibodies has also been released together with a visualization of t …
An attractive path forward in proteomics is to experimentally annotate the human protein complement of the genome in a genecentric ma …
The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival.
Wang X, Asplund AC, Porwit A, Flygare J, Smith CI, Christensson B, Sander B. Wang X, et al. Br J Haematol. 2008 Oct;143(2):248-52. doi: 10.1111/j.1365-2141.2008.07329.x. Epub 2008 Aug 20. Br J Haematol. 2008. PMID: 18729857
Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results sugges …
Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 …
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