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Sun-induced nonsynonymous p53 mutations are extensively accumulated and tolerated in normal appearing human skin.
Ståhl PL, Stranneheim H, Asplund A, Berglund L, Pontén F, Lundeberg J. Ståhl PL, et al. Among authors: asplund a. J Invest Dermatol. 2011 Feb;131(2):504-8. doi: 10.1038/jid.2010.302. Epub 2010 Oct 14. J Invest Dermatol. 2011. PMID: 20944651
Deep sequencing of sun-exposed and shielded microdissected skin from mid-life individuals revealed that persistent p53 mutations had accumulated in 14% of all epidermal cells, with no apparent signs of a growth advantage of the affected cell compartments. Furthermore, 6% o …
Deep sequencing of sun-exposed and shielded microdissected skin from mid-life individuals revealed that persistent p53 mutations had accumul …
Mosaic pattern of maternal and paternal keratinocyte clones in normal human epidermis revealed by analysis of X-chromosome inactivation.
Asplund A, Guo Z, Hu X, Wassberg C, Pontén F. Asplund A, et al. J Invest Dermatol. 2001 Jul;117(1):128-31. doi: 10.1046/j.0022-202x.2001.01385.x. J Invest Dermatol. 2001. PMID: 11442759
As a result of growth, migration, and differentiation, the adult female becomes a mosaic of cells with either the paternal or the maternal X-chromosome inactivated. ...Through examination of adjacent samples and consecutive sections, we found normal human skin to be …
As a result of growth, migration, and differentiation, the adult female becomes a mosaic of cells with either the paternal or …
Mutation spectra of epidermal p53 clones adjacent to basal cell carcinoma and squamous cell carcinoma.
Bäckvall H, Strömberg S, Gustafsson A, Asplund A, Sivertsson A, Lundeberg J, Ponten F. Bäckvall H, et al. Among authors: asplund a. Exp Dermatol. 2004 Oct;13(10):643-50. doi: 10.1111/j.0906-6705.2004.00211.x. Exp Dermatol. 2004. PMID: 15447725
Such epidermal p53 clones are common in chronically sun-exposed skin and have been suggested to play a role in skin cancer development. ...Genetic analysis was performed using a multiplex/nested polymerase chain reaction followed by direct DNA sequencing of p53 exon …
Such epidermal p53 clones are common in chronically sun-exposed skin and have been suggested to play a role in skin cancer developmen …
Genetic tumor archeology: microdissection and genetic heterogeneity in squamous and basal cell carcinoma.
Bäckvall H, Asplund A, Gustafsson A, Sivertsson A, Lundeberg J, Ponten F. Bäckvall H, et al. Among authors: asplund a. Mutat Res. 2005 Apr 1;571(1-2):65-79. doi: 10.1016/j.mrfmmm.2004.10.011. Mutat Res. 2005. PMID: 15748639 Review.
A high frequency of epidermal p53 clones has been detected in chronically sun-exposed skin. The abundance of clones containing p53 mutated keratinocytes adjacent to basal cell (BCC) and squamous cell carcinoma (SCC) suggests a role in human skin carcinogenesis. Stud
A high frequency of epidermal p53 clones has been detected in chronically sun-exposed skin. The abundance of clones containing p53 mu
The role of p53 codon 72 and human papilloma virus status of cutaneous squamous cell carcinoma in the Swedish population.
Gustafsson AC, Ren ZP, Asplund A, Pontén F, Lundeberg J. Gustafsson AC, et al. Among authors: asplund a. Acta Derm Venereol. 2004;84(6):439-44. doi: 10.1080/00015550410021673. Acta Derm Venereol. 2004. PMID: 15844633
Data also indicate that anogenital HPV is more common in tumour samples, but HPV infection was not identified as a significant risk factor for developing SCC. The presence of anogenital HPV, but not EV HPV might be a risk factor for development of cutaneous SCC....
Data also indicate that anogenital HPV is more common in tumour samples, but HPV infection was not identified as a significant risk f …
PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer.
Asplund A, Gustafsson AC, Wikonkal NM, Sela A, Leffell DJ, Kidd K, Lundeberg J, Brash DE, Pontén F. Asplund A, et al. Br J Dermatol. 2005 May;152(5):868-73. doi: 10.1111/j.1365-2133.2005.06464.x. Br J Dermatol. 2005. PMID: 15888139 Clinical Trial.
Objectives Accordingly, the status of PTCH codon 1315 was analysed for a possible association with the development of nonmelanoma skin cancers (NMSCs) in a pilot study. ...RESULTS: The Pro/Pro genotype frequency ranged from 30% to 65% between populations, with a
Objectives Accordingly, the status of PTCH codon 1315 was analysed for a possible association with the development of nonmelanoma ski …
Genetic mosaicism in basal cell carcinoma.
Asplund A, Sivertsson A, Bäckvall H, Ahmadian A, Lundeberg J, Ponten F. Asplund A, et al. Exp Dermatol. 2005 Aug;14(8):593-600. doi: 10.1111/j.0906-6705.2005.00333.x. Exp Dermatol. 2005. PMID: 16026581
Human basal cell cancer (BCC) shows unique growth characteristics, including a virtual inability to metastasize, absence of a precursor stage and lack of tumour progression. The clonal nature of BCC has long been a subject for debate because of the tumour gro …
Human basal cell cancer (BCC) shows unique growth characteristics, including a virtual inability to metastasize, absence of a
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H. Barbe L, et al. Among authors: asplund a. Mol Cell Proteomics. 2008 Mar;7(3):499-508. doi: 10.1074/mcp.M700325-MCP200. Epub 2007 Nov 19. Mol Cell Proteomics. 2008. PMID: 18029348
Here we report on a pilot study of 466 proteins in three human cell lines aimed to allow large scale confocal microscopy analysis using protein-specific antibodies. ...The results suggest that this approach might be a valuable tool in conjunction with predictive mod …
Here we report on a pilot study of 466 proteins in three human cell lines aimed to allow large scale confocal microscopy analysis usi …
Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma.
Asplund A, Gry Björklund M, Sundquist C, Strömberg S, Edlund K, Ostman A, Nilsson P, Pontén F, Lundeberg J. Asplund A, et al. Br J Dermatol. 2008 Mar;158(3):527-38. doi: 10.1111/j.1365-2133.2007.08418.x. Epub 2008 Jan 30. Br J Dermatol. 2008. PMID: 18241271
Extracted RNA was amplified and hybridized on to a cDNA microarray. Results Our results show that BCC cells express a transcript signature that is significantly different from that of normal keratinocytes, and over 350 genes with various functions were identified as …
Extracted RNA was amplified and hybridized on to a cDNA microarray. Results Our results show that BCC cells express a transcri …
The correlation between cellular size and protein expression levels--normalization for global protein profiling.
Lundberg E, Gry M, Oksvold P, Kononen J, Andersson-Svahn H, Pontén F, Uhlén M, Asplund A. Lundberg E, et al. Among authors: asplund a. J Proteomics. 2008 Oct 7;71(4):448-60. doi: 10.1016/j.jprot.2008.06.014. Epub 2008 Jul 5. J Proteomics. 2008. PMID: 18656560
The analysis suggests that most proteins are expressed in a cell size dependent manner, and that normalization is required for comparative protein quantification in order to correct for the inherent bias of cell size and systematic ambiguities associated with immunohistoch …
The analysis suggests that most proteins are expressed in a cell size dependent manner, and that normalization is required for compar …
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