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High-risk HPV infection and CIN grade correlates to the expression of c-myc, CD4+, FHIT, E-cadherin, Ki-67, and p16INK4a.
Samir R, Asplund A, Tot T, Pekar G, Hellberg D. Samir R, et al. J Low Genit Tract Dis. 2011 Oct;15(4):280-6. doi: 10.1097/LGT.0b013e318215170c. J Low Genit Tract Dis. 2011. PMID: 21558960
OBJECTIVE: : This study aimed to investigate correlations between a panel of biomarkers/tumor markers and high-risk (HR) human papillomavirus (HPV)-positive versus HR-HPV-negative cervical lesions. MATERIALS AND METHODS: : The study included 188 women who consecutively att …
OBJECTIVE: : This study aimed to investigate correlations between a panel of biomarkers/tumor markers and high-risk (HR) human papill …
Tissue tumor marker expression in smokers, including serum cotinine concentrations, in women with cervical intraepithelial neoplasia or normal squamous cervical epithelium.
Samir R, Asplund A, Tot T, Pekar G, Hellberg D. Samir R, et al. Am J Obstet Gynecol. 2010 Jun;202(6):579.e1-7. doi: 10.1016/j.ajog.2009.11.034. Epub 2010 Jan 13. Am J Obstet Gynecol. 2010. PMID: 20060094
This provides biologic evidence of smoking being a true cofactor in cervical neoplasia....
This provides biologic evidence of smoking being a true cofactor in cervical neoplasia....
Molecular profiling using tissue microarrays as a tool to identify predictive biomarkers in laryngeal cancer treated with radiotherapy.
Holgersson G, Ekman S, Reizenstein J, Bergqvist M, Pontén F, Uhlén M, Magnusson K, Jonnalagadda P, Asplund A, Strömberg S, Linder A, Blomquist E, Liljeholm M, Lödén B, Hellström K, Bergström S. Holgersson G, et al. Cancer Genomics Proteomics. 2010 Jan-Feb;7(1):1-7. Cancer Genomics Proteomics. 2010. PMID: 20181625
RESULTS: A total of 39 patients were included in the present study. Nuclear MSH2 staining was statistically significantly correlated to Ki-67 expression (p=0.022). ...However, with larger patient cohorts, we believe that protein profiling using TMAs and immunohistochemistr …
RESULTS: A total of 39 patients were included in the present study. Nuclear MSH2 staining was statistically significantly correlated …
Oral contraceptive and progestin-only use correlates to tissue tumor marker expression in women with cervical intraepithelial neoplasia.
Samir R, Asplund A, Tot T, Pekar G, Hellberg D. Samir R, et al. Contraception. 2012 Mar;85(3):288-93. doi: 10.1016/j.contraception.2011.09.001. Epub 2011 Oct 11. Contraception. 2012. PMID: 22067748
When users of progestogen-only contraceptives were analyzed, there was a lower expression of cytokeratin 10 and interleukin 10. When only MID users were analyzed, a high expression of p53 was found. Expression of Cox-2, p53 and retinoblastoma protein differed betwee …
When users of progestogen-only contraceptives were analyzed, there was a lower expression of cytokeratin 10 and interleukin 10. When …
Correlation between LRIG1 and LRIG2 expressions and expression of 11 tumor markers, with special reference to tumor suppressors, in CIN and normal cervical epithelium.
Lindström AK, Asplund A, Hellberg D. Lindström AK, et al. Gynecol Oncol. 2011 Aug;122(2):372-6. doi: 10.1016/j.ygyno.2011.04.049. Epub 2011 May 31. Gynecol Oncol. 2011. PMID: 21632100
Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma.
Strömberg S, Agnarsdóttir M, Magnusson K, Rexhepaj E, Bolander A, Lundberg E, Asplund A, Ryan D, Rafferty M, Gallagher WM, Uhlen M, Bergqvist M, Ponten F. Strömberg S, et al. J Proteome Res. 2009 Apr;8(4):1639-46. doi: 10.1021/pr800745e. J Proteome Res. 2009. PMID: 19714869
Syntaxin-7 (STX7) was identified as a novel protein, not previously characterized in cells of melanocytic lineage, displaying a cell type-specific protein expression pattern. ...In conclusion, we present protein profiling data for a novel protein showing high …
Syntaxin-7 (STX7) was identified as a novel protein, not previously characterized in cells of melanocytic lineage, displaying a
Clonality analysis of synchronous lesions of cervical carcinoma based on X chromosome inactivation polymorphism, human papillomavirus type 16 genome mutations, and loss of heterozygosity.
Hu X, Pang T, Asplund A, Pontén J, Nistér M. Hu X, et al. J Exp Med. 2002 Apr 1;195(7):845-54. doi: 10.1084/jem.20011564. J Exp Med. 2002. PMID: 11927629 Free PMC article.
To understand the causes, origin, and model of progression of cervical carcinoma, we assessed the clonality of a case with multiple synchronous lesions by analyzing X chromosome inactivation polymorphism, human papillomavirus type 16 (HPV16) sequence variation/mutations, a …
To understand the causes, origin, and model of progression of cervical carcinoma, we assessed the clonality of a case with multiple s …
Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma.
Asplund A, Gry Björklund M, Sundquist C, Strömberg S, Edlund K, Ostman A, Nilsson P, Pontén F, Lundeberg J. Asplund A, et al. Br J Dermatol. 2008 Mar;158(3):527-38. doi: 10.1111/j.1365-2133.2007.08418.x. Epub 2008 Jan 30. Br J Dermatol. 2008. PMID: 18241271
Extracted RNA was amplified and hybridized on to a cDNA microarray. Results Our results show that BCC cells express a transcript signature that is significantly different from that of normal keratinocytes, and over 350 genes with various functions were identified as …
Extracted RNA was amplified and hybridized on to a cDNA microarray. Results Our results show that BCC cells express a transcri …
The correlation between cellular size and protein expression levels--normalization for global protein profiling.
Lundberg E, Gry M, Oksvold P, Kononen J, Andersson-Svahn H, Pontén F, Uhlén M, Asplund A. Lundberg E, et al. J Proteomics. 2008 Oct 7;71(4):448-60. doi: 10.1016/j.jprot.2008.06.014. Epub 2008 Jul 5. J Proteomics. 2008. PMID: 18656560
The analysis suggests that most proteins are expressed in a cell size dependent manner, and that normalization is required for comparative protein quantification in order to correct for the inherent bias of cell size and systematic ambiguities associated with immunohistoch …
The analysis suggests that most proteins are expressed in a cell size dependent manner, and that normalization is required for compar …
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