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Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA. Holt MC, et al. Among authors: assar z. Biochemistry. 2018 Nov 27;57(47):6604-6614. doi: 10.1021/acs.biochem.8b00914. Epub 2018 Nov 12. Biochemistry. 2018. PMID: 30365304 Free PMC article.
Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Cohen F, Aggen JB, Andrews LD, Assar Z, Boggs J, Choi T, Dozzo P, Easterday AN, Haglund CM, Hildebrandt DJ, Holt MC, Joly K, Jubb A, Kamal Z, Kane TR, Konradi AW, Krause KM, Linsell MS, Machajewski TD, Miroshnikova O, Moser HE, Nieto V, Phan T, Plato C, Serio AW, Seroogy J, Shakhmin A, Stein AJ, Sun AD, Sviridov S, Wang Z, Wlasichuk K, Yang W, Zhou X, Zhu H, Cirz RT. Cohen F, et al. Among authors: assar z. ChemMedChem. 2019 Aug 20;14(16):1560-1572. doi: 10.1002/cmdc.201900287. Epub 2019 Aug 5. ChemMedChem. 2019. PMID: 31283109
Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches.
Ghanbarpour A, Pinger C, Esmatpour Salmani R, Assar Z, Santos EM, Nosrati M, Pawlowski K, Spence D, Vasileiou C, Jin X, Borhan B, Geiger JH. Ghanbarpour A, et al. Among authors: assar z. J Am Chem Soc. 2019 Oct 30;141(43):17125-17132. doi: 10.1021/jacs.9b04664. Epub 2019 Oct 16. J Am Chem Soc. 2019. PMID: 31557439 Free PMC article.
ERO1-PDI Redox Signaling in Health and Disease.
Jha V, Kumari T, Manickam V, Assar Z, Olson KL, Min JK, Cho J. Jha V, et al. Among authors: assar z. Antioxid Redox Signal. 2021 Nov 1;35(13):1093-1115. doi: 10.1089/ars.2021.0018. Epub 2021 Jul 13. Antioxid Redox Signal. 2021. PMID: 34074138 Free PMC article. Review.