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Assays for investigating deSUMOylation enzymes.
Madu IG, Chen Y. Madu IG, et al. Curr Protoc Mol Biol. 2012 Jul;Chapter 10:Unit10.30. doi: 10.1002/0471142727.mb1030s99. Curr Protoc Mol Biol. 2012. PMID: 22870856 Free PMC article.
At least six deSUMOylation enzymes, all of which are encoded by essential genes, have been identified in mammals. SENP1 has been shown to play an important role in the development of prostate cancer and in angiogenesis. This unit describes and discusses methods for …
At least six deSUMOylation enzymes, all of which are encoded by essential genes, have been identified in mammals. SENP1 has be …
SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop.
Cui CP, Wong CC, Kai AK, Ho DW, Lau EY, Tsui YM, Chan LK, Cheung TT, Chok KS, Chan ACY, Lo RC, Lee JM, Lee TK, Ng IOL. Cui CP, et al. Gut. 2017 Dec;66(12):2149-2159. doi: 10.1136/gutjnl-2016-313264. Epub 2017 Mar 3. Gut. 2017. PMID: 28258134 Free PMC article.
OBJECTIVE: We investigated the effect and mechanism of hypoxic microenvironment and hypoxia-inducible factors (HIFs) on hepatocellular carcinoma (HCC) cancer stemness. ...Immunoprecipitation was used to examine the binding of proteins and chromatin immunoprecipitation a
OBJECTIVE: We investigated the effect and mechanism of hypoxic microenvironment and hypoxia-inducible factors (HIFs) on hepatocellula …
The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression.
Rodríguez-Castañeda F, Lemma RB, Cuervo I, Bengtsen M, Moen LM, Ledsaak M, Eskeland R, Gabrielsen OS. Rodríguez-Castañeda F, et al. J Biol Chem. 2018 Oct 5;293(40):15439-15454. doi: 10.1074/jbc.RA118.002844. Epub 2018 Aug 6. J Biol Chem. 2018. PMID: 30082317 Free PMC article.
In the present work, we focused on SENP1, specifically, on its role in activation of gene expression investigated through analysis of the SENP1 interactome, which revealed that SENP1 physically interacts with the chromatin remodeler chromodomain helicase DNA-binding …
In the present work, we focused on SENP1, specifically, on its role in activation of gene expression investigated through analysis
Expression of Human Cytomegalovirus IE1 Leads to Accumulation of Mono-SUMOylated PML That Is Protected from Degradation by Herpes Simplex Virus 1 ICP0.
Hou W, Cruz-Cosme R, Wen F, Ahn JH, Reeves I, Luo MH, Tang Q. Hou W, et al. J Virol. 2018 Nov 12;92(23):e01452-18. doi: 10.1128/JVI.01452-18. Print 2018 Dec 1. J Virol. 2018. PMID: 30258013 Free PMC article.
An in vitro study found that IE1 with mutation of L174P failed to deSUMOylate PML and did not protect PML from degradation by ICP0; hence, we conclude that the deSUMOylation of PML is important for IE1 to protect PML from degradation by ICP0. ...Whether the mono-SUM …
An in vitro study found that IE1 with mutation of L174P failed to deSUMOylate PML and did not protect PML from degradation by ICP0; h …
Ethanol Exposure Induces Microglia Activation and Neuroinflammation through TLR4 Activation and SENP6 Modulation in the Adolescent Rat Hippocampus.
Li Q, Liu D, Pan F, Ho CSH, Ho RCM. Li Q, et al. Neural Plast. 2019 Nov 12;2019:1648736. doi: 10.1155/2019/1648736. eCollection 2019. Neural Plast. 2019. PMID: 31781182 Free PMC article.
This study investigates the effects of long-term ethanol consumption on neuroinflammation in the hippocampus of adolescent rats and the regulatory roles of TLR4 and SENP6. ...Proinflammatory cytokines including TNF-α, IL-1β, and IL-6 were measured by enzyme-linked i …
This study investigates the effects of long-term ethanol consumption on neuroinflammation in the hippocampus of adolescent rats and t …
Differential Expression of Seven De-sumoylation Enzymes (SENPs) in Major Ocular Tissues of Mouse Eye.
Xiang JW, Zhang L, Tang X, Xiao Y, Liu Y, Wang L, Liu F, Gong XD, Fu JL, Yang L, Luo Z, Li DW. Xiang JW, et al. Curr Mol Med. 2018;18(8):533-541. doi: 10.2174/1566524019666190112132103. Curr Mol Med. 2018. PMID: 30636607
However, the biological significance of seven SENP enzymes: SENP1 to 3 and SENP5 to 8 have not be fully investigated in the ocular tissues. ...CONCLUSION: Our results for the first time established the differentiation expression patterns of the 7 de-sumoylati …
However, the biological significance of seven SENP enzymes: SENP1 to 3 and SENP5 to 8 have not be fully investigated in …
Decreased SUMOylation of the retinoblastoma protein in keratinocytes during the pathogenesis of vitiligo.
Zhou M, Lin F, Xu W, Jin R, Xu A. Zhou M, et al. Mol Med Rep. 2018 Sep;18(3):3469-3475. doi: 10.3892/mmr.2018.9299. Epub 2018 Jul 19. Mol Med Rep. 2018. PMID: 30066925
The protein expression of SUMO1, SUMO‑specific peptidase 1 (SENP1), ubiquitin‑conjugating enzyme E2 I (Ubc9), SUMO‑activating enzyme subunit 1 (SAE1), cyclin‑dependent kinase (CDK)2, CDK6, proliferating cell nuclear antigen (PCNA), retinoblastoma protein (Rb), phosp …
The protein expression of SUMO1, SUMO‑specific peptidase 1 (SENP1), ubiquitin‑conjugating enzyme E2 I (Ubc9), SUMO‑activating enzy
Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation.
Wu J, Lei H, Zhang J, Chen X, Tang C, Wang W, Xu H, Xiao W, Gu W, Wu Y. Wu J, et al. Oncotarget. 2016 Sep 13;7(37):58995-59005. doi: 10.18632/oncotarget.10636. Oncotarget. 2016. PMID: 27449295 Free PMC article.
Mc also altered the thermal stability of SENP1 in a newly developed cellular thermal shift assay, indicating that Mc directly interacts with SENP1 in PCa cells. ...Investigation of other pentacyclic triterpenoids may aid in the development of novel SENP1 inhibitor d …
Mc also altered the thermal stability of SENP1 in a newly developed cellular thermal shift assay, indicating that Mc directly interac …
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