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Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications.
Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ, Stacey GN. Andrews PW, et al. Stem Cell Reports. 2017 Jul 11;9(1):1-4. doi: 10.1016/j.stemcr.2017.05.029. Stem Cell Reports. 2017. PMID: 28700896 Free PMC article.
Pluripotent stem cells may acquire genetic and epigenetic variants during culture following their derivation. At a conference organized by the International Stem Cell Initiative, and held at The Jackson Laboratory, Bar Harbor, Maine, October 201
Pluripotent stem cells may acquire genetic and epigenetic variants during culture following their derivation. At
The multi-functional roles of menstrual blood-derived stem cells in regenerative medicine.
Chen L, Qu J, Xiang C. Chen L, et al. Stem Cell Res Ther. 2019 Jan 3;10(1):1. doi: 10.1186/s13287-018-1105-9. Stem Cell Res Ther. 2019. PMID: 30606242 Free PMC article. Review.
Menstrual blood-derived stem cells (MenSCs) are a novel source of mesenchymal stem cells (MSCs). ...In summary, MenSC has a great potential for reducing mortality and improving the quality of life of severe patients. As a kind of adult stem
Menstrual blood-derived stem cells (MenSCs) are a novel source of mesenchymal stem cells (MSCs). ...In su …
Potential Applications of Induced Pluripotent Stem Cells for Cardiovascular Diseases.
Wang X, Han Z, Yu Y, Xu Z, Cai B, Yuan Y. Wang X, et al. Curr Drug Targets. 2019;20(7):763-774. doi: 10.2174/1389450120666181211164147. Curr Drug Targets. 2019. PMID: 30539693 Review.
Owning the high incidence and disability rate in the past decades, to be expected, cardiovascular diseases (CVDs) have become one of the leading death causes worldwide. Currently, induced pluripotent stem cells (iPSCs), with the potential to form fresh myocar …
Owning the high incidence and disability rate in the past decades, to be expected, cardiovascular diseases (CVDs) have become one of the lea …
Concise Review: Assessing the Genome Integrity of Human Induced Pluripotent Stem Cells: What Quality Control Metrics?
Assou S, Bouckenheimer J, De Vos J. Assou S, et al. Stem Cells. 2018 Jun;36(6):814-821. doi: 10.1002/stem.2797. Epub 2018 Feb 18. Stem Cells. 2018. PMID: 29441649 Free article. Review.
Human induced pluripotent stem cells (hiPSCs) have the potential to differentiate virtually into any cell type in unlimited quantities. ...Stem Cells 2018;36:814-821....
Human induced pluripotent stem cells (hiPSCs) have the potential to differentiate virtually into any cell type i
CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells.
Jacków J, Guo Z, Hansen C, Abaci HE, Doucet YS, Shin JU, Hayashi R, DeLorenzo D, Kabata Y, Shinkuma S, Salas-Alanis JC, Christiano AM. Jacków J, et al. Proc Natl Acad Sci U S A. 2019 Dec 9;116(52):26846-52. doi: 10.1073/pnas.1907081116. Online ahead of print. Proc Natl Acad Sci U S A. 2019. PMID: 31818947 Free PMC article.
We used the clustered regulatory interspaced short palindromic repeats (CRISPR) Cas9-gRNAs system to modify induced pluripotent stem cells (iPSCs) derived from patients with RDEB in both the heterozygous and homozygous states. ...Our findings represent …
We used the clustered regulatory interspaced short palindromic repeats (CRISPR) Cas9-gRNAs system to modify induced pluripotent st
The role of the reprogramming method and pluripotency state in gamete differentiation from patient-specific human pluripotent stem cells.
Mishra S, Kacin E, Stamatiadis P, Franck S, Van der Jeught M, Mertes H, Pennings G, De Sutter P, Sermon K, Heindryckx B, Geens M. Mishra S, et al. Mol Hum Reprod. 2018 Apr 1;24(4):173-184. doi: 10.1093/molehr/gay007. Mol Hum Reprod. 2018. PMID: 29471503
The derivation of gametes from patient-specific pluripotent stem cells may provide new perspectives for genetic parenthood for patients currently facing sterility. We use current data to assess the gamete differentiation potential of patient-spe …
The derivation of gametes from patient-specific pluripotent stem cells may provide new perspectives for genetic …
Acquired Genetic and Epigenetic Variation in Human Pluripotent Stem Cells.
Kyriakides O, Halliwell JA, Andrews PW. Kyriakides O, et al. Adv Biochem Eng Biotechnol. 2018;163:187-206. doi: 10.1007/10_2017_22. Adv Biochem Eng Biotechnol. 2018. PMID: 29071402 Free article. Review.
Human pluripotent stem cells (hPSCs) can acquire non-random genomic variation during culture. Some of these changes are common in tumours and confer a selective growth advantage in culture. Additionally, there is evidence that reprogramming of human
Human pluripotent stem cells (hPSCs) can acquire non-random genomic variation during culture. Some of these chan
Potential applications of keratinocytes derived from human embryonic stem cells.
Movahednia MM, Kidwai FK, Jokhun DS, Squier CA, Toh WS, Cao T. Movahednia MM, et al. Biotechnol J. 2016 Jan;11(1):58-70. doi: 10.1002/biot.201500099. Epub 2015 Dec 10. Biotechnol J. 2016. PMID: 26663861 Review.
Furthermore, we discuss the industrial applications of hESC-derived keratinized multi-layer epithelium which provides a human-like test platform for understanding disease pathogenesis, evaluation of new therapeutic modalities and assessment of the s
Furthermore, we discuss the industrial applications of hESC-derived keratinized multi-layer epithelium which provides a hum
Novel Stem Cell Therapies for Applications to Wound Healing and Tissue Repair.
Grada A, Falanga V. Grada A, et al. Surg Technol Int. 2016 Oct 26;29:29-37. Surg Technol Int. 2016. PMID: 27728944 Review.
However, the treatment outcomes are not always ideal because of failure to achieve complete wound closure in around 60% of cases, scarring, and high rate of recurrence. Therefore, there is a need for more effective therapies. Stem cells offer promising possibilities …
However, the treatment outcomes are not always ideal because of failure to achieve complete wound closure in around 60% of cases, scarring, …
Molecular characterization of bovine amniotic fluid derived stem cells with an underlying focus on their comparative neuronal potential at different passages.
Nawaz S, Özden Akkaya Ö, Dikmen T, Altunbaş K, Yağci A, Kibria ASMG, Erdoğan M, Çelik HA. Nawaz S, et al. Ann Anat. 2020 Mar;228:151452. doi: 10.1016/j.aanat.2019.151452. Epub 2019 Nov 26. Ann Anat. 2020. PMID: 31778790
BACKGROUND: The excellence in the field of stem cell therapy demands alternative and more convenient stem cells for potential applications. Researchers have opted for least invasive and broadly multipotent cells with minimum ethical concerns. Bo …
BACKGROUND: The excellence in the field of stem cell therapy demands alternative and more convenient stem cells for pot …
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