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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1992 1
1995 3
1996 1
1997 5
1998 1
1999 4
2001 4
2002 2
2003 7
2004 4
2005 8
2006 10
2007 12
2008 6
2009 10
2010 15
2011 12
2012 15
2013 13
2014 10
2015 12
2016 14
2017 11
2018 14
2019 13
2020 10
2021 12
2022 5
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202 results
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Assessment of the genetic variance of late-onset Alzheimer's disease.
Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Kauwe JSK; Alzheimer's Disease Genetics Consortium (ADGC). Ridge PG, et al. Neurobiol Aging. 2016 May;41:200.e13-200.e20. doi: 10.1016/j.neurobiolaging.2016.02.024. Epub 2016 Mar 3. Neurobiol Aging. 2016. PMID: 27036079 Free PMC article.
Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. ...Of the unexplained genetic variance, approximately 41% is explained by unknown SNPs in regions adjacent to known AD SNPs, and the remaining unexplaine
Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. ...Of the unexplained ge
The role of ABCA7 in Alzheimer's disease: evidence from genomics, transcriptomics and methylomics.
De Roeck A, Van Broeckhoven C, Sleegers K. De Roeck A, et al. Acta Neuropathol. 2019 Aug;138(2):201-220. doi: 10.1007/s00401-019-01994-1. Epub 2019 Mar 22. Acta Neuropathol. 2019. PMID: 30903345 Free PMC article. Review.
Genome-wide association studies (GWAS) originally identified ATP-binding cassette, sub-family A, member 7 (ABCA7), as a novel risk gene of Alzheimer's disease (AD). Since then, accumulating evidence from in vitro, in vivo, and human-based studies has corrobor …
Genome-wide association studies (GWAS) originally identified ATP-binding cassette, sub-family A, member 7 (ABCA7), as a novel risk gene of …
Explore the role of CR1 genetic variants in late-onset Alzheimer's disease susceptibility.
Lu L, Yao QY, Ruan SS, Hu JW, Long WJ, Dai WZ, Ma T, Zhu XC. Lu L, et al. Psychiatr Genet. 2021 Dec 1;31(6):216-229. doi: 10.1097/YPG.0000000000000291. Psychiatr Genet. 2021. PMID: 34347684
BACKGROUND: Complement component (3b/4b) receptor 1 (CR1) is an interesting candidate gene which has a close connection with Alzheimer's disease, and its polymorphisms have been reported to link to the late-onset Alzheimer's dis
BACKGROUND: Complement component (3b/4b) receptor 1 (CR1) is an interesting candidate gene which has a close connection with Alzheimer
Genetic analyses of early-onset Alzheimer's disease using next generation sequencing.
Giau VV, Bagyinszky E, Yang YS, Youn YC, An SSA, Kim SY. Giau VV, et al. Sci Rep. 2019 Jun 10;9(1):8368. doi: 10.1038/s41598-019-44848-2. Sci Rep. 2019. PMID: 31182772 Free PMC article.
Alzheimer's disease (AD) is the most common type of neurodegenerative dementia, but the cause of AD remained poorly understood. ...Additionally, 67 missense mutations in susceptibility genes for late-onset AD were identified, which may be involv
Alzheimer's disease (AD) is the most common type of neurodegenerative dementia, but the cause of AD remained poorly und
Dissecting the role of Amerindian genetic ancestry and the ApoE ε4 allele on Alzheimer disease in an admixed Peruvian population.
Marca-Ysabel MV, Rajabli F, Cornejo-Olivas M, Whitehead PG, Hofmann NK, Illanes Manrique MZ, Veliz Otani DM, Milla Neyra AK, Castro Suarez S, Meza Vega M, Adams LD, Mena PR, Rosario I, Cuccaro ML, Vance JM, Beecham GW, Custodio N, Montesinos R, Mazzetti Soler PE, Pericak-Vance MA. Marca-Ysabel MV, et al. Neurobiol Aging. 2021 May;101:298.e11-298.e15. doi: 10.1016/j.neurobiolaging.2020.10.003. Epub 2020 Dec 10. Neurobiol Aging. 2021. PMID: 33541779 Free PMC article.
Alzheimer disease (AD) is the leading cause of dementia in the elderly and occurs in all ethnic and racial groups. The apolipoprotein E (ApoE) epsilon4 is the most significant genetic risk factor for late-onset AD and shows the strongest effect
Alzheimer disease (AD) is the leading cause of dementia in the elderly and occurs in all ethnic and racial groups. The apolipo
Functional annotation of genomic variants in studies of late-onset Alzheimer's disease.
Butkiewicz M, Blue EE, Leung YY, Jian X, Marcora E, Renton AE, Kuzma A, Wang LS, Koboldt DC, Haines JL, Bush WS. Butkiewicz M, et al. Bioinformatics. 2018 Aug 15;34(16):2724-2731. doi: 10.1093/bioinformatics/bty177. Bioinformatics. 2018. PMID: 29590295 Free PMC article.
Computational predictions of variant function are routinely incorporated into gene-based analyses of rare-variants, though to date most studies use limited information for assessing variant function that is often agnostic of the disease being studied. RESULTS: In th …
Computational predictions of variant function are routinely incorporated into gene-based analyses of rare-variants, though to date most stud …
Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese.
Chang XL, Tan L, Tan MS, Wang HF, Tan CC, Zhang W, Zheng ZJ, Kong LL, Wang ZX, Jiang T, Yu JT, Tan L. Chang XL, et al. Oncotarget. 2016 Apr 19;7(16):22746-51. doi: 10.18632/oncotarget.8176. Oncotarget. 2016. PMID: 27009838 Free PMC article.
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) acts as a potential genetic modifier for Alzheimer's disease (AD). Previous reports identified that HMGCR rs3846662 polymorphism is associated with biosynthesis of cholesterol in AD pathology. In ord …
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) acts as a potential genetic modifier for Alzheimer's disease
Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study.
Andrews SJ, Das D, Anstey KJ, Easteal S. Andrews SJ, et al. J Alzheimers Dis. 2017;57(2):423-436. doi: 10.3233/JAD-160774. J Alzheimers Dis. 2017. PMID: 28269768
Recent genome wide association studies have identified a number of single nucleotide polymorphisms associated with late onset Alzheimer's disease (LOAD). We examined the associations of 24 LOAD risk loci, individually and collectively as a ge
Recent genome wide association studies have identified a number of single nucleotide polymorphisms associated with late onset
Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population.
Omoumi A, Fok A, Greenwood T, Sadovnick AD, Feldman HH, Hsiung GY. Omoumi A, et al. Neurobiol Aging. 2014 Apr;35(4):936.e5-12. doi: 10.1016/j.neurobiolaging.2013.09.025. Epub 2013 Oct 28. Neurobiol Aging. 2014. PMID: 24176626
We performed case-control studies using 2 Canadian cohorts to examine the role of 10 promising Alzheimer's disease (AD) loci identified in recent genomewide association studies. ...In addition, pooled analysis of our AD patients confirmed that CR1, TOMM40, BI …
We performed case-control studies using 2 Canadian cohorts to examine the role of 10 promising Alzheimer's disease (AD) …
Lack of genetic support for shared aetiology of Coronary Artery Disease and Late-onset Alzheimer's disease.
Grace C, Clarke R, Goel A, Farrall M, Watkins H, Hopewell JC. Grace C, et al. Sci Rep. 2018 May 8;8(1):7102. doi: 10.1038/s41598-018-25460-2. Sci Rep. 2018. PMID: 29740026 Free PMC article.
Epidemiological studies suggest a positive association between coronary artery disease (CAD) and late-onset Alzheimer's disease (LOAD). This large-scale genetic study brings together 'big data' resources to examine the causal impac …
Epidemiological studies suggest a positive association between coronary artery disease (CAD) and late-onset Alzheime
202 results