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213 results

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Page 1
Educational attainment, structural brain reserve and Alzheimer's disease: a Mendelian randomization analysis.
Seyedsalehi A, Warrier V, Bethlehem RAI, Perry BI, Burgess S, Murray GK. Seyedsalehi A, et al. Brain. 2023 May 2;146(5):2059-2074. doi: 10.1093/brain/awac392. Brain. 2023. PMID: 36310536 Free PMC article.
We conducted univariable Mendelian randomization analyses to investigate bidirectional associations between (i) educational attainment and Alzheimer's disease; (ii) educational attainment and imaging-derived phenotypes; and (iii) imaging-derived phenotypes an …
We conducted univariable Mendelian randomization analyses to investigate bidirectional associations between (i) educational attainment and …
Assessment of the genetic variance of late-onset Alzheimer's disease.
Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Kauwe JSK; Alzheimer's Disease Genetics Consortium (ADGC). Ridge PG, et al. Neurobiol Aging. 2016 May;41:200.e13-200.e20. doi: 10.1016/j.neurobiolaging.2016.02.024. Epub 2016 Mar 3. Neurobiol Aging. 2016. PMID: 27036079 Free PMC article.
Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. ...Of the unexplained genetic variance, approximately 41% is explained by unknown SNPs in regions adjacent to known AD SNPs, and the remaining unexplaine
Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. ...Of the unexplained ge
Explore the role of CR1 genetic variants in late-onset Alzheimer's disease susceptibility.
Lu L, Yao QY, Ruan SS, Hu JW, Long WJ, Dai WZ, Ma T, Zhu XC. Lu L, et al. Psychiatr Genet. 2021 Dec 1;31(6):216-229. doi: 10.1097/YPG.0000000000000291. Psychiatr Genet. 2021. PMID: 34347684
BACKGROUND: Complement component (3b/4b) receptor 1 (CR1) is an interesting candidate gene which has a close connection with Alzheimer's disease, and its polymorphisms have been reported to link to the late-onset Alzheimer's dis
BACKGROUND: Complement component (3b/4b) receptor 1 (CR1) is an interesting candidate gene which has a close connection with Alzheimer
Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90.
Heath L, Earls JC, Magis AT, Kornilov SA, Lovejoy JC, Funk CC, Rappaport N, Logsdon BA, Mangravite LM, Kunkle BW, Martin ER, Naj AC, Ertekin-Taner N, Golde TE, Hood L, Price ND; Alzheimer’s Disease Genetics Consortium. Heath L, et al. Sci Rep. 2022 Apr 12;12(1):6117. doi: 10.1038/s41598-022-09825-2. Sci Rep. 2022. PMID: 35413975 Free PMC article.
Genetics play an important role in late-onset Alzheimer's Disease (AD) etiology and dozens of genetic variants have been implicated in AD risk through large-scale GWAS meta-analyses. ...Known AD genetic variation influenced …
Genetics play an important role in late-onset Alzheimer's Disease (AD) etiology and dozens of genetic
Genetic analyses of early-onset Alzheimer's disease using next generation sequencing.
Giau VV, Bagyinszky E, Yang YS, Youn YC, An SSA, Kim SY. Giau VV, et al. Sci Rep. 2019 Jun 10;9(1):8368. doi: 10.1038/s41598-019-44848-2. Sci Rep. 2019. PMID: 31182772 Free PMC article.
Alzheimer's disease (AD) is the most common type of neurodegenerative dementia, but the cause of AD remained poorly understood. ...Additionally, 67 missense mutations in susceptibility genes for late-onset AD were identified, which may be involv
Alzheimer's disease (AD) is the most common type of neurodegenerative dementia, but the cause of AD remained poorly und
The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes.
Chiba-Falek O, Gottschalk WK, Lutz MW. Chiba-Falek O, et al. Alzheimers Dement. 2018 May;14(5):692-698. doi: 10.1016/j.jalz.2018.01.015. Epub 2018 Mar 7. Alzheimers Dement. 2018. PMID: 29524426 Free PMC article. Review.
Roses et al. identified the association between the length of TOMM40 poly-T with the risk and age of onset of late-onset Alzheimer's disease (LOAD). Following the original discovery, additional studies found associations between the TOMM40 poly- …
Roses et al. identified the association between the length of TOMM40 poly-T with the risk and age of onset of late-onset Al
Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD.
Carrasquillo MM, Khan Qu, Murray ME, Krishnan S, Aakre J, Pankratz VS, Nguyen T, Ma L, Bisceglio G, Petersen RC, Younkin SG, Dickson DW, Boeve BF, Graff-Radford NR, Ertekin-Taner N. Carrasquillo MM, et al. Neurology. 2014 Apr 22;82(16):1455-62. doi: 10.1212/WNL.0000000000000335. Epub 2014 Mar 26. Neurology. 2014. PMID: 24670887 Free PMC article.
OBJECTIVE: To investigate association of genetic risk factors for late-onset Alzheimer disease (LOAD) with risk of posterior cortical atrophy (PCA), a syndrome of visual impairment with predominant Alzheimer disease (AD) pathology …
OBJECTIVE: To investigate association of genetic risk factors for late-onset Alzheimer disease (LOAD) wit …
Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese.
Chang XL, Tan L, Tan MS, Wang HF, Tan CC, Zhang W, Zheng ZJ, Kong LL, Wang ZX, Jiang T, Yu JT, Tan L. Chang XL, et al. Oncotarget. 2016 Apr 19;7(16):22746-51. doi: 10.18632/oncotarget.8176. Oncotarget. 2016. PMID: 27009838 Free PMC article.
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) acts as a potential genetic modifier for Alzheimer's disease (AD). Previous reports identified that HMGCR rs3846662 polymorphism is associated with biosynthesis of cholesterol in AD pathology. In ord …
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) acts as a potential genetic modifier for Alzheimer's disease
Functional annotation of genomic variants in studies of late-onset Alzheimer's disease.
Butkiewicz M, Blue EE, Leung YY, Jian X, Marcora E, Renton AE, Kuzma A, Wang LS, Koboldt DC, Haines JL, Bush WS. Butkiewicz M, et al. Bioinformatics. 2018 Aug 15;34(16):2724-2731. doi: 10.1093/bioinformatics/bty177. Bioinformatics. 2018. PMID: 29590295 Free PMC article.
Computational predictions of variant function are routinely incorporated into gene-based analyses of rare-variants, though to date most studies use limited information for assessing variant function that is often agnostic of the disease being studied. RESULTS: In th …
Computational predictions of variant function are routinely incorporated into gene-based analyses of rare-variants, though to date most stud …
Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease.
Ramadan FA, Arani G, Jafri A, Thompson T, Bland VL, Renquist B, Raichlen DA, Alexander GE, Klimentidis YC. Ramadan FA, et al. J Alzheimers Dis. 2024;98(3):1069-1078. doi: 10.3233/JAD-231063. J Alzheimers Dis. 2024. PMID: 38489176
BACKGROUND: Late-onset Alzheimer's disease (LOAD) represents a growing health burden. ...OBJECTIVE: We used a genetics-based study design which may overcome limitations of other epidemiological studies to assess the influence of metabolit …
BACKGROUND: Late-onset Alzheimer's disease (LOAD) represents a growing health burden. ...OBJECTIVE: We us …
213 results