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Association of Vitamin B12, Folate, and Sulfur Amino Acids With Brain Magnetic Resonance Imaging Measures in Older Adults: A Longitudinal Population-Based Study.
Hooshmand B, Mangialasche F, Kalpouzos G, Solomon A, Kåreholt I, Smith AD, Refsum H, Wang R, Mühlmann M, Ertl-Wagner B, Laukka EJ, Bäckman L, Fratiglioni L, Kivipelto M. Hooshmand B, et al. JAMA Psychiatry. 2016 Jun 1;73(6):606-13. doi: 10.1001/jamapsychiatry.2016.0274. JAMA Psychiatry. 2016. PMID: 27120188
IMPORTANCE: Vitamin B12, folate, and sulfur amino acids may be modifiable risk factors for structural brain changes that precede clinical dementia. OBJECTIVE: To investigate the association of circulating levels of vitami
IMPORTANCE: Vitamin B12, folate, and sulfur amino acids may be modifiable risk factors for structu …
Association of Methionine to Homocysteine Status With Brain Magnetic Resonance Imaging Measures and Risk of Dementia.
Hooshmand B, Refsum H, Smith AD, Kalpouzos G, Mangialasche F, von Arnim CAF, Kåreholt I, Kivipelto M, Fratiglioni L. Hooshmand B, et al. JAMA Psychiatry. 2019 Nov 1;76(11):1198-1205. doi: 10.1001/jamapsychiatry.2019.1694. JAMA Psychiatry. 2019. PMID: 31339527 Free PMC article.
IMPORTANCE: Impairment of methylation status (ie, methionine to homocysteine ratio) may be a modifiable risk factor for structural brain changes and incident dementia. OBJECTIVE: To investigate the association of serum markers of methylation status and sulfur
IMPORTANCE: Impairment of methylation status (ie, methionine to homocysteine ratio) may be a modifiable risk factor for structural brain
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.
Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, Oulhaj A, Bradley KM, Jacoby R, Refsum H. Smith AD, et al. PLoS One. 2010 Sep 8;5(9):e12244. doi: 10.1371/journal.pone.0012244. PLoS One. 2010. PMID: 20838622 Free PMC article. Clinical Trial.
METHODS AND FINDINGS: Single-center, randomized, double-blind controlled trial of high-dose folic acid, vitamins B(6) and B(12) in 271 individuals (of 646 screened) over 70 y old with mild cognitive impairment. ...Participants were randomly assi …
METHODS AND FINDINGS: Single-center, randomized, double-blind controlled trial of high-dose folic acid, vitamins B(6) a …
Folate and Vitamin B(12)-Related Biomarkers in Relation to Brain Volumes.
van der Zwaluw NL, Brouwer-Brolsma EM, van de Rest O, van Wijngaarden JP, In 't Veld PH, Kourie DI, Swart KM, Enneman AW, van Dijk SC, van der Velde N, Kessels RP, Smeets PA, Kok FJ, Dhonukshe-Rutten RA, de Groot LC. van der Zwaluw NL, et al. Nutrients. 2016 Dec 24;9(1):8. doi: 10.3390/nu9010008. Nutrients. 2016. PMID: 28029114 Free PMC article. Clinical Trial.
AIM: We investigated cross-sectional associations between circulating homocysteine, folate, biomarkers of vitamin B(12) status and brain volumes. ...Plasma homocysteine, serum folate, vitamin B(12), holotransco …
AIM: We investigated cross-sectional associations between circulating homocysteine, folate, biomarkers of vitamin B
Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample.
Sachdev PS, Parslow RA, Lux O, Salonikas C, Wen W, Naidoo D, Christensen H, Jorm AF. Sachdev PS, et al. Psychol Med. 2005 Apr;35(4):529-38. doi: 10.1017/s0033291704003721. Psychol Med. 2005. PMID: 15856723
Vitamin B12 levels did not have a significant association with depressive symptoms. ...CONCLUSIONS: Low folic acid and high homocysteine, but not low vitamin B12 levels, are correlates of depressive symptoms in community-dwelling m
Vitamin B12 levels did not have a significant association with depressive symptoms. ...CONCLUSIONS: Low folic
Correlations between folate, B12, homocysteine levels, and radiological markers of neuropathology in elderly post-stroke patients.
Yang LK, Wong KC, Wu MY, Liao SL, Kuo CS, Huang RF. Yang LK, et al. J Am Coll Nutr. 2007 Jun;26(3):272-8. doi: 10.1080/07315724.2007.10719611. J Am Coll Nutr. 2007. PMID: 17634173
Circulating levels of folate, B12, and tHcy were measured. Magnetic resonance imaging (MRI) or computed tomography (CT) was used for evaluation of brain lesions including infarction and atrophy. ...No significant association
Circulating levels of folate, B12, and tHcy were measured. Magnetic resonance imaging (MRI) or com …
Homocysteine and the brain in midadult life: evidence for an increased risk of leukoaraiosis in men.
Sachdev P, Parslow R, Salonikas C, Lux O, Wen W, Kumar R, Naidoo D, Christensen H, Jorm A. Sachdev P, et al. Arch Neurol. 2004 Sep;61(9):1369-76. doi: 10.1001/archneur.61.9.1369. Arch Neurol. 2004. PMID: 15364682
MAIN OUTCOME MEASURES: Regression coefficients with HCY level as the putative determinant and various magnetic resonance imaging measures (brain atrophy index, ventricle-brain ratios, volume of periventricular and deep white matter …
MAIN OUTCOME MEASURES: Regression coefficients with HCY level as the putative determinant and various magnetic resonance
Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study.
Faux NG, Ellis KA, Porter L, Fowler CJ, Laws SM, Martins RN, Pertile KK, Rembach A, Rowe CC, Rumble RL, Szoeke C, Taddei K, Taddei T, Trounson BO, Villemagne VL, Ward V, Ames D, Masters CL, Bush AI. Faux NG, et al. J Alzheimers Dis. 2011;27(4):909-22. doi: 10.3233/JAD-2011-110752. J Alzheimers Dis. 2011. PMID: 21891867
There is some debate regarding the differing levels of plasma homocysteine, vitamin B12 and serum folate between healthy controls (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD). As part of the Australian Imaging Biomarker Li …
There is some debate regarding the differing levels of plasma homocysteine, vitamin B12 and serum folate between health …
Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part II).
Papakostas GI, Iosifescu DV, Renshaw PF, Lyoo IK, Lee HK, Alpert JE, Nierenberg AA, Fava M. Papakostas GI, et al. Psychiatry Res. 2005 Dec 30;140(3):301-7. doi: 10.1016/j.pscychresns.2005.09.001. Epub 2005 Nov 16. Psychiatry Res. 2005. PMID: 16297603
Fifty MDD subjects were administered brain magnetic resonance imaging (MRI) scans at 1.5 T to detect T2 WMHs. ...MDD patients also had serum folate, vitamin B12 and homocysteine levels measured. All MDD subjects received tre …
Fifty MDD subjects were administered brain magnetic resonance imaging (MRI) scans at 1.5 T to detect T2 WMHs. .. …
Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults.
Feng L, Isaac V, Sim S, Ng TP, Krishnan KR, Chee MW. Feng L, et al. Am J Geriatr Psychiatry. 2013 Feb;21(2):164-72. doi: 10.1016/j.jagp.2012.10.017. Epub 2013 Jan 22. Am J Geriatr Psychiatry. 2013. PMID: 23343490
Persons with medical conditions or neurological diseases other than well-controlled diabetes mellitus and hypertension were excluded. Participants underwent quantitative magnetic resonance imaging of the brain using a standardized protocol and neuropsy …
Persons with medical conditions or neurological diseases other than well-controlled diabetes mellitus and hypertension were excluded. Partic …
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