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[FILAGGRIN GENE NULL-MUTATIONS AND ATOPIC DISEASES].
Pipinić IS, Macan J. Pipinić IS, et al. Acta Med Croatica. 2015;69(5):467-73. Acta Med Croatica. 2015. PMID: 29087092 Review. Croatian.
Null-mutations which cause loss of function of the gene encoding filaggrin (FLG) have been strongly linked to the development of atopic disorders, predominantly atopic eczema/dermatitis syndrome (AEDS). ...Epidemiological studies indicate an
Null-mutations which cause loss of function of the gene encoding filaggrin (FLG) have been strongly linke
Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence.
Venkataraman D, Soto-Ramírez N, Kurukulaaratchy RJ, Holloway JW, Karmaus W, Ewart SL, Arshad SH, Erlewyn-Lajeunesse M. Venkataraman D, et al. J Allergy Clin Immunol. 2014 Oct;134(4):876-882.e4. doi: 10.1016/j.jaci.2014.07.033. Epub 2014 Aug 28. J Allergy Clin Immunol. 2014. PMID: 25174864 Free PMC article.
BACKGROUND: Filaggrin is an epidermal protein that has a role in skin barrier function. Filaggrin loss-of-function (FLG-LOF) mutations are a significant risk factor for eczema and atopy, but their association with food aller …
BACKGROUND: Filaggrin is an epidermal protein that has a role in skin barrier function. Filaggrin loss-of-fun
Filaggrin gene loss-of-function mutations explain discordance of atopic dermatitis within dizygotic twin pairs.
Thomsen SF, Elmose C, Szecsi PB, Stender S, Kyvik KO, Backer V, Thyssen JP. Thomsen SF, et al. Int J Dermatol. 2016 Dec;55(12):1341-1344. doi: 10.1111/ijd.13401. Epub 2016 Sep 22. Int J Dermatol. 2016. PMID: 27653621
OBJECTIVES: This study was designed to examine the association between loss-of-function mutations in the filaggrin gene (FLG) and atopic dermatitis (AD) and asthma in adult twins. METHODS: A previously well-characterized cohort of 575 adult twin …
OBJECTIVES: This study was designed to examine the association between loss-of-function mutations in the fila
Usefulness of a global clinical ichthyosis vulgaris scoring system for predicting common FLG null mutations in an adult caucasian population.
Ezzedine K, Droitcourt C, Ged C, Diallo A, Hubiche T, de Verneuil H, Boralevi F, Taïeb A. Ezzedine K, et al. Br J Dermatol. 2012 Nov;167(5):1165-9. doi: 10.1111/j.1365-2133.2012.11062.x. Epub 2012 Sep 7. Br J Dermatol. 2012. PMID: 22612618
OBJECTIVES: To identify independent factors associated with the clinical IV phenotype in adult caucasian patients with AD and to assess the performance of a global clinical severity score of IV in predicting common FLG null mutations. ...Using multivar …
OBJECTIVES: To identify independent factors associated with the clinical IV phenotype in adult caucasian patients with AD and to asse …
Atopic eczema or atopiform dermatitis.
Bos JD, Brenninkmeijer EE, Schram ME, Middelkamp-Hup MA, Spuls PI, Smitt JH. Bos JD, et al. Exp Dermatol. 2010 Apr;19(4):325-31. doi: 10.1111/j.1600-0625.2009.01024.x. Epub 2010 Jan 22. Exp Dermatol. 2010. PMID: 20100192 Free article. Review.
Recent steps in understanding AE are the detection of skin barrier related filaggrin null mutations in approximately 25% of patients and the recognition of IL-31 as a molecule possibly involved in the itch (pruritus). ...Advice as to the need for elimination …
Recent steps in understanding AE are the detection of skin barrier related filaggrin null mutations in approximately 25 …