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Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease.
European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration; Luo J, Thomassen JQ, Bellenguez C, Grenier-Boley B, de Rojas I, Castillo A, Parveen K, Küçükali F, Nicolas A, Peters O, Schneider A, Dichgans M, Rujescu D, Scherbaum N, Jürgen D, Riedel-Heller S, Hausner L, Porcel LM, Düzel E, Grimmer T, Wiltfang J, Heilmann-Heimbach S, Moebus S, Tegos T, Scarmeas N, Clarimon J, Moreno F, Pérez-Tur J, Bullido MJ, Pastor P, Sánchez-Valle R, Álvarez V, Boada M, García-González P, Puerta R, Mir P, Real LM, Piñol-Ripoll G, García-Alberca JM, Royo JL, Rodriguez-Rodriguez E, Soininen H, Kuulasmaa T, de Mendonça A, Mehrabian S, Hort J, Vyhnalek M, van der Lee S, Graff C, Papenberg G, Giedraitis V, Boland A, Bacq-Daian D, Deleuze JF, Nicolas G, Dufouil C, Pasquier F, Hanon O, Debette S, Grünblatt E, Popp J, Benussi L, Galimberti D, Arosio B, Mecocci P, Solfrizzi V, Parnetti L, Squassina A, Tremolizzo L, Borroni B, Nacmias B, Sorbi S, Caffarra P, Seripa D, Rainero I, Daniele A, Masullo C, Spalletta G, Williams J, Amouyel P, Jessen F, Kehoe P, Tsolaki M, Rossi G, Sánchez-Juan P, Sleegers K, Ingelsson M, Andreassen OA, Hiltunen M, Van Duijn C, Sims R, van der Flier W… See abstract for full author list ➔ European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration, et al. JAMA Netw Open. 2023 May 1;6(5):e2313734. doi: 10.1001/jamanetworkopen.2023.13734. JAMA Netw Open. 2023. PMID: 37195665 Free PMC article.
IMPORTANCE: An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking. Effective interventions should target risk …
IMPORTANCE: An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the …
Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome.
Andrews SJ, Fulton-Howard B, O'Reilly P, Marcora E, Goate AM; collaborators of the Alzheimer's Disease Genetics Consortium. Andrews SJ, et al. Ann Neurol. 2021 Jan;89(1):54-65. doi: 10.1002/ana.25918. Epub 2020 Oct 15. Ann Neurol. 2021. PMID: 32996171 Free PMC article.
METHODS: Polygenic risk scores (PRS) for the 22 risk factors were computed in 26,431 AD cases/controls and the association with AD was evaluated using logistic regression. Two-sample Mendelian randomization (MR) was used to infer the caus …
METHODS: Polygenic risk scores (PRS) for the 22 risk factors were computed in 26,431 AD cases/controls and the assoc …
Causal relationship between Alzheimer's disease and cardiovascular disease: a bidirectional Mendelian randomization analysis.
Zhang F, Xian D, Feng J, Ning L, Jiang T, Xu W, Liu Y, Zhao Q, Peng M. Zhang F, et al. Aging (Albany NY). 2023 Sep 2;15(17):9022-9040. doi: 10.18632/aging.205013. Epub 2023 Sep 2. Aging (Albany NY). 2023. PMID: 37665672 Free PMC article.
Observational studies suggest that cardiovascular disease (CVD) increases the risk of developing Alzheimer's disease (AD). ...Therefore, these modifiable risk factors are crucial targets for preventing and treating AD....
Observational studies suggest that cardiovascular disease (CVD) increases the risk of developing Alzheimer's …
Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis.
Larsson SC, Traylor M, Malik R, Dichgans M, Burgess S, Markus HS; CoSTREAM Consortium, on behalf of the International Genomics of Alzheimer’s Project. Larsson SC, et al. BMJ. 2017 Dec 6;359:j5375. doi: 10.1136/bmj.j5375. BMJ. 2017. PMID: 29212772 Free PMC article.
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's disease. DESIGN: Mendelian r …
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, c …
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.
Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JR, Boehme KL, Walter S, Kauwe JS, Gibbons LE; Alzheimer’s Disease Genetics Consortium; GERAD1 Consortium; EPIC-InterAct Consortium; Larson EB, Powell JF, Langenberg C, Crane PK, Wareham NJ, Scott RA. Østergaard SD, et al. PLoS Med. 2015 Jun 16;12(6):e1001841; discussion e1001841. doi: 10.1371/journal.pmed.1001841. eCollection 2015 Jun. PLoS Med. 2015. PMID: 26079503 Free PMC article.
BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these …
BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are as …
Associations of cardiovascular risk factors and lifestyle behaviors with neurodegenerative disease: a Mendelian randomization study.
Huang LY, Ou YN, Yang YX, Wang ZT, Tan L, Yu JT. Huang LY, et al. Transl Psychiatry. 2023 Jul 24;13(1):267. doi: 10.1038/s41398-023-02553-9. Transl Psychiatry. 2023. PMID: 37488110 Free PMC article.
This study aimed to investigate the causal associations of cardiovascular risk factors and lifestyle behaviors with neurodegenerative disease, using the two-sample Mendelian randomization design. Genetic variants for the modifia …
This study aimed to investigate the causal associations of cardiovascular risk factors and lifestyle behaviors w …
Immune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases.
Lindbohm JV, Mars N, Sipilä PN, Singh-Manoux A, Runz H; FinnGen; Livingston G, Seshadri S, Xavier R, Hingorani AD, Ripatti S, Kivimäki M. Lindbohm JV, et al. Nat Aging. 2022 Oct;2(10):956-972. doi: 10.1038/s43587-022-00293-x. Epub 2022 Oct 14. Nat Aging. 2022. PMID: 37118290 Free PMC article.
We performed Mendelian randomization for 1,827 immune system- and blood-brain barrier-related biomarkers and identified 127 potential causal risk factors for dementia-causing diseases. ...This association was further supported by human le …
We performed Mendelian randomization for 1,827 immune system- and blood-brain barrier-related biomarkers and identified 127 …
Sleep/wake cycle alterations as a cause of neurodegenerative diseases: A Mendelian randomization study.
Cullell N, Cárcel-Márquez J, Gallego-Fábrega C, Muiño E, Llucià-Carol L, Lledós M, Amaut KEU, Krupinski J, Fernández-Cadenas I. Cullell N, et al. Neurobiol Aging. 2021 Oct;106:320.e1-320.e12. doi: 10.1016/j.neurobiolaging.2021.05.008. Epub 2021 May 24. Neurobiol Aging. 2021. PMID: 34130902 Free article.
Our aim was to determine whether there is a causal relationship between sleep and/or wake cycle patterns and ND (Parkinson's disease (PD) age at onset (AAO), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS)) using two-sample Mendelian …
Our aim was to determine whether there is a causal relationship between sleep and/or wake cycle patterns and ND (Parkinson's disease …
Genetically proxied lean mass and risk of Alzheimer's disease: mendelian randomisation study.
Daghlas I, Nassan M, Gill D. Daghlas I, et al. BMJ Med. 2023 Jun 29;2(1):e000354. doi: 10.1136/bmjmed-2022-000354. eCollection 2023. BMJ Med. 2023. PMID: 37564828 Free PMC article.
OBJECTIVE: To examine whether genetically proxied lean mass is associated with risk of Alzheimer's disease. DESIGN: Mendelian randomisation study. SETTING: The UK Biobank study and genome wide association study …
OBJECTIVE: To examine whether genetically proxied lean mass is associated with risk of Alzheimer's disease. DESI …
Entertainment activities and the risk of Alzheimer's disease: a Mendelian randomization analysis.
Lu T, Wang L, Zheng Y, Liu H, Liu J. Lu T, et al. Front Aging Neurosci. 2024 Jun 4;16:1419317. doi: 10.3389/fnagi.2024.1419317. eCollection 2024. Front Aging Neurosci. 2024. PMID: 38894851 Free PMC article.
BACKGROUND: Effective prevention is key to addressing the increasing prevalence and mortality of Alzheimer's disease. Assessing the causal relationship between modifiable entertainment activity factors and the risk of Alzheimer's disea …
BACKGROUND: Effective prevention is key to addressing the increasing prevalence and mortality of Alzheimer's disease. Assessin …
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