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Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome.
Andrews SJ, Fulton-Howard B, O'Reilly P, Marcora E, Goate AM; collaborators of the Alzheimer's Disease Genetics Consortium. Andrews SJ, et al. Ann Neurol. 2021 Jan;89(1):54-65. doi: 10.1002/ana.25918. Epub 2020 Oct 15. Ann Neurol. 2021. PMID: 32996171 Free PMC article.
METHODS: Polygenic risk scores (PRS) for the 22 risk factors were computed in 26,431 AD cases/controls and the association with AD was evaluated using logistic regression. Two-sample Mendelian randomization (MR) was used to infer the caus …
METHODS: Polygenic risk scores (PRS) for the 22 risk factors were computed in 26,431 AD cases/controls and the assoc
Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis.
Larsson SC, Traylor M, Malik R, Dichgans M, Burgess S, Markus HS; CoSTREAM Consortium, on behalf of the International Genomics of Alzheimer’s Project. Larsson SC, et al. BMJ. 2017 Dec 6;359:j5375. doi: 10.1136/bmj.j5375. BMJ. 2017. PMID: 29212772 Free PMC article.
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's disease. DESIGN: Mendelian
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, c …
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.
Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JR, Boehme KL, Walter S, Kauwe JS, Gibbons LE; Alzheimer’s Disease Genetics Consortium; GERAD1 Consortium; EPIC-InterAct Consortium, Larson EB, Powell JF, Langenberg C, Crane PK, Wareham NJ, Scott RA. Østergaard SD, et al. PLoS Med. 2015 Jun 16;12(6):e1001841; discussion e1001841. doi: 10.1371/journal.pmed.1001841. eCollection 2015 Jun. PLoS Med. 2015. PMID: 26079503 Free PMC article.
BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these …
BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are as
Sleep/wake cycle alterations as a cause of neurodegenerative diseases: A Mendelian randomization study.
Cullell N, Cárcel-Márquez J, Gallego-Fábrega C, Muiño E, Llucià-Carol L, Lledós M, Amaut KEU, Krupinski J, Fernández-Cadenas I. Cullell N, et al. Neurobiol Aging. 2021 Oct;106:320.e1-320.e12. doi: 10.1016/j.neurobiolaging.2021.05.008. Epub 2021 May 24. Neurobiol Aging. 2021. PMID: 34130902 Free article.
Our aim was to determine whether there is a causal relationship between sleep and/or wake cycle patterns and ND (Parkinson's disease (PD) age at onset (AAO), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS)) using two-sample …
Our aim was to determine whether there is a causal relationship between sleep and/or wake cycle patterns and ND (Parkinson's disea