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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 2
1991 5
1992 3
1993 1
1995 5
1996 4
1997 2
1998 1
1999 5
2000 2
2001 6
2002 5
2003 11
2004 15
2005 14
2006 19
2007 20
2008 19
2009 16
2010 13
2011 9
2012 20
2013 19
2014 34
2015 37
2016 28
2017 37
2018 38
2019 45
2020 5
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392 results
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Page 1
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Kunkle BW, et al. Nat Genet 2019. Among authors: Asthana S. PMID 30820047 Free PMC article.
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. ...
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk l …
Gut microbiome alterations in Alzheimer's disease.
Vogt NM, et al. Sci Rep 2017. Among authors: Asthana S. PMID 29051531 Free PMC article.
Alzheimer's disease (AD) is the most common form of dementia. However, the etiopathogenesis of this devastating disease is not fully understood. ...
Alzheimer's disease (AD) is the most common form of dementia. However, the etiopathogenesis of this devastating disease is not fully …
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Sims R, et al. Nat Genet 2017. Among authors: Asthana S. PMID 28714976 Free PMC article.
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. ...These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease....
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. ...The …
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease.
Vogt NM, et al. Alzheimers Res Ther 2018. Among authors: Asthana S. PMID 30579367 Free PMC article.
BACKGROUND: Trimethylamine N-oxide (TMAO), a small molecule produced by the metaorganismal metabolism of dietary choline, has been implicated in human disease pathogenesis, including known risk factors for Alzheimer's disease (AD), such as metabolic, cardiovascular, and cerebrovascular disease. METHODS: In this study, we tested whether TMAO is linked to AD by examining TMAO levels in cerebrospinal fluid (CSF) collected from a large sample (n = 410) of individuals with Alzheimer's clinical syndrome (n = 40), individuals with mild cognitive impairment (MCI) (n = 35), and cognitively-unimpaired individuals (n = 335). ...
BACKGROUND: Trimethylamine N-oxide (TMAO), a small molecule produced by the metaorganismal metabolism of dietary choline, has been implicate …
Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative.
Snyder HM, et al. Alzheimers Dement 2016 - Review. Among authors: Asthana S. PMID 27692800
More than 5 million Americans are living with Alzheimer's disease (AD) today, and nearly two-thirds of Americans with AD are women. ...The Alzheimer's Association convened an expert think tank to focus on the state of the science and level of evidence around gender and biological sex differences for AD, including the knowledge gaps and areas of science that need to be more fully addressed. ...
More than 5 million Americans are living with Alzheimer's disease (AD) today, and nearly two-thirds of Americans with AD are women. . …
Preface
DeKosky ST and Asthana S. Handb Clin Neurol 2019. PMID 31753160
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