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Cardiac contractility, central haemodynamics and blood pressure regulation during semistarvation.
Stokholm KH, Breum L, Astrup A. Stokholm KH, et al. Among authors: astrup a. Clin Physiol. 1991 Nov;11(6):513-23. doi: 10.1111/j.1475-097x.1991.tb00671.x. Clin Physiol. 1991. PMID: 1769186
Eight obese patients were studied before and after 2 weeks of treatment by a very-low-calorie diet (VLCD). Cardiac output and central blood volume (pulmonary blood volume and left atrial volume) were determined by indicator dilution (125I-albumin) and radionuclide angiocar …
Eight obese patients were studied before and after 2 weeks of treatment by a very-low-calorie diet (VLCD). Cardiac output and central …
Long-term effects of weight reduction on the severity of psoriasis in a cohort derived from a randomized trial: a prospective observational follow-up study.
Jensen P, Christensen R, Zachariae C, Geiker NR, Schaadt BK, Stender S, Hansen PR, Astrup A, Skov L. Jensen P, et al. Among authors: astrup a. Am J Clin Nutr. 2016 Aug;104(2):259-65. doi: 10.3945/ajcn.115.125849. Epub 2016 Jun 22. Am J Clin Nutr. 2016. PMID: 27334236 Clinical Trial.
DESIGN: We previously conducted a randomized trial (n = 60) involving patients with psoriasis who were allocated to a control group or a low-energy diet (LED) group. ...In total, 56 patients with psoriasis [mean ± SD body mass index (in kg/m(2)): 34.4 ± 5.3] …
DESIGN: We previously conducted a randomized trial (n = 60) involving patients with psoriasis who were allocated to a control …
New Nordic Diet-Induced Weight Loss Is Accompanied by Changes in Metabolism and AMPK Signaling in Adipose Tissue.
Fritzen AM, Lundsgaard AM, Jordy AB, Poulsen SK, Stender S, Pilegaard H, Astrup A, Larsen TM, Wojtaszewski JF, Richter EA, Kiens B. Fritzen AM, et al. Among authors: astrup a. J Clin Endocrinol Metab. 2015 Sep;100(9):3509-19. doi: 10.1210/jc.2015-2079. Epub 2015 Jun 30. J Clin Endocrinol Metab. 2015. PMID: 26126206
DESIGN: Volunteers consumed a New Nordic Diet (NND) or an Average Danish Diet for 26 weeks in a controlled, free-living setting. ...CONCLUSION: NND-induced metabolic improvements were accompanied by increased AMPK signaling in SCAT, suggesting a role of AMPK …
DESIGN: Volunteers consumed a New Nordic Diet (NND) or an Average Danish Diet for 26 weeks in a controlled, free-living settin …
Change in beta1-adrenergic receptor protein concentration in adipose tissue correlates with diet-induced weight loss.
Rasmussen M, Belza A, Almdal T, Toubro S, Bratholm P, Astrup A, Christensen NJ. Rasmussen M, et al. Among authors: astrup a. Clin Sci (Lond). 2005 Apr;108(4):323-9. doi: 10.1042/CS20040238. Clin Sci (Lond). 2005. PMID: 15574119
There was a 34% decrease in the beta(1)-adrenergic receptor mRNA level (0.92+/-0.09 compared with 0.61+/-0.06 amol/microg of DNA; P<0.002). ...In conclusion, the present study demonstrates a relationship between beta(1)-adrenergic receptor protein concentration i …
There was a 34% decrease in the beta(1)-adrenergic receptor mRNA level (0.92+/-0.09 compared with 0.61+/-0.06 amol/microg of DNA; P&l …
Comparison of resting energy expenditure measurements by ventilated canopy and by respiration chamber.
Kistorp CN, Toubro S, Astrup A, Svendsen OL. Kistorp CN, et al. Among authors: astrup a. Clin Physiol. 1999 Jul;19(4):344-7. doi: 10.1046/j.1365-2281.1999.00185.x. Clin Physiol. 1999. PMID: 10451796
Thirty-five healthy subjects of both sexes with a wide weight range (BMI 18-33.8 kg m-2) were measured on both systems. The linear regression equation was REEcanopy = 0.66 x REEresp.cham. + 61.1 (kJ h-1), and the corresponding SEE% was 8.6%. ...
Thirty-five healthy subjects of both sexes with a wide weight range (BMI 18-33.8 kg m-2) were measured on both systems. The linear re …
Normal levels of energy expenditure in patients with reported "low metabolism'.
Skov AR, Toubro S, Buemann B, Astrup A. Skov AR, et al. Among authors: astrup a. Clin Physiol. 1997 May;17(3):279-85. doi: 10.1111/j.1365-2281.1997.tb00007.x. Clin Physiol. 1997. PMID: 9171968
Twenty-four-hour energy expenditure (24-h EE), basal energy expenditure (BEE) and sleeping energy expenditure (SEE) were measured in a respiration chamber on a fixed activity programme. The patients consumed a diet containing 37 energy-per cent (E%) fat, 47 E …
Twenty-four-hour energy expenditure (24-h EE), basal energy expenditure (BEE) and sleeping energy expenditure (SEE) were measured in a
Long-term effects of fluoxetine on glycemic control in obese patients with non-insulin-dependent diabetes mellitus or glucose intolerance: influence on muscle glycogen synthase and insulin receptor kinase activity.
Breum L, Bjerre U, Bak JF, Jacobsen S, Astrup A. Breum L, et al. Among authors: astrup a. Metabolism. 1995 Dec;44(12):1570-6. doi: 10.1016/0026-0495(95)90077-2. Metabolism. 1995. PMID: 8786726 Clinical Trial.
Patients were assigned to receive either 60 mg F or placebo (P) daily in conjunction with a 5.0-MJ/d diet (> 50% carbohydrate). Both groups showed a significant weight loss, with a nadir after 6 months without group differences (mean +/- SD: F, 10.1 +/- 10 …
Patients were assigned to receive either 60 mg F or placebo (P) daily in conjunction with a 5.0-MJ/d diet (> 50% carbohydrate). Bo …
Insulin sensitivity in post-obese women.
Toubro S, Western P, Bülow J, MacDonald I, Raben A, Christensen NJ, Madsen J, Astrup A. Toubro S, et al. Among authors: astrup a. Clin Sci (Lond). 1994 Oct;87(4):407-13. doi: 10.1042/cs0870407. Clin Sci (Lond). 1994. PMID: 7834992
Therefore, insulin sensitivity was measured during a 2 h hyperinsulinaemia (100 m-units min-1 m-2) euglycaemic (4.5 mmol/l) glucose clamp combined with indirect calorimetry in nine weight-stable post-obese women and in nine matched control women preceded by 12 h fasting af …
Therefore, insulin sensitivity was measured during a 2 h hyperinsulinaemia (100 m-units min-1 m-2) euglycaemic (4.5 mmol/l) glucose c …
Secondary hyperparathyroidism of morbid obesity regresses during weight reduction.
Andersen T, McNair P, Hyldstrup L, Fogh-Andersen N, Nielsen TT, Astrup A, Transbøl I. Andersen T, et al. Among authors: astrup a. Metabolism. 1988 May;37(5):425-8. doi: 10.1016/0026-0495(88)90041-8. Metabolism. 1988. PMID: 3367788
In order to test the relation between obesity and the secondary hyperparathyroidism found in markedly overweight subjects, 24 morbidly obese patients were studied before and after a weight loss of 35.9 kg obtained by a nutritionally adequate, intermittent very-low-c …
In order to test the relation between obesity and the secondary hyperparathyroidism found in markedly overweight subjects, 24 morbidly obese …
Increased plasma fibronectin concentrations in obesity: normalization during weight loss.
Andersen T, Dejgaard A, Astrup A, Gluud C. Andersen T, et al. Among authors: astrup a. Acta Med Scand. 1987;222(3):275-9. doi: 10.1111/j.0954-6820.1987.tb10670.x. Acta Med Scand. 1987. PMID: 3321923
In 23 morbidly obese patients we investigated the influence of a large weight loss (30.6 kg, range 17.5-90.8) on the plasma fibronectin concentrations. ...We suggest the normalization to be mediated--at least in part--by a reduction of the insulin levels....
In 23 morbidly obese patients we investigated the influence of a large weight loss (30.6 kg, range 17.5-90.8) on the plasma fibronect …
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