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Polymorphic Variants of Human Protein l-Isoaspartyl Methyltransferase Affect Catalytic Activity, Aggregation, and Thermal Stability: IMPLICATIONS FOR THE ETIOLOGY OF NEUROLOGICAL DISORDERS AND COGNITIVE AGING.
Juang C, Chen B, Bru JL, Nguyen K, Huynh E, Momen M, Kim J, Aswad DW. Juang C, et al. Among authors: aswad dw. J Biol Chem. 2017 Mar 3;292(9):3656-3665. doi: 10.1074/jbc.M116.765222. Epub 2017 Jan 18. J Biol Chem. 2017. PMID: 28100787 Free PMC article.
Protein repair in the brain, proteomic analysis of endogenous substrates for protein L-isoaspartyl methyltransferase in mouse brain.
Zhu JX, Doyle HA, Mamula MJ, Aswad DW. Zhu JX, et al. Among authors: aswad dw. J Biol Chem. 2006 Nov 3;281(44):33802-13. doi: 10.1074/jbc.M606958200. Epub 2006 Sep 7. J Biol Chem. 2006. PMID: 16959769
Synapsin I is a major endogenous substrate for protein L-isoaspartyl methyltransferase in mammalian brain.
Reissner KJ, Paranandi MV, Luc TM, Doyle HA, Mamula MJ, Lowenson JD, Aswad DW. Reissner KJ, et al. Among authors: aswad dw. J Biol Chem. 2006 Mar 31;281(13):8389-98. doi: 10.1074/jbc.M510716200. Epub 2006 Jan 27. J Biol Chem. 2006. PMID: 16443604
Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B.
Young GW, Hoofring SA, Mamula MJ, Doyle HA, Bunick GJ, Hu Y, Aswad DW. Young GW, et al. Among authors: aswad dw. J Biol Chem. 2005 Jul 15;280(28):26094-8. doi: 10.1074/jbc.M503624200. Epub 2005 May 20. J Biol Chem. 2005. PMID: 15908425
Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent.
Qin Z, Kaufman RS, Khoury RN, Khoury MK, Aswad DW. Qin Z, et al. Among authors: aswad dw. PLoS One. 2013 Nov 5;8(11):e80758. doi: 10.1371/journal.pone.0080758. eCollection 2013. PLoS One. 2013. PMID: 24224061 Free PMC article.
The D-isoAsp-25 variant of histone H2B is highly enriched in active chromatin: potential role in the regulation of gene expression?
Qin Z, Zhu JX, Aswad DW. Qin Z, et al. Among authors: aswad dw. Amino Acids. 2016 Feb;48(2):599-603. doi: 10.1007/s00726-015-2140-9. Epub 2015 Dec 14. Amino Acids. 2016. PMID: 26666674 Free PMC article.
Isoaspartyl protein damage and repair in mouse retina.
Qin Z, Yang J, Klassen HJ, Aswad DW. Qin Z, et al. Among authors: aswad dw. Invest Ophthalmol Vis Sci. 2014 Mar 13;55(3):1572-9. doi: 10.1167/iovs.13-13668. Invest Ophthalmol Vis Sci. 2014. PMID: 24550364 Free PMC article.
Considerations in the identification of endogenous substrates for protein L-isoaspartyl methyltransferase: the case of synuclein.
Morrison GJ, Ganesan R, Qin Z, Aswad DW. Morrison GJ, et al. Among authors: aswad dw. PLoS One. 2012;7(8):e43288. doi: 10.1371/journal.pone.0043288. Epub 2012 Aug 14. PLoS One. 2012. PMID: 22905247 Free PMC article.
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