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Page 1
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase.
Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, Pandher K, Lapointe JM, Saha S, Roach ML, Carter D, Thomas NA, Durtschi BA, McNeish JD, Hambor JE, Jakobsson PJ, Carty TJ, Perez JR, Audoly LP. Trebino CE, et al. Among authors: audoly lp. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9044-9. doi: 10.1073/pnas.1332766100. Epub 2003 Jun 30. Proc Natl Acad Sci U S A. 2003. PMID: 12835414 Free PMC article.
Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction.
Degousee N, Fazel S, Angoulvant D, Stefanski E, Pawelzik SC, Korotkova M, Arab S, Liu P, Lindsay TF, Zhuo S, Butany J, Li RK, Audoly L, Schmidt R, Angioni C, Geisslinger G, Jakobsson PJ, Rubin BB. Degousee N, et al. Circulation. 2008 Apr 1;117(13):1701-10. doi: 10.1161/CIRCULATIONAHA.107.749739. Epub 2008 Mar 17. Circulation. 2008. PMID: 18347209
c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E2 synthase-1 mRNA regulates delayed microsomal prostaglandin E2 synthase-1 expression and prostaglandin E2 biosynthesis by cardiomyocytes.
Degousee N, Angoulvant D, Fazel S, Stefanski E, Saha S, Iliescu K, Lindsay TF, Fish JE, Marsden PA, Li RK, Audoly LP, Jakobsson PJ, Rubin BB. Degousee N, et al. Among authors: audoly lp. J Biol Chem. 2006 Jun 16;281(24):16443-52. doi: 10.1074/jbc.M602815200. Epub 2006 Apr 19. J Biol Chem. 2006. PMID: 16627484 Free article.
MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
Xu D, Rowland SE, Clark P, Giroux A, Côté B, Guiral S, Salem M, Ducharme Y, Friesen RW, Méthot N, Mancini J, Audoly L, Riendeau D. Xu D, et al. J Pharmacol Exp Ther. 2008 Sep;326(3):754-63. doi: 10.1124/jpet.108.138776. Epub 2008 Jun 4. J Pharmacol Exp Ther. 2008. PMID: 18524979
Prostaglandin E2 protects lower airways against bronchoconstriction.
Hartney JM, Coggins KG, Tilley SL, Jania LA, Lovgren AK, Audoly LP, Koller BH. Hartney JM, et al. Among authors: audoly lp. Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L105-13. doi: 10.1152/ajplung.00221.2005. Epub 2005 Aug 19. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16113047 Free article.
Role of microsomal prostaglandin E synthase 1 in the kidney.
Francois H, Facemire C, Kumar A, Audoly L, Koller B, Coffman T. Francois H, et al. J Am Soc Nephrol. 2007 May;18(5):1466-75. doi: 10.1681/ASN.2006040343. Epub 2007 Apr 18. J Am Soc Nephrol. 2007. PMID: 17442791
55 results