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Essential role of Mash-2 in extraembryonic development.
Guillemot F, Nagy A, Auerbach A, Rossant J, Joyner AL. Guillemot F, et al. Among authors: auerbach a. Nature. 1994 Sep 22;371(6495):333-6. doi: 10.1038/371333a0. Nature. 1994. PMID: 8090202
Lineage-specific transcription factors may be important in lineage specification, and the product of the Mash-2 gene fulfils the criteria for such a factor. ...Mash-2 is the first transcription factor shown to play a critical part in the development of the mammalian …
Lineage-specific transcription factors may be important in lineage specification, and the product of the Mash-2 gene fulfils the criteria fo …
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons.
Guillemot F, Lo LC, Johnson JE, Auerbach A, Anderson DJ, Joyner AL. Guillemot F, et al. Among authors: auerbach a. Cell. 1993 Nov 5;75(3):463-76. doi: 10.1016/0092-8674(93)90381-y. Cell. 1993. PMID: 8221886
The mouse Mash-1 gene, like its Drosophila homologs of the achaete-scute complex (AS-C), encodes a transcription factor expressed in neural precursors. We created a null allele of this gene by homologous recombination in embryonic stem cells. Mice homozygous for the …
The mouse Mash-1 gene, like its Drosophila homologs of the achaete-scute complex (AS-C), encodes a transcription factor expressed in …
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.
Dumont DJ, Gradwohl G, Fong GH, Puri MC, Gertsenstein M, Auerbach A, Breitman ML. Dumont DJ, et al. Among authors: auerbach a. Genes Dev. 1994 Aug 15;8(16):1897-909. doi: 10.1101/gad.8.16.1897. Genes Dev. 1994. PMID: 7958865
First, we constructed transgenic mice expressing a dominant-negative form of the Tek receptor. Second, we created a null allele of the tek gene by homologous recombination in embryonic stem (ES) cells. Transgenic mice expressing dominant-negative alleles of Tek or h …
First, we constructed transgenic mice expressing a dominant-negative form of the Tek receptor. Second, we created a null allel …
The gene trap approach in embryonic stem cells: the potential for genetic screens in mice.
Joyner AL, Auerbach A, Skarnes WC. Joyner AL, et al. Among authors: auerbach a. Ciba Found Symp. 1992;165:277-88; discussion 288-97. doi: 10.1002/9780470514221.ch16. Ciba Found Symp. 1992. PMID: 1516474 Review.
The results indicate that a large screen of gene trap cell lines on the basis of embryonic lacZ expression is feasible and should provide a new source of genes, mouse mutants and mouse strains that express lacZ in particular domains and lineages. The gene trap appro …
The results indicate that a large screen of gene trap cell lines on the basis of embryonic lacZ expression is feasible and should pro …
A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice.
Wurst W, Rossant J, Prideaux V, Kownacka M, Joyner A, Hill DP, Guillemot F, Gasca S, Cado D, Auerbach A, et al. Wurst W, et al. Among authors: auerbach a. Genetics. 1995 Feb;139(2):889-99. Genetics. 1995. PMID: 7713439 Free PMC article.
We have used a gene-trap vector and mouse embryonic stem (ES) cells to screen for insertional mutations in genes developmentally regulated at 8.5 days of embryogenesis (dpc). ...Thus, a large proportion of the genes that are expressed in ES cells are either temporal …
We have used a gene-trap vector and mouse embryonic stem (ES) cells to screen for insertional mutations in genes developmentally regu …
Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia.
Chen M, Tomkins DJ, Auerbach W, McKerlie C, Youssoufian H, Liu L, Gan O, Carreau M, Auerbach A, Groves T, Guidos CJ, Freedman MH, Cross J, Percy DH, Dick JE, Joyner AL, Buchwald M. Chen M, et al. Among authors: auerbach w, auerbach a. Nat Genet. 1996 Apr;12(4):448-51. doi: 10.1038/ng0496-448. Nat Genet. 1996. PMID: 8630504
Homozygous male and female mice also had compromised gametogenesis, leading to markedly impaired fertility, a characteristic of FA patients. ...
Homozygous male and female mice also had compromised gametogenesis, leading to markedly impaired fertility, a characteristic of FA pa …
A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung.
Moens CB, Auerbach AB, Conlon RA, Joyner AL, Rossant J. Moens CB, et al. Among authors: auerbach ab. Genes Dev. 1992 May;6(5):691-704. doi: 10.1101/gad.6.5.691. Genes Dev. 1992. PMID: 1577267
We have generated a leaky mutation in N-myc by gene targeting in embryonic stem cells. In this allele, the neo(r) gene was inserted into the first intron of N-myc, in such a way that alternative splicing around this insertion could result in the generation of a
We have generated a leaky mutation in N-myc by gene targeting in embryonic stem cells. In this allele, the neo(r) gene was inserted i …
Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2.
Hanks M, Wurst W, Anson-Cartwright L, Auerbach AB, Joyner AL. Hanks M, et al. Among authors: auerbach ab. Science. 1995 Aug 4;269(5224):679-82. doi: 10.1126/science.7624797. Science. 1995. PMID: 7624797
The related mouse Engrailed genes En-1 and En-2 are expressed from the one- and approximately five-somite stages, respectively, in a similar presumptive mid-hindbrain domain. ...En-1 mutant mice die at birth with a large mid-hindbrain deletion, whereas En-2 mutants …
The related mouse Engrailed genes En-1 and En-2 are expressed from the one- and approximately five-somite stages, respectively, in a
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.
Scrocchi LA, Brown TJ, MaClusky N, Brubaker PL, Auerbach AB, Joyner AL, Drucker DJ. Scrocchi LA, et al. Among authors: auerbach ab. Nat Med. 1996 Nov;2(11):1254-8. doi: 10.1038/nm1196-1254. Nat Med. 1996. PMID: 8898756
To ascertain the relative physiological importance of GLP1 as a regulator of feeding behavior and insulin secretion, we have generated mice with a targeted disruption of the GLP1 receptor gene (GLP1R). ...These observations demonstrate that GLP1 plays a centr …
To ascertain the relative physiological importance of GLP1 as a regulator of feeding behavior and insulin secretion, we have generate …
Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum.
Wurst W, Auerbach AB, Joyner AL. Wurst W, et al. Among authors: auerbach ab. Development. 1994 Jul;120(7):2065-75. Development. 1994. PMID: 7925010
To address the function of En-1 during embryogenesis, we have generated mice homozygous for a targeted deletion of the En-1 homeobox. ...The results of these studies suggest a cell autonomous role for En-1 in generation and/or survival of mid-hindbrain precursor cel …
To address the function of En-1 during embryogenesis, we have generated mice homozygous for a targeted deletion of the En-1 homeobox. …
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