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Soft tissue sarcomas with complex genomic profiles.
Guillou L, Aurias A. Guillou L, et al. Among authors: aurias a. Virchows Arch. 2010 Feb;456(2):201-17. doi: 10.1007/s00428-009-0853-4. Virchows Arch. 2010. PMID: 20217954 Review.
., gain of 5p13-p15) that seem to play a significant role in tumor progression and/or metastatic dissemination. In this paper, we review the cytogenetic, molecular genetic, and clinicopathologic characteristics of the most common STS displaying complex genomic profiles. .. …
., gain of 5p13-p15) that seem to play a significant role in tumor progression and/or metastatic dissemination. In this paper, we rev …
Smooth muscle differentiation identifies two classes of poorly differentiated pleomorphic sarcomas with distinct outcome.
Pérot G, Mendiboure J, Brouste V, Velasco V, Terrier P, Bonvalot S, Guillou L, Ranchère-Vince D, Aurias A, Coindre JM, Chibon F. Pérot G, et al. Among authors: aurias a. Mod Pathol. 2014 Jun;27(6):840-50. doi: 10.1038/modpathol.2013.205. Epub 2013 Nov 29. Mod Pathol. 2014. PMID: 24287457 Free article.
MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone.
Dujardin F, Binh MB, Bouvier C, Gomez-Brouchet A, Larousserie F, Muret Ad, Louis-Brennetot C, Aurias A, Coindre JM, Guillou L, Pedeutour F, Duval H, Collin C, de Pinieux G. Dujardin F, et al. Among authors: aurias a. Mod Pathol. 2011 May;24(5):624-37. doi: 10.1038/modpathol.2010.229. Epub 2011 Feb 18. Mod Pathol. 2011. PMID: 21336260 Free article.
Well-differentiated and dedifferentiated liposarcomas.
Coindre JM, Pédeutour F, Aurias A. Coindre JM, et al. Among authors: aurias a. Virchows Arch. 2010 Feb;456(2):167-79. doi: 10.1007/s00428-009-0815-x. Epub 2009 Aug 18. Virchows Arch. 2010. PMID: 19688222 Review.
Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving MDM2 gene. ...
Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genet …
From PTEN loss of expression to RICTOR role in smooth muscle differentiation: complex involvement of the mTOR pathway in leiomyosarcomas and pleomorphic sarcomas.
Gibault L, Ferreira C, Pérot G, Audebourg A, Chibon F, Bonnin S, Lagarde P, Vacher-Lavenu MC, Terrier P, Coindre JM, Aurias A. Gibault L, et al. Among authors: aurias a. Mod Pathol. 2012 Feb;25(2):197-211. doi: 10.1038/modpathol.2011.163. Epub 2011 Nov 11. Mod Pathol. 2012. PMID: 22080063 Free article.
Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity.
Chibon F, Lagarde P, Salas S, Pérot G, Brouste V, Tirode F, Lucchesi C, de Reynies A, Kauffmann A, Bui B, Terrier P, Bonvalot S, Le Cesne A, Vince-Ranchère D, Blay JY, Collin F, Guillou L, Leroux A, Coindre JM, Aurias A. Chibon F, et al. Among authors: aurias a. Nat Med. 2010 Jul;16(7):781-7. doi: 10.1038/nm.2174. Epub 2010 Jun 27. Nat Med. 2010. PMID: 20581836
To improve patient grading, we performed genomic and expression profiling in a training set of 183 sarcomas and established a prognostic gene expression signature, complexity index in sarcomas (CINSARC), composed of 67 genes related to mitosis and chromosome managem …
To improve patient grading, we performed genomic and expression profiling in a training set of 183 sarcomas and established a
Gene Expression Profiling of Desmoid Tumors by cDNA Microarrays and Correlation with Progression-Free Survival.
Salas S, Brulard C, Terrier P, Ranchere-Vince D, Neuville A, Guillou L, Lae M, Leroux A, Verola O, Jean-Emmanuel K, Bonvalot S, Blay JY, Le Cesne A, Aurias A, Coindre JM, Chibon F. Salas S, et al. Among authors: aurias a. Clin Cancer Res. 2015 Sep 15;21(18):4194-200. doi: 10.1158/1078-0432.CCR-14-2910. Epub 2015 Apr 15. Clin Cancer Res. 2015. PMID: 25878329 Free article.
YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas.
Hélias-Rodzewicz Z, Pérot G, Chibon F, Ferreira C, Lagarde P, Terrier P, Coindre JM, Aurias A. Hélias-Rodzewicz Z, et al. Among authors: aurias a. Genes Chromosomes Cancer. 2010 Dec;49(12):1161-71. doi: 10.1002/gcc.20825. Genes Chromosomes Cancer. 2010. PMID: 20842732
In a series of 404 adult soft tissue sarcomas, analyzed by array-CGH, we have observed in approximately 10% of them a genomic amplification of either chromosome bands 11q22 or 3p12. ...Welch test analyses of transcriptome data demonstrate that tumors with amplicons …
In a series of 404 adult soft tissue sarcomas, analyzed by array-CGH, we have observed in approximately 10% of them a genomic …
Molecular cytogenetic characterization of a metastatic lung sarcomatoid carcinoma: 9p23 neocentromere and 9p23-p24 amplification including JAK2 and JMJD2C.
Italiano A, Attias R, Aurias A, Pérot G, Burel-Vandenbos F, Otto J, Venissac N, Pedeutour F. Italiano A, et al. Among authors: aurias a. Cancer Genet Cytogenet. 2006 Jun;167(2):122-30. doi: 10.1016/j.cancergencyto.2006.01.004. Cancer Genet Cytogenet. 2006. PMID: 16737911
Sarcomatoid carcinoma of the lung (LSC) is a rare lung cancer characterized by an admixture of carcinoma and sarcoma components. ...Here, we report on the first molecular cytogenetic characterization of a metastatic LSC. Cytogenetic and multicolor fluorescence in si …
Sarcomatoid carcinoma of the lung (LSC) is a rare lung cancer characterized by an admixture of carcinoma and sarcoma components. ...H …
Overlapping 3q28 amplifications in the COMA cell line and undifferentiated primary sarcoma.
Hussenet T, Mallem N, Redon R, Jost B, Aurias A, du Manoir S. Hussenet T, et al. Among authors: aurias a. Cancer Genet Cytogenet. 2006 Sep;169(2):102-13. doi: 10.1016/j.cancergencyto.2006.03.009. Cancer Genet Cytogenet. 2006. PMID: 16938567
The COMA cell line established from a sarcoma contains DMs, some of them composed of material of the long arm of chromosome 3. ...Expression levels of all transcripts were almost similar in both cell lines, except for two ESTs (AI338598 and BX118304) showing a 20-fo …
The COMA cell line established from a sarcoma contains DMs, some of them composed of material of the long arm of chromosome 3. ...Exp …
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