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Salicylate improves macrophage cholesterol homeostasis via activation of Ampk.
Fullerton MD, Ford RJ, McGregor CP, LeBlond ND, Snider SA, Stypa SA, Day EA, Lhoták Š, Schertzer JD, Austin RC, Kemp BE, Steinberg GR. Fullerton MD, et al. Among authors: austin rc. J Lipid Res. 2015 May;56(5):1025-33. doi: 10.1194/jlr.M058875. Epub 2015 Mar 15. J Lipid Res. 2015. PMID: 25773887 Free PMC article.
Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.
Al-Hashimi AA, Lebeau P, Majeed F, Polena E, Lhotak Š, Collins CAF, Pinthus JH, Gonzalez-Gronow M, Hoogenes J, Pizzo SV, Crowther M, Kapoor A, Rak J, Gyulay G, D'Angelo S, Marchiò S, Pasqualini R, Arap W, Shayegan B, Austin RC. Al-Hashimi AA, et al. Among authors: austin rc. J Biol Chem. 2017 Dec 22;292(51):21180-21192. doi: 10.1074/jbc.M117.799908. Epub 2017 Oct 24. J Biol Chem. 2017. PMID: 29066620 Free PMC article.
Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering.
Yu P, Xiong T, Tenedero CB, Lebeau P, Ni R, MacDonald ME, Gross PL, Austin RC, Trigatti BL. Yu P, et al. Among authors: austin rc. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):26-39. doi: 10.1161/ATVBAHA.117.305140. Epub 2017 Nov 21. Arterioscler Thromb Vasc Biol. 2018. PMID: 29162602 Free PMC article.
Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained.
Lebeau P, Platko K, Al-Hashimi AA, Byun JH, Lhoták Š, Holzapfel N, Gyulay G, Igdoura SA, Cool DR, Trigatti B, Seidah NG, Austin RC. Lebeau P, et al. Among authors: austin rc. J Biol Chem. 2018 May 11;293(19):7329-7343. doi: 10.1074/jbc.RA117.001049. Epub 2018 Mar 28. J Biol Chem. 2018. PMID: 29593095 Free PMC article.
162 results