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Immune Response Modifications in the Genetic Forms of Parkinson's Disease: What Do We Know?
Magistrelli L, Contaldi E, Vignaroli F, Gallo S, Colombatto F, Cantello R, Comi C. Magistrelli L, et al. Int J Mol Sci. 2022 Mar 23;23(7):3476. doi: 10.3390/ijms23073476. Int J Mol Sci. 2022. PMID: 35408836 Free PMC article. Review.
Parkinson's disease (PD) is a common neurodegenerative disease characterized by loss of dopaminergic neurons in the pars compacta of the midbrain substantia nigra. ...Nonetheless, recent data show that immune system hyperactivation with concomitant production
Parkinson's disease (PD) is a common neurodegenerative disease characterized by loss of dopaminergic neurons in the par
Mitochondrial quality control turns out to be the principal suspect in parkin and PINK1-related autosomal recessive Parkinson's disease.
Corti O, Brice A. Corti O, et al. Curr Opin Neurobiol. 2013 Feb;23(1):100-8. doi: 10.1016/j.conb.2012.11.002. Epub 2012 Nov 30. Curr Opin Neurobiol. 2013. PMID: 23206589 Free article. Review.
Mitochondrial dysfunction has long been suspected to play a key role in neurodegeneration in Parkinson's disease. PINK1 and Parkin, the products of two genes responsible for autosomal recessive Parkinsonian syndromes with early onset, act …
Mitochondrial dysfunction has long been suspected to play a key role in neurodegeneration in Parkinson's disease. PINK1 and Pa …
Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond.
Bayne AN, Trempe JF. Bayne AN, et al. Cell Mol Life Sci. 2019 Dec;76(23):4589-4611. doi: 10.1007/s00018-019-03203-4. Epub 2019 Jun 28. Cell Mol Life Sci. 2019. PMID: 31254044 Free PMC article. Review.
Parkinson's disease (PD) is a degenerative movement disorder resulting from the loss of specific neuron types in the midbrain. ...These findings are now vindicated by the characterization of more than 20 genes implicated in rare familial forms of the disease.
Parkinson's disease (PD) is a degenerative movement disorder resulting from the loss of specific neuron types in the midbrain.
[The genetics of Parkinson syndrome].
Klein C. Klein C. Praxis (Bern 1994). 2001 Jun 7;90(23):1015-23. Praxis (Bern 1994). 2001. PMID: 11447721 Review. German.
Mutations in the parkins gene (PARK2), causing autosomal recessive early-onset parkinsonism, are much more common and therefore of clinical relevance. ...All three parkinson genes identified thus far imply the involvement of the ubiquitin pathwa …
Mutations in the parkins gene (PARK2), causing autosomal recessive early-onset parkinsonism, are much more commo …