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Pathogenesis of DJ-1/PARK7-Mediated Parkinson's Disease.
Skou LD, Johansen SK, Okarmus J, Meyer M. Skou LD, et al. Cells. 2024 Feb 6;13(4):296. doi: 10.3390/cells13040296. Cells. 2024. PMID: 38391909 Free PMC article. Review.
Mutations in the PD-associated gene PARK7 alter the structure and function of the encoded protein DJ-1, and the resulting autosomal recessively inherited disease increases the risk of developing PD. DJ-1 was first discovered in 1997 as an oncogene and was ass …
Mutations in the PD-associated gene PARK7 alter the structure and function of the encoded protein DJ-1, and the resulting autosomal
PARK7/DJ-1 in microglia: implications in Parkinson's disease and relevance as a therapeutic target.
Lind-Holm Mogensen F, Scafidi A, Poli A, Michelucci A. Lind-Holm Mogensen F, et al. J Neuroinflammation. 2023 Apr 18;20(1):95. doi: 10.1186/s12974-023-02776-z. J Neuroinflammation. 2023. PMID: 37072827 Free PMC article. Review.
Microglia are the immune effector cells of the brain playing critical roles in immune surveillance and neuroprotection in healthy conditions, while they can sustain neuroinflammatory and neurotoxic processes in neurodegenerative diseases, including Parkinson's disease
Microglia are the immune effector cells of the brain playing critical roles in immune surveillance and neuroprotection in healthy conditions …
Cancer and Parkinson's disease: the odd couple.
Gao X, Ning Y. Gao X, et al. Drugs Today (Barc). 2011 Mar;47(3):215-22. doi: 10.1358/dot.2011.47.3.1519657. Drugs Today (Barc). 2011. PMID: 21494699 Review.
Epidemiological studies have consistently shown that individuals with Parkinson's disease (PD) are less likely to develop nonmelanoma cancers and vice versa. ...Different hypotheses have been put forward, including shared environmental/lifestyle factors (e.g., smoki …
Epidemiological studies have consistently shown that individuals with Parkinson's disease (PD) are less likely to develop nonm …
DJ-1/PARK7: A New Therapeutic Target for Neurodegenerative Disorders.
Hijioka M, Inden M, Yanagisawa D, Kitamura Y. Hijioka M, et al. Biol Pharm Bull. 2017;40(5):548-552. doi: 10.1248/bpb.b16-01006. Biol Pharm Bull. 2017. PMID: 28458339 Free article. Review.
DJ-1, encoded in a causative gene of familial Parkinson's disease (PARK7), has multiple functions: it works as an antioxidant, in transcriptional regulation, as a molecular chaperone and in protein degradation. ...The administration of recombinant wild-type DJ-1 pro …
DJ-1, encoded in a causative gene of familial Parkinson's disease (PARK7), has multiple functions: it works as an antioxidant, …
Mendelian forms of Parkinson's disease.
Gasser T. Gasser T. Biochim Biophys Acta. 2009 Jul;1792(7):587-96. doi: 10.1016/j.bbadis.2008.12.007. Epub 2009 Jan 6. Biochim Biophys Acta. 2009. PMID: 19168133 Free article. Review.
Over the last few years, genetic findings have changed our views on Parkinson's disease (PD), as mutations in a growing number of genes are found to cause monogenic forms of the disorder. ...Mutations in the gene for leucine-rich repeat kinase 2 (LRRK2) have recentl …
Over the last few years, genetic findings have changed our views on Parkinson's disease (PD), as mutations in a growing number …
DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application.
Huang M, Chen S. Huang M, et al. Prog Neurobiol. 2021 Sep;204:102114. doi: 10.1016/j.pneurobio.2021.102114. Epub 2021 Jun 24. Prog Neurobiol. 2021. PMID: 34174373 Free article. Review.
The mechanisms of NDs are still not fully understood. The study of genetic defects and disease-related proteins offers us a window into the mystery of it, and the extension of knowledge indicates that different NDs share similar features, mechanisms, and even genetic or pr …
The mechanisms of NDs are still not fully understood. The study of genetic defects and disease-related proteins offers us a window in …
Immune Response Modifications in the Genetic Forms of Parkinson's Disease: What Do We Know?
Magistrelli L, Contaldi E, Vignaroli F, Gallo S, Colombatto F, Cantello R, Comi C. Magistrelli L, et al. Int J Mol Sci. 2022 Mar 23;23(7):3476. doi: 10.3390/ijms23073476. Int J Mol Sci. 2022. PMID: 35408836 Free PMC article. Review.
Parkinson's disease (PD) is a common neurodegenerative disease characterized by loss of dopaminergic neurons in the pars compacta of the midbrain substantia nigra. ...Nonetheless, recent data show that immune system hyperactivation with concomitant production
Parkinson's disease (PD) is a common neurodegenerative disease characterized by loss of dopaminergic neurons in the par
DJ-1: a newcomer in Parkinson's disease pathology.
da Costa CA. da Costa CA. Curr Mol Med. 2007 Nov;7(7):650-7. doi: 10.2174/156652407782564426. Curr Mol Med. 2007. PMID: 18045143 Review.
Parkinson's disease (PD) is a movement disorder of high prevalence in the elderly. ...To date six familial PD-associated proteins have been identified so far. Some of them are implicated in the development of either autosomal dominant (alpha-synuclein and LRR
Parkinson's disease (PD) is a movement disorder of high prevalence in the elderly. ...To date six familial PD-associated prote
The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research.
Sun ME, Zheng Q. Sun ME, et al. Int J Mol Sci. 2023 Apr 18;24(8):7409. doi: 10.3390/ijms24087409. Int J Mol Sci. 2023. PMID: 37108572 Free PMC article. Review.
., epigenetic regulations) and make it a promising therapeutic target for diverse diseases (especially cancer and Parkinson's disease). Due to its nature as a Swiss army knife enzyme with various functions, DJ-1 has attracted a large amount of research interest, fro …
., epigenetic regulations) and make it a promising therapeutic target for diverse diseases (especially cancer and Parkinson's dise
Hereditary Parkinsonism-Associated Genetic Variations in PARK9 Locus Lead to Functional Impairment of ATPase Type 13A2.
Park JS, Sue CM. Park JS, et al. Curr Protein Pept Sci. 2017;18(7):725-732. doi: 10.2174/1389203717666160311121534. Curr Protein Pept Sci. 2017. PMID: 26965689 Review.
Kufor-Rakeb syndrome (KRS) is an autosomal recessive form of Parkinson's disease (PD) with juvenile onset of parkinsonism, often accompanied by extra clinical features such as supranuclear gaze palsy, dementia and generalised brain atrophy. ...Until no …
Kufor-Rakeb syndrome (KRS) is an autosomal recessive form of Parkinson's disease (PD) with juvenile onset of par …