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6,936 results

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Page 1
Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice.
Jurcak NR, Rucki AA, Muth S, Thompson E, Sharma R, Ding D, Zhu Q, Eshleman JR, Anders RA, Jaffee EM, Fujiwara K, Zheng L. Jurcak NR, et al. Gastroenterology. 2019 Sep;157(3):838-850.e6. doi: 10.1053/j.gastro.2019.05.065. Epub 2019 Jun 1. Gastroenterology. 2019. PMID: 31163177 Free PMC article.
Annexin A2 (ANXA2) regulates secretion of SEMA3D, an axon guidance molecule, which binds and activates the receptor PLXND1 to promote PDA invasion and metastasis. ...Increased levels of SEMA3D and PLXND1 in human PDA specimens associated with PNI. Strategies to disr …
Annexin A2 (ANXA2) regulates secretion of SEMA3D, an axon guidance molecule, which binds and activates the receptor PLXND1 to …
Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC.
Lupo F, Pezzini F, Pasini D, Fiorini E, Adamo A, Veghini L, Bevere M, Frusteri C, Delfino P, D'agosto S, Andreani S, Piro G, Malinova A, Wang T, De Sanctis F, Lawlor RT, Hwang CI, Carbone C, Amelio I, Bailey P, Bronte V, Tuveson D, Scarpa A, Ugel S, Corbo V. Lupo F, et al. Gut. 2024 Jul 11;73(8):1321-1335. doi: 10.1136/gutjnl-2023-329807. Gut. 2024. PMID: 38670629 Free PMC article.
OBJECTIVE: The dysregulation of the axon guidance pathway is common in pancreatic ductal adenocarcinoma (PDAC), yet our understanding of its biological relevance is limited. Here, we investigated the functional role of the axon guidance cue SEMA …
OBJECTIVE: The dysregulation of the axon guidance pathway is common in pancreatic ductal adenocarcinoma (PDAC), yet our …
Neurogenesis, neuronal migration, and axon guidance.
Accogli A, Addour-Boudrahem N, Srour M. Accogli A, et al. Handb Clin Neurol. 2020;173:25-42. doi: 10.1016/B978-0-444-64150-2.00004-6. Handb Clin Neurol. 2020. PMID: 32958178 Review.
In this chapter, we review the current knowledge regarding the main developmental processes and signaling mechanisms of (i) neurogenesis, (ii) neuronal migration, and (iii) axon guidance. We discuss mechanisms related to neural stem cells proliferation, migration, t …
In this chapter, we review the current knowledge regarding the main developmental processes and signaling mechanisms of (i) neurogenesis, (i …
Efferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/MERTK signaling following brain injury.
Soliman E, Leonard J, Basso EKG, Gershenson I, Ju J, Mills J, de Jager C, Kaloss AM, Elhassanny M, Pereira D, Chen M, Wang X, Theus MH. Soliman E, et al. J Neuroinflammation. 2023 Nov 9;20(1):256. doi: 10.1186/s12974-023-02940-5. J Neuroinflammation. 2023. PMID: 37941008 Free PMC article.
METHODS: We used GFP bone marrow chimeric knockout (KO) mice to demonstrate that the axon guidance molecule EphA4 receptor tyrosine kinase is involved in suppressing MERTK in the brain to restrict efferocytosis of resident microglia and peripheral-derived monocyte/m …
METHODS: We used GFP bone marrow chimeric knockout (KO) mice to demonstrate that the axon guidance molecule EphA4 receptor tyr …
Midline assembloids reveal regulators of human axon guidance.
Onesto MM, Amin ND, Pan C, Chen X, Kim JI, Reis N, Kanton S, Valencia AM, Hudacova Z, McQueen JP, Tessier-Lavigne M, Pașca SP. Onesto MM, et al. Science. 2025 Jul 17;389(6757):282-289. doi: 10.1126/science.adq7934. Epub 2025 Jul 17. Science. 2025. PMID: 40674484
Organizers orchestrate cell patterning and axon guidance in the developing nervous system. Although nonhuman models have led to fundamental discoveries about floor plate (FP)-mediated midline organization, an experimental model of the human FP would enable insights …
Organizers orchestrate cell patterning and axon guidance in the developing nervous system. Although nonhuman models have led t …
Axon Guidance Molecules and Pain.
Damo E, Simonetti M. Damo E, et al. Cells. 2022 Oct 6;11(19):3143. doi: 10.3390/cells11193143. Cells. 2022. PMID: 36231105 Free PMC article. Review.
Inter-growth cone communication mediated by planar cell polarity pathway in axon guidance.
Zou Y. Zou Y. Dev Biol. 2022 Oct;490:50-52. doi: 10.1016/j.ydbio.2022.06.016. Epub 2022 Jul 1. Dev Biol. 2022. PMID: 35788000 Free article.
It is well known that axonal growth cones recognize cell surface guidance cues on axons and either grow along the axons or away from the axons. However, it is less well understood whether and how the growth cones communicate with each other and, if so, what do these intera …
It is well known that axonal growth cones recognize cell surface guidance cues on axons and either grow along the axons or away from …
Protocadherin 19 regulates axon guidance in the developing Xenopus retinotectal pathway.
Jung J, Park J, Park S, Kim CH, Jung H. Jung J, et al. Mol Brain. 2024 Aug 22;17(1):58. doi: 10.1186/s13041-024-01130-5. Mol Brain. 2024. PMID: 39175067 Free PMC article.
Here, we tested whether Pcdh19 has a regulatory role in axon guidance using the developing Xenopus retinotectal system. We performed targeted microinjections of a translation blocking antisense morpholino oligonucleotide to knock down the expression of Pcdh19 select …
Here, we tested whether Pcdh19 has a regulatory role in axon guidance using the developing Xenopus retinotectal system. We per …
6,936 results