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The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis.
Yabuta N, Mukai S, Okada N, Aylon Y, Nojima H. Yabuta N, et al. Among authors: aylon y. Cell Cycle. 2011 Aug 15;10(16):2724-36. doi: 10.4161/cc.10.16.16873. Epub 2011 Aug 15. Cell Cycle. 2011. PMID: 21822051
Lats2 is critical for the pluripotency and proper differentiation of stem cells.
Aylon Y, Sarver A, Tovy A, Ainbinder E, Oren M. Aylon Y, et al. Cell Death Differ. 2014 Apr;21(4):624-33. doi: 10.1038/cdd.2013.188. Epub 2014 Jan 10. Cell Death Differ. 2014. PMID: 24413153 Free PMC article.
Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation.
Aylon Y, Yabuta N, Besserglick H, Buganim Y, Rotter V, Nojima H, Oren M. Aylon Y, et al. Oncogene. 2009 Dec 17;28(50):4469-79. doi: 10.1038/onc.2009.270. Epub 2009 Oct 26. Oncogene. 2009. PMID: 19855428 Free PMC article.
Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis.
Suzuki H, Yabuta N, Okada N, Torigata K, Aylon Y, Oren M, Nojima H. Suzuki H, et al. Among authors: aylon y. J Cell Sci. 2013 Oct 1;126(Pt 19):4358-68. doi: 10.1242/jcs.125815. Epub 2013 Jul 25. J Cell Sci. 2013. PMID: 23886938
A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage.
Okada N, Yabuta N, Suzuki H, Aylon Y, Oren M, Nojima H. Okada N, et al. Among authors: aylon y. J Cell Sci. 2011 Jan 1;124(Pt 1):57-67. doi: 10.1242/jcs.072918. Epub 2010 Nov 30. J Cell Sci. 2011. PMID: 21118956
Cell cycle-dependent regulation of double-strand break repair: a role for the CDK.
Aylon Y, Kupiec M. Aylon Y, et al. Cell Cycle. 2005 Feb;4(2):259-61. Epub 2005 Feb 7. Cell Cycle. 2005. PMID: 15655342
Tumor Suppression by p53: Bring in the Hippo!
Aylon Y, Oren M. Aylon Y, et al. Cancer Cell. 2017 Oct 9;32(4):397-399. doi: 10.1016/j.ccell.2017.09.010. Cancer Cell. 2017. PMID: 29017051 Free article.
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.
Furth N, Aylon Y. Furth N, et al. Among authors: aylon y. Cell Death Differ. 2017 Sep;24(9):1488-1501. doi: 10.1038/cdd.2017.99. Epub 2017 Jun 23. Cell Death Differ. 2017. PMID: 28644436 Free PMC article. Review.
The Hippo pathway, p53 and cholesterol.
Aylon Y, Oren M. Aylon Y, et al. Cell Cycle. 2016 Sep;15(17):2248-55. doi: 10.1080/15384101.2016.1207840. Epub 2016 Jul 15. Cell Cycle. 2016. PMID: 27419353 Free PMC article. Review.
The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.
Aylon Y, Gershoni A, Rotkopf R, Biton IE, Porat Z, Koh AP, Sun X, Lee Y, Fiel MI, Hoshida Y, Friedman SL, Johnson RL, Oren M. Aylon Y, et al. Genes Dev. 2016 Apr 1;30(7):786-97. doi: 10.1101/gad.274167.115. Epub 2016 Mar 24. Genes Dev. 2016. PMID: 27013235 Free PMC article.
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