Ayoub AT - Search Results

1

Anesthetics act in quantum channels in brain microtubules to prevent consciousness.

Craddock TJ, Hameroff SR, Ayoub AT, Klobukowski M, Tuszynski JA. Craddock TJ, et al. Among authors: ayoub at. Curr Top Med Chem. 2015;15(6):523-33. doi: 10.2174/1568026615666150225104543. Curr Top Med Chem. 2015. PMID: 25714379

2

Antitumor Activity of Lankacidin Group Antibiotics Is Due to Microtubule Stabilization via a Paclitaxel-like Mechanism.

Ayoub AT, Abou El-Magd RM, Xiao J, Lewis CW, Tilli TM, Arakawa K, Nindita Y, Chan G, Sun L, Glover M, Klobukowski M, Tuszynski J. Ayoub AT, et al. J Med Chem. 2016 Oct 27;59(20):9532-9540. doi: 10.1021/acs.jmedchem.6b01264. Epub 2016 Oct 18. J Med Chem. 2016. PMID: 27718573

3

Explaining the Microtubule Energy Balance: Contributions Due to Dipole Moments, Charges, van der Waals and Solvation Energy.

Ayoub AT, Staelens M, Prunotto A, Deriu MA, Danani A, Klobukowski M, Tuszynski JA. Ayoub AT, et al. Int J Mol Sci. 2017 Sep 22;18(10):2042. doi: 10.3390/ijms18102042. Int J Mol Sci. 2017. PMID: 28937650 Free PMC article.

4

Similarity-based virtual screening for microtubule stabilizers reveals novel antimitotic scaffold.

Ayoub AT, Klobukowski M, Tuszynski J. Ayoub AT, et al. J Mol Graph Model. 2013 Jul;44:188-96. doi: 10.1016/j.jmgm.2013.05.008. Epub 2013 Jun 25. J Mol Graph Model. 2013. PMID: 23871820

5

Analysis of the strength of interfacial hydrogen bonds between tubulin dimers using quantum theory of atoms in molecules.

Ayoub AT, Craddock TJA, Klobukowski M, Tuszynski J. Ayoub AT, et al. Biophys J. 2014 Aug 5;107(3):740-750. doi: 10.1016/j.bpj.2014.05.047. Biophys J. 2014. PMID: 25099813 Free PMC article.

6

Detailed Per-residue Energetic Analysis Explains the Driving Force for Microtubule Disassembly.

Ayoub AT, Klobukowski M, Tuszynski JA. Ayoub AT, et al. PLoS Comput Biol. 2015 Jun 1;11(6):e1004313. doi: 10.1371/journal.pcbi.1004313. eCollection 2015 Jun. PLoS Comput Biol. 2015. PMID: 26030285 Free PMC article.

7

Designing and Testing of Novel Taxanes to Probe the Highly Complex Mechanisms by Which Taxanes Bind to Microtubules and Cause Cytotoxicity to Cancer Cells.

St George M, Ayoub AT, Banerjee A, Churchill CD, Winter P, Klobukowski M, Cass CE, Ludueña RF, Tuszynski JA, Damaraju S. St George M, et al. Among authors: ayoub at. PLoS One. 2015 Jun 8;10(6):e0129168. doi: 10.1371/journal.pone.0129168. eCollection 2015. PLoS One. 2015. PMID: 26052950 Free PMC article.

8

Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin.

Spasevska I, Ayoub AT, Winter P, Preto J, Wong GK, Dumontet C, Tuszynski JA. Spasevska I, et al. Among authors: ayoub at. Int J Mol Sci. 2017 Aug 2;18(8):1676. doi: 10.3390/ijms18081676. Int J Mol Sci. 2017. PMID: 28767055 Free PMC article.

9

Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents.

Minu M, Singh D, Mahaddalkar T, Lopus M, Winter P, Ayoub AT, Missiaen K, Tilli TM, Pasdar M, Tuszynski J. Minu M, et al. Among authors: ayoub at. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3855-61. doi: 10.1016/j.bmcl.2016.07.025. Epub 2016 Jul 9. Bioorg Med Chem Lett. 2016. PMID: 27449957

10

Tubulin response to intense nanosecond-scale electric field in molecular dynamics simulation.

Marracino P, Havelka D, Průša J, Liberti M, Tuszynski J, Ayoub AT, Apollonio F, Cifra M. Marracino P, et al. Among authors: ayoub at. Sci Rep. 2019 Jul 19;9(1):10477. doi: 10.1038/s41598-019-46636-4. Sci Rep. 2019. PMID: 31324834 Free PMC article.

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