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BRCA1 involvement in toxicological responses and human cancer etiology.
Georgakilas AG, Aziz K, Ziech D, Georgakila S, Panayiotidis MI. Georgakilas AG, et al. Toxicol Lett. 2009 Jul 24;188(2):77-83. doi: 10.1016/j.toxlet.2009.04.006. Epub 2009 Apr 16. Toxicol Lett. 2009. PMID: 19375487 Review.
Epigenetic inactivation of DNA repair in breast cancer.
Nowsheen S, Aziz K, Tran PT, Gorgoulis VG, Yang ES, Georgakilas AG. Nowsheen S, et al. Cancer Lett. 2014 Jan 28;342(2):213-22. doi: 10.1016/j.canlet.2012.05.015. Epub 2012 May 23. Cancer Lett. 2014. PMID: 22634493 Review.
Molecular markers for cancer prognosis and treatment: have we struck gold?
Nowsheen S, Aziz K, Panayiotidis MI, Georgakilas AG. Nowsheen S, et al. Cancer Lett. 2012 Dec 31;327(1-2):142-52. doi: 10.1016/j.canlet.2011.11.022. Epub 2011 Nov 25. Cancer Lett. 2012. PMID: 22120674 Review.
Toxicity and adverse effects of Tamoxifen and other anti-estrogen drugs.
Yang G, Nowsheen S, Aziz K, Georgakilas AG. Yang G, et al. Pharmacol Ther. 2013 Sep;139(3):392-404. doi: 10.1016/j.pharmthera.2013.05.005. Epub 2013 May 24. Pharmacol Ther. 2013. PMID: 23711794 Review.
DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
Peddi P, Loftin CW, Dickey JS, Hair JM, Burns KJ, Aziz K, Francisco DC, Panayiotidis MI, Sedelnikova OA, Bonner WM, Winters TA, Georgakilas AG. Peddi P, et al. Free Radic Biol Med. 2010 May 15;48(10):1435-43. doi: 10.1016/j.freeradbiomed.2010.02.033. Epub 2010 Mar 1. Free Radic Biol Med. 2010. PMID: 20193758 Free PMC article.
., chemical inactivation of its kinase activity by the novel inhibitors IC86621 and NU7026, knockdown and complete absence of the protein in human breast cancer (MCF-7) and glioblastoma cell lines (MO59-J/K). ...
., chemical inactivation of its kinase activity by the novel inhibitors IC86621 and NU7026, knockdown and complete absence of the protein in …
Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues.
Nowsheen S, Wukovich RL, Aziz K, Kalogerinis PT, Richardson CC, Panayiotidis MI, Bonner WM, Sedelnikova OA, Georgakilas AG. Nowsheen S, et al. Mutat Res. 2009 Mar 31;674(1-2):131-6. doi: 10.1016/j.mrgentox.2008.09.010. Epub 2008 Oct 2. Mutat Res. 2009. PMID: 18948225 Free PMC article.
Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice.
Aziz K, Limzerwala JF, Sturmlechner I, Hurley E, Zhang C, Jeganathan KB, Nelson G, Bronk S, Fierro Velasco RO, van Deursen EJ, O'Brien DR, Kocher JA, Youssef SA, van Ree JH, de Bruin A, van den Bos H, Spierings DCJ, Foijer F, van de Sluis B, Roberts LR, Gores GJ, Li H, van Deursen JM. Aziz K, et al. Gastroenterology. 2019 Jul;157(1):210-226.e12. doi: 10.1053/j.gastro.2019.03.016. Epub 2019 Mar 13. Gastroenterology. 2019. PMID: 30878468 Free PMC article.
The twist box domain is required for Twist1-induced prostate cancer metastasis.
Gajula RP, Chettiar ST, Williams RD, Thiyagarajan S, Kato Y, Aziz K, Wang R, Gandhi N, Wild AT, Vesuna F, Ma J, Salih T, Cades J, Fertig E, Biswal S, Burns TF, Chung CH, Rudin CM, Herman JM, Hales RK, Raman V, An SS, Tran PT. Gajula RP, et al. Mol Cancer Res. 2013 Nov;11(11):1387-400. doi: 10.1158/1541-7786.MCR-13-0218-T. Epub 2013 Aug 27. Mol Cancer Res. 2013. PMID: 23982216 Free PMC article.
Inhibition of TWIST1 leads to activation of oncogene-induced senescence in oncogene-driven non-small cell lung cancer.
Burns TF, Dobromilskaya I, Murphy SC, Gajula RP, Thiyagarajan S, Chatley SN, Aziz K, Cho YJ, Tran PT, Rudin CM. Burns TF, et al. Mol Cancer Res. 2013 Apr;11(4):329-38. doi: 10.1158/1541-7786.MCR-12-0456. Epub 2013 Jan 30. Mol Cancer Res. 2013. PMID: 23364532 Free PMC article.
Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis.
Tran PT, Shroff EH, Burns TF, Thiyagarajan S, Das ST, Zabuawala T, Chen J, Cho YJ, Luong R, Tamayo P, Salih T, Aziz K, Adam SJ, Vicent S, Nielsen CH, Withofs N, Sweet-Cordero A, Gambhir SS, Rudin CM, Felsher DW. Tran PT, et al. PLoS Genet. 2012;8(5):e1002650. doi: 10.1371/journal.pgen.1002650. Epub 2012 May 24. PLoS Genet. 2012. PMID: 22654667 Free PMC article.
To date, the identification of drugs to therapeutically inhibit K-RAS have been unsuccessful, suggesting that other approaches are required. ...
To date, the identification of drugs to therapeutically inhibit K-RAS have been unsuccessful, suggesting that other approaches are re …
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