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Page 1
Azoximer Bromide: Mystery, Serendipity, and Promise.
Grivtsova LY, Falaleeva NA, Tupitsyn NN. Grivtsova LY, et al. Front Oncol. 2021 Sep 10;11:699546. doi: 10.3389/fonc.2021.699546. eCollection 2021. Front Oncol. 2021. PMID: 34568029 Free PMC article. Review.
Azoximer bromide (AZB) was identified as an immunomodulator, and was initially developed and currently successfully indicated as one of several natural polyelectrolytes, a vaccine adjuvant, and an effective agent for the treatment of infectious and inflammatory dise …
Azoximer bromide (AZB) was identified as an immunomodulator, and was initially developed and currently successfully indicated …
Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer.
Rossi JF, Frayssinet P, Matciyak M, Tupitsyn N. Rossi JF, et al. Cancer Biol Med. 2024 Feb 5;20(12):1021-34. doi: 10.20892/j.issn.2095-3941.2023.0222. Cancer Biol Med. 2024. PMID: 38318840 Free PMC article. Review.
Few immune adjuvants are used as drugs. Hydroxyapatite (HA) ceramics and azoximer bromide (AZB) are overlooked molecules that were used in early clinical trials, which demonstrated clinical efficacy and excellent tolerance profiles. ...
Few immune adjuvants are used as drugs. Hydroxyapatite (HA) ceramics and azoximer bromide (AZB) are overlooked molecules that …
Analysis of the safety and immunogenicity profile of an azoximer bromide polymer-adjuvanted subunit influenza vaccine.
Kompier R, Neels P, Beyer W, Hardman T, Lioznov D, Kharit S, Kostinov M. Kompier R, et al. F1000Res. 2022 Mar 2;11:259. doi: 10.12688/f1000research.75869.2. eCollection 2022. F1000Res. 2022. PMID: 36176546 Free PMC article.
A systematic review of clinical trials conducted with a low-dose inactivated influenza vaccine adjuvanted by azoximer bromide (AZB, Polyoxidonium), was performed to compare vaccine reactogenicity against non-adjuvant vaccines. ...
A systematic review of clinical trials conducted with a low-dose inactivated influenza vaccine adjuvanted by azoximer bromide …
[Immunomodulators for the prevention and treatment of acute respiratory infections: efficacy of azoximer bromide].
Bulgakova VA. Bulgakova VA. Ter Arkh. 2014;86(12):92-7. doi: 10.17116/terarkh2014861292-97. Ter Arkh. 2014. PMID: 25804048 Review. Russian.
The review gives the results of a many-sided study of the basic properties of the therapeutic molecule of azoximer bromide (polyoxidonium). It analyzes our experience with the immunomodulator used to treat acute respiratory infections. ...In addition, the drug has a …
The review gives the results of a many-sided study of the basic properties of the therapeutic molecule of azoximer bromide (po …
The effect of azoximer bromide (Polyoxidonium) in patients hospitalized with coronavirus disease (COVID-19): an open-label, multicentre, interventional clinical study.
Efimov SV, Matsiyeuskaya NV, Boytsova OV, Akhieva LY, Kvasova EI, Harrison F, Karpova YS, Tikhonov A, Khomyakova NF, Hardman T, Rossi JF. Efimov SV, et al. Drugs Context. 2021 Mar 25;10:2020-11-1. doi: 10.7573/dic.2020-11-1. eCollection 2021. Drugs Context. 2021. PMID: 33828607 Free PMC article.
A clinical need for aetiotropic coronavirus disease (COVID-19) treatments is required. The immune modulator azoximer bromide (AZB; Polyoxidonium) is indicated in Russia for use against acute viral infections and during remission. ...
A clinical need for aetiotropic coronavirus disease (COVID-19) treatments is required. The immune modulator azoximer bromide ( …
[A comparative study of the effectiveness of azoximer bromide and surgery on the quality of the life of patients with chronic rhinosinusitis without nasal polyps].
Svistushkin VM, Nikiforova GN, Dekhanov AS, Nikiforova AN. Svistushkin VM, et al. Vestn Otorinolaringol. 2024;89(2):46-51. doi: 10.17116/otorino20248902146. Vestn Otorinolaringol. 2024. PMID: 38805463 Russian.
Patients, depending on their choice, were treated with functional endoscopic intervention or a course of 6 mg/ml azoximer bromide (1 ml per day, a course of at least 10 days). RESULTS: The median [interquartile range] score for VAS in patients before azoximer …
Patients, depending on their choice, were treated with functional endoscopic intervention or a course of 6 mg/ml azoximer bromide …
Open-label use of an aliphatic polyamine immunomodulator in patients hospitalized with COVID-19.
Efimov SV, Matsiyeuskaya NV, Boytsova OV, Akhieva LY, Kuntsevich EV, Troshina AA, Kvasova EI, Tikhonov AA, Khomyakova NF, Harrison F, Rossi JF, Hardman TC. Efimov SV, et al. Drugs Context. 2022 Mar 3;11:2022-1-1. doi: 10.7573/dic.2022-1-1. eCollection 2022. Drugs Context. 2022. PMID: 35310299 Free PMC article.
BACKGROUND: Evidence-based therapies used to treat coronavirus disease (COVID-19) remain limited. Azoximer bromide (AZB; Polyoxidonium()) is an immunomodulating molecule frequently used in the Russian Federation. ...
BACKGROUND: Evidence-based therapies used to treat coronavirus disease (COVID-19) remain limited. Azoximer bromide (AZB; Polyo …
Polyoxidonium® Activates Cytotoxic Lymphocyte Responses Through Dendritic Cell Maturation: Clinical Effects in Breast Cancer.
Alexia C, Cren M, Louis-Plence P, Vo DN, El Ahmadi Y, Dufourcq-Lopez E, Lu ZY, Hernandez J, Shamilov F, Chernysheva O, Vasilieva M, Vorotnikov I, Vishnevskay Y, Tupitsyn N, Rossi JF, Villalba M. Alexia C, et al. Front Immunol. 2019 Nov 28;10:2693. doi: 10.3389/fimmu.2019.02693. eCollection 2019. Front Immunol. 2019. PMID: 31849934 Free PMC article. Clinical Trial.
However, despite their long-time use, only a few adjuvants are licensed today, and their use in cancer treatment is rare. Azoximer bromide, marketed under the trade name Polyoxidonium (PO), is a copolymer of N-oxidized 1,4-ethylenepiperazine and (N-carboxyethyl)-1,4 …
However, despite their long-time use, only a few adjuvants are licensed today, and their use in cancer treatment is rare. Azoximer …
[Immunomodulatory therapy in the postoperative period in chronic purulent otitis media].
Saidov ZM, Dzhamaludinov YA, Diab KM, Khanaliev VY, Krivtsov AV, Saidov MZ. Saidov ZM, et al. Vestn Otorinolaringol. 2024;89(6):10-17. doi: 10.17116/otorino20248906110. Vestn Otorinolaringol. 2024. PMID: 39729375 Russian.
OBJECTIVE: To study the clinical and immunologic effectiveness of azoximer bromide in the postoperative period during tympanoplasty in CPOM patients. MATERIAL AND METHODS: Forty-nine patients with mesotympanitis and epitympanitis were examined. ...
OBJECTIVE: To study the clinical and immunologic effectiveness of azoximer bromide in the postoperative period during tympanop …
48 results