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Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma.
Zavidij O, Haradhvala NJ, Mouhieddine TH, Sklavenitis-Pistofidis R, Cai S, Reidy M, Rahmat M, Flaifel A, Ferland B, Su NK, Agius MP, Park J, Manier S, Bustoros M, Huynh D, Capelletti M, Berrios B, Liu CJ, He MX, Braggio E, Fonseca R, Maruvka YE, Guerriero JL, Goldman M, Van Allen EM, McCarroll SA, Azzi J, Getz G, Ghobrial IM. Zavidij O, et al. Among authors: azzi j. Nat Cancer. 2020 May;1(5):493-506. doi: 10.1038/s43018-020-0053-3. Epub 2020 Apr 27. Nat Cancer. 2020. PMID: 33409501 Free PMC article.
Multiple Myeloma and the Immune Microenvironment.
Kawano Y, Roccaro AM, Ghobrial IM, Azzi J. Kawano Y, et al. Among authors: azzi j. Curr Cancer Drug Targets. 2017;17(9):806-818. doi: 10.2174/1568009617666170214102301. Curr Cancer Drug Targets. 2017. PMID: 28201978 Review.
Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression.
Kawano Y, Zavidij O, Park J, Moschetta M, Kokubun K, Mouhieddine TH, Manier S, Mishima Y, Murakami N, Bustoros M, Pistofidis RS, Reidy M, Shen YJ, Rahmat M, Lukyanchykov P, Karreci ES, Tsukamoto S, Shi J, Takagi S, Huynh D, Sacco A, Tai YT, Chesi M, Bergsagel PL, Roccaro AM, Azzi J, Ghobrial IM. Kawano Y, et al. Among authors: azzi j. J Clin Invest. 2018 Jun 1;128(6):2487-2499. doi: 10.1172/JCI88169. Epub 2018 May 14. J Clin Invest. 2018. PMID: 29558366 Free PMC article.
Antibody-Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab.
Kurdi AT, Glavey SV, Bezman NA, Jhatakia A, Guerriero JL, Manier S, Moschetta M, Mishima Y, Roccaro A, Detappe A, Liu CJ, Sacco A, Huynh D, Tai YT, Robbins MD, Azzi J, Ghobrial IM. Kurdi AT, et al. Among authors: azzi j. Mol Cancer Ther. 2018 Jul;17(7):1454-1463. doi: 10.1158/1535-7163.MCT-17-0998. Epub 2018 Apr 13. Mol Cancer Ther. 2018. PMID: 29654064 Free PMC article.
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.
Sula Karreci E, Fan H, Uehara M, Mihali AB, Singh PK, Kurdi AT, Solhjou Z, Riella LV, Ghobrial I, Laragione T, Routray S, Assaker JP, Wang R, Sukenick G, Shi L, Barrat FJ, Nathan CF, Lin G, Azzi J. Sula Karreci E, et al. Among authors: azzi j. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8425-E8432. doi: 10.1073/pnas.1618548114. Epub 2016 Dec 12. Proc Natl Acad Sci U S A. 2016. PMID: 27956634 Free PMC article.
Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.
Uehara M, McGrath MM, Ohori S, Solhjou Z, Banouni N, Routray S, Evans C, DiNitto JP, Elkhal A, Turka LA, Strom TB, Tullius SG, Winkler DG, Azzi J, Abdi R. Uehara M, et al. Among authors: azzi j. Nat Commun. 2017 Oct 16;8(1):951. doi: 10.1038/s41467-017-00982-x. Nat Commun. 2017. PMID: 29038423 Free PMC article.
Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation.
Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Sula Karreci E, et al. Among authors: azzi j. JCI Insight. 2017 Nov 2;2(21):e91599. doi: 10.1172/jci.insight.91599. JCI Insight. 2017. PMID: 29093262 Free PMC article.
Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms.
Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV. Magee CN, et al. Among authors: azzi j. Circulation. 2019 Sep 9;140(10):846-863. doi: 10.1161/CIRCULATIONAHA.119.040563. Epub 2019 Jul 3. Circulation. 2019. PMID: 31266349 Free PMC article.
Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts.
Choi JY, Eskandari SK, Cai S, Sulkaj I, Assaker JP, Allos H, AlHaddad J, Muhsin SA, Alhussain E, Mansouri A, Yeung MY, Seelen MAJ, Kim HJ, Cantor H, Azzi JR. Choi JY, et al. Among authors: azzi jr. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6042-6046. doi: 10.1073/pnas.1918950117. Epub 2020 Feb 28. Proc Natl Acad Sci U S A. 2020. PMID: 32111690 Free PMC article.
Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo.
Cai S, Choi JY, Borges TJ, Zhang H, Miao J, Ichimura T, Li X, Xu S, Chu P, Eskandari SK, Allos H, Alhaddad JB, Muhsin SA, Yatim K, Riella LV, Sage PT, Chandraker AK, Azzi JR. Cai S, et al. Among authors: azzi jr. Sci Rep. 2020 Aug 28;10(1):14249. doi: 10.1038/s41598-020-71289-z. Sci Rep. 2020. PMID: 32859934 Free PMC article.
161 results