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Page 1
Application of Proteomics in Sarcoidosis.
Guerrero CR, Maier LA, Griffin TJ, Higgins L, Najt CP, Perlman DM, Bhargava M. Guerrero CR, et al. Am J Respir Cell Mol Biol. 2020 Dec;63(6):727-738. doi: 10.1165/rcmb.2020-0070PS. Am J Respir Cell Mol Biol. 2020. PMID: 32804537 Review.
These studies identified several differentially expressed proteins, including protocadherin-2 precursor, annexin A2, pulmonary surfactant A2, complement factors C3, vitamin-D-binding protein, cystatin B, and amyloid P, comparing subjects with sarcoidosis with control subjects. Ot …
These studies identified several differentially expressed proteins, including protocadherin-2 precursor, annexin A2, pulmonary surfactant A2 …
Cerebrospinal Fluid Apolipoprotein E Levels in Delirium.
Caplan GA, Tai J, Mohd Hanizan F, McVeigh CL, Hill MA, Poljak A. Caplan GA, et al. Dement Geriatr Cogn Dis Extra. 2017 Jul 11;7(2):240-248. doi: 10.1159/000477847. eCollection 2017 May-Aug. Dement Geriatr Cogn Dis Extra. 2017. PMID: 28868067 Free PMC article.
There was a reduction in absolute CSF apolipoprotein E level during delirium (median [interquartile range]: 9.55 mug/mL [5.65-15.05] vs. 16.86 mug/mL [14.82-20.88]; p = 0.016) but no differences in apolipoprotein A1, B, C3, H, and J. There were no differences …
There was a reduction in absolute CSF apolipoprotein E level during delirium (median [interquartile range]: 9.55 mug/mL [5.65-15.05] vs. 16. …
IL-17A deficiency mitigates bleomycin-induced complement activation during lung fibrosis.
Cipolla E, Fisher AJ, Gu H, Mickler EA, Agarwal M, Wilke CA, Kim KK, Moore BB, Vittal R. Cipolla E, et al. FASEB J. 2017 Dec;31(12):5543-5556. doi: 10.1096/fj.201700289R. Epub 2017 Aug 17. FASEB J. 2017. PMID: 28821630 Free PMC article.
Microarray analyses of mRNA isolated from primary normal human small airway epithelial cells indicated that IL-17A (100 ng/ml; 24 h; n = 5 donor lungs) induces C' components (C' factor B, C3, and GPCR kinase isoform 5), cytokines (IL8, -6, and -1B), and cytokine lig …
Microarray analyses of mRNA isolated from primary normal human small airway epithelial cells indicated that IL-17A (100 ng/ml; 24 h; n = 5 d …
Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis.
Lee JD, Kamaruzaman NA, Fung JN, Taylor SM, Turner BJ, Atkin JD, Woodruff TM, Noakes PG. Lee JD, et al. J Neuroinflammation. 2013 Sep 26;10:119. doi: 10.1186/1742-2094-10-119. J Neuroinflammation. 2013. PMID: 24067070 Free PMC article.
This study therefore aimed to determine the expression of complement components (C1qB, C4, factor B, C3/C3b, C5 and CD88) and regulators (CD55 and CD59a) in the lumbar spinal cord of hSOD1(G93A) mice during defined disease stages. ...
This study therefore aimed to determine the expression of complement components (C1qB, C4, factor B, C3/C3b, C5 and CD88) and …
Proteomic profiling following immunoaffinity capture of high-density lipoprotein: association of acute-phase proteins and complement factors with proinflammatory high-density lipoprotein in rheumatoid arthritis.
Watanabe J, Charles-Schoeman C, Miao Y, Elashoff D, Lee YY, Katselis G, Lee TD, Reddy ST. Watanabe J, et al. Arthritis Rheum. 2012 Jun;64(6):1828-37. doi: 10.1002/art.34363. Epub 2012 Jan 9. Arthritis Rheum. 2012. PMID: 22231638 Free PMC article.
These proteins included the acute-phase proteins apolipoprotein J, fibrinogen, haptoglobin, serum amyloid A, and complement factors (B, C3, and C9). ...
These proteins included the acute-phase proteins apolipoprotein J, fibrinogen, haptoglobin, serum amyloid A, and complement factors ( …
Quantitative iTRAQ-Based Proteomic Identification of Candidate Biomarkers for Diabetic Nephropathy in Plasma of Type 1 Diabetic Patients.
Overgaard AJ, Thingholm TE, Larsen MR, Tarnow L, Rossing P, McGuire JN, Pociot F. Overgaard AJ, et al. Clin Proteomics. 2010 Dec;6(4):105-114. doi: 10.1007/s12014-010-9053-0. Epub 2010 Sep 10. Clin Proteomics. 2010. PMID: 21124997 Free PMC article.
The results were further analysed with ingenuity pathway analysis. Levels of apolipoprotein A1, A2, B, C3, E and J were analysed and validated by a multiplex immunoassay in 20 type 1 diabetic patients with macroalbuminuria and 10 with normoalbuminuria. ...The …
The results were further analysed with ingenuity pathway analysis. Levels of apolipoprotein A1, A2, B, C3, E and J were …
Differential role of Rho GTPases in intestinal epithelial barrier regulation in vitro.
Schlegel N, Meir M, Spindler V, Germer CT, Waschke J. Schlegel N, et al. J Cell Physiol. 2011 May;226(5):1196-203. doi: 10.1002/jcp.22446. J Cell Physiol. 2011. PMID: 20945370
We tested the effects of Rho GTPase activities on intestinal epithelial barrier functions by using the bacterial toxins cytotoxic necrotizing factor 1 (CNF-1), toxin B, C3 transferase (C3 TF), and lethal toxin (LT) in an in vitro model of the intestinal epithelial b …
We tested the effects of Rho GTPase activities on intestinal epithelial barrier functions by using the bacterial toxins cytotoxic necrotizin …
Dynamics of human complement-mediated killing of Klebsiella pneumoniae.
Nypaver CM, Thornton MM, Yin SM, Bracho DO, Nelson PW, Jones AE, Bortz DM, Younger JG. Nypaver CM, et al. Am J Respir Cell Mol Biol. 2010 Nov;43(5):585-90. doi: 10.1165/rcmb.2009-0292OC. Epub 2009 Dec 11. Am J Respir Cell Mol Biol. 2010. PMID: 20008281 Free PMC article.
Using Factor B-depleted serum, the alternative pathway was found to be the primary bactericidal effector: In the absence of B, C3 opsonization as measured by flow cytometry did not progress and bacteria proliferated near exponentially. ...
Using Factor B-depleted serum, the alternative pathway was found to be the primary bactericidal effector: In the absence of B, C3 …
Electrochemical and density functional theory study on the reactivity of fisetin and its radicals: implications on in vitro antioxidant activity.
Marković ZS, Mentus SV, Dimitrić Marković JM. Marković ZS, et al. J Phys Chem A. 2009 Dec 24;113(51):14170-9. doi: 10.1021/jp907071v. J Phys Chem A. 2009. PMID: 19954196
The three voltametrically detectable consecutive steps, reflected the fisetin molecular structure, catecholic structural unit in the ring B, C3-OH, and C7-OH groups in the rings C and A. Oxidation potential values, used as quantitative parameter in determining its o …
The three voltametrically detectable consecutive steps, reflected the fisetin molecular structure, catecholic structural unit in the ring …
Mutations in proteins of the alternative pathway of complement and the pathogenesis of atypical hemolytic uremic syndrome.
Abarrategui-Garrido C, Melgosa M, Peña-Carrión A, de Jorge EG, de Córdoba SR, López-Trascasa M, Sánchez-Corral P. Abarrategui-Garrido C, et al. Am J Kidney Dis. 2008 Jul;52(1):171-80. doi: 10.1053/j.ajkd.2008.01.026. Epub 2008 Apr 18. Am J Kidney Dis. 2008. PMID: 18423815
Atypical hemolytic uremic syndrome is associated with mutations in the complement proteins factor H, factor I, factor B, C3, or membrane cofactor protein in about 50% of patients. The evolution and prognosis of the disease in patients carrying mutations in factor H …
Atypical hemolytic uremic syndrome is associated with mutations in the complement proteins factor H, factor I, factor B, C3, o …
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