Böttcher J - Search Results

1

The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.

Schneider EV, Böttcher J, Blaesse M, Neumann L, Huber R, Maskos K. Schneider EV, et al. Among authors: bottcher j. J Mol Biol. 2011 Sep 16;412(2):251-66. doi: 10.1016/j.jmb.2011.07.020. Epub 2011 Jul 23. J Mol Biol. 2011. PMID: 21806996

2

Structure-kinetic relationship study of CDK8/CycC specific compounds.

Schneider EV, Böttcher J, Huber R, Maskos K, Neumann L. Schneider EV, et al. Among authors: bottcher j. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8081-6. doi: 10.1073/pnas.1305378110. Epub 2013 Apr 29. Proc Natl Acad Sci U S A. 2013. PMID: 23630251 Free PMC article.

3

Two solutions for the same problem: multiple binding modes of pyrrolidine-based HIV-1 protease inhibitors.

Blum A, Böttcher J, Dörr S, Heine A, Klebe G, Diederich WE. Blum A, et al. Among authors: bottcher j. J Mol Biol. 2011 Jul 22;410(4):745-55. doi: 10.1016/j.jmb.2011.04.052. J Mol Biol. 2011. PMID: 21762812

4

Structural and kinetic analysis of pyrrolidine-based inhibitors of the drug-resistant Ile84Val mutant of HIV-1 protease.

Böttcher J, Blum A, Heine A, Diederich WE, Klebe G. Böttcher J, et al. J Mol Biol. 2008 Nov 7;383(2):347-57. doi: 10.1016/j.jmb.2008.07.062. Epub 2008 Jul 29. J Mol Biol. 2008. PMID: 18692068

5

Key factors for successful generation of protein-fragment structures requirement on protein, crystals, and technology.

Böttcher J, Jestel A, Kiefersauer R, Krapp S, Nagel S, Steinbacher S, Steuber H. Böttcher J, et al. Methods Enzymol. 2011;493:61-89. doi: 10.1016/B978-0-12-381274-2.00003-0. Methods Enzymol. 2011. PMID: 21371587

6

Unexpected novel binding mode of pyrrolidine-based aspartyl protease inhibitors: design, synthesis and crystal structure in complex with HIV protease.

Specker E, Böttcher J, Brass S, Heine A, Lilie H, Schoop A, Müller G, Griebenow N, Klebe G. Specker E, et al. Among authors: bottcher j. ChemMedChem. 2006 Jan;1(1):106-17. doi: 10.1002/cmdc.200500008. ChemMedChem. 2006. PMID: 16892342

7

Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance.

Hofmann MH, Mani R, Engelhardt H, Impagnatiello MA, Carotta S, Kerenyi M, Lorenzo-Herrero S, Böttcher J, Scharn D, Arnhof H, Zoephel A, Schnitzer R, Gerstberger T, Sanderson MP, Rajgolikar G, Goswami S, Vasu S, Ettmayer P, Gonzalez S, Pearson M, McConnell DB, Kraut N, Muthusamy N, Moll J. Hofmann MH, et al. Among authors: bottcher j. Mol Cancer Ther. 2020 Apr;19(4):1018-1030. doi: 10.1158/1535-7163.MCT-19-0789. Epub 2020 Feb 5. Mol Cancer Ther. 2020. PMID: 32024684 Free PMC article.

8

Hydroxyethylene sulfones as a new scaffold to address aspartic proteases: design, synthesis, and structural characterization.

Specker E, Böttcher J, Heine A, Sotriffer CA, Lilie H, Schoop A, Müller G, Griebenow N, Klebe G. Specker E, et al. Among authors: bottcher j. J Med Chem. 2005 Oct 20;48(21):6607-19. doi: 10.1021/jm050224y. J Med Chem. 2005. PMID: 16220977

9

Targeting the open-flap conformation of HIV-1 protease with pyrrolidine-based inhibitors.

Böttcher J, Blum A, Dörr S, Heine A, Diederich WE, Klebe G. Böttcher J, et al. ChemMedChem. 2008 Sep;3(9):1337-44. doi: 10.1002/cmdc.200800113. ChemMedChem. 2008. PMID: 18720485

10

Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors.

Blum A, Böttcher J, Sammet B, Luksch T, Heine A, Klebe G, Diederich WE. Blum A, et al. Among authors: bottcher j. Bioorg Med Chem. 2008 Sep 15;16(18):8574-86. doi: 10.1016/j.bmc.2008.08.012. Epub 2008 Aug 7. Bioorg Med Chem. 2008. PMID: 18760609

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