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Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.
Lu Y, Hardes K, Dahms SO, Böttcher-Friebertshäuser E, Steinmetzer T, Than ME, Klenk HD, Garten W. Lu Y, et al. Antiviral Res. 2015 Aug;120:89-100. doi: 10.1016/j.antiviral.2015.05.006. Epub 2015 May 26. Antiviral Res. 2015. PMID: 26022200
Optimization of Substrate-Analogue Furin Inhibitors.
Ivanova T, Hardes K, Kallis S, Dahms SO, Than ME, Künzel S, Böttcher-Friebertshäuser E, Lindberg I, Jiao GS, Bartenschlager R, Steinmetzer T. Ivanova T, et al. ChemMedChem. 2017 Dec 7;12(23):1953-1968. doi: 10.1002/cmdc.201700596. Epub 2017 Nov 16. ChemMedChem. 2017. PMID: 29059503
Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia.
Kalymbetova TV, Selvakumar B, Rodríguez-Castillo JA, Gunjak M, Malainou C, Heindl MR, Moiseenko A, Chao CM, Vadász I, Mayer K, Lohmeyer J, Bellusci S, Böttcher-Friebertshäuser E, Seeger W, Herold S, Morty RE. Kalymbetova TV, et al. J Pathol. 2018 Jun;245(2):153-159. doi: 10.1002/path.5076. Epub 2018 Apr 18. J Pathol. 2018. PMID: 29574785
40 results