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Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.
Jensen AA, Christesen T, Bølcho U, Greenwood JR, Postorino G, Vogensen SB, Johansen TN, Egebjerg J, Bräuner-Osborne H, Clausen RP. Jensen AA, et al. Among authors: bolcho u. J Med Chem. 2007 Aug 23;50(17):4177-85. doi: 10.1021/jm070532r. Epub 2007 Aug 2. J Med Chem. 2007. PMID: 17672447
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
Vogensen SB, Frydenvang K, Greenwood JR, Postorino G, Nielsen B, Pickering DS, Ebert B, Bølcho U, Egebjerg J, Gajhede M, Kastrup JS, Johansen TN, Clausen RP, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: bolcho u. J Med Chem. 2007 May 17;50(10):2408-14. doi: 10.1021/jm061439q. Epub 2007 Apr 25. J Med Chem. 2007. PMID: 17455929
Design, synthesis, and pharmacological characterization of polyamine toxin derivatives: potent ligands for the pore-forming region of AMPA receptors.
Jensen LS, Bølcho U, Egebjerg J, Strømgaard K. Jensen LS, et al. Among authors: bolcho u. ChemMedChem. 2006 Apr;1(4):419-28. doi: 10.1002/cmdc.200500093. ChemMedChem. 2006. PMID: 16892377
Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives.
Andersen TF, Tikhonov DB, Bølcho U, Bolshakov K, Nelson JK, Pluteanu F, Mellor IR, Egebjerg J, Strømgaard K. Andersen TF, et al. Among authors: bolcho u. J Med Chem. 2006 Sep 7;49(18):5414-23. doi: 10.1021/jm060606j. J Med Chem. 2006. PMID: 16942015
The sorting receptor SorCS3 is a stronger regulator of glutamate receptor functions compared to GABAergic mechanisms in the hippocampus.
Christiansen GB, Andersen KH, Riis S, Nykjaer A, Bolcho U, Jensen MS, Holm MM. Christiansen GB, et al. Among authors: bolcho u. Hippocampus. 2017 Mar;27(3):235-248. doi: 10.1002/hipo.22689. Epub 2017 Feb 3. Hippocampus. 2017. PMID: 27935149
Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death.
Reimer L, Vesterager LB, Betzer C, Zheng J, Nielsen LD, Kofoed RH, Lassen LB, Bølcho U, Paludan SR, Fog K, Jensen PH. Reimer L, et al. Among authors: bolcho u. Neurobiol Dis. 2018 Jul;115:17-28. doi: 10.1016/j.nbd.2018.03.001. Epub 2018 Mar 1. Neurobiol Dis. 2018. PMID: 29501855
SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Glerup S, Bolcho U, Mølgaard S, Bøggild S, Vaegter CB, Smith AH, Nieto-Gonzalez JL, Ovesen PL, Pedersen LF, Fjorback AN, Kjolby M, Login H, Holm MM, Andersen OM, Nyengaard JR, Willnow TE, Jensen K, Nykjaer A. Glerup S, et al. Among authors: bolcho u. Mol Psychiatry. 2016 Dec;21(12):1740-1751. doi: 10.1038/mp.2016.108. Epub 2016 Jul 26. Mol Psychiatry. 2016. PMID: 27457814
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