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A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma.
Smith D, Helgason H, Sulem P, Bjornsdottir US, Lim AC, Sveinbjornsson G, Hasegawa H, Brown M, Ketchem RR, Gavala M, Garrett L, Jonasdottir A, Jonasdottir A, Sigurdsson A, Magnusson OT, Eyjolfsson GI, Olafsson I, Onundarson PT, Sigurdardottir O, Gislason D, Gislason T, Ludviksson BR, Ludviksdottir D, Boezen HM, Heinzmann A, Krueger M, Porsbjerg C, Ahluwalia TS, Waage J, Backer V, Deichmann KA, Koppelman GH, Bønnelykke K, Bisgaard H, Masson G, Thorsteinsdottir U, Gudbjartsson DF, Johnston JA, Jonsdottir I, Stefansson K. Smith D, et al. Among authors: bonnelykke k. PLoS Genet. 2017 Mar 8;13(3):e1006659. doi: 10.1371/journal.pgen.1006659. eCollection 2017 Mar. PLoS Genet. 2017. PMID: 28273074 Free PMC article.
Age dependent systemic exposure to inhaled salbutamol.
Bønnelykke K, Jespersen JJ, Bisgaard H. Bønnelykke K, et al. Br J Clin Pharmacol. 2007 Aug;64(2):241-4. doi: 10.1111/j.1365-2125.2007.02868.x. Epub 2007 Mar 1. Br J Clin Pharmacol. 2007. PMID: 17335545 Free PMC article. Clinical Trial.
Extrapolating evidence beyond age groups.
Bisgaard H, Bønnelykke K. Bisgaard H, et al. Among authors: bonnelykke k. J Allergy Clin Immunol. 2008 Apr;121(4):1066-7; author reply 1067-8. doi: 10.1016/j.jaci.2008.01.068. Epub 2008 Mar 5. J Allergy Clin Immunol. 2008. PMID: 18325574 No abstract available.
Sensitization does not develop in utero.
Bønnelykke K, Pipper CB, Bisgaard H. Bønnelykke K, et al. J Allergy Clin Immunol. 2008 Mar;121(3):646-51. doi: 10.1016/j.jaci.2007.12.1149. J Allergy Clin Immunol. 2008. PMID: 18328892
Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.
Bisgaard H, Bønnelykke K, Sleiman PM, Brasholt M, Chawes B, Kreiner-Møller E, Stage M, Kim C, Tavendale R, Baty F, Pipper CB, Palmer CN, Hakonarsson H. Bisgaard H, et al. Among authors: bonnelykke k. Am J Respir Crit Care Med. 2009 Feb 1;179(3):179-85. doi: 10.1164/rccm.200809-1436OC. Epub 2008 Nov 21. Am J Respir Crit Care Med. 2009. PMID: 19029000
289 results