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Page 1
Empiric azithromycin alters the upper respiratory microbiome and resistome without anti-inflammatory benefit in COVID-19.
Glascock A, Maguire C, Phan HV, Lydon EC, Schaenman J, Calfee CS, Melamed E, Greenland J, Corry DB, Kheradmand F, Baden LR, Sekaly R, McComsey GA, Haddad EK, Cairns CB, Geng LN, Pulendran B, Fernandez-Sesma A, Simon V, Metcalf JP, Agudelo Higuita NI, Messer WB, Davis MM, Nadeau KC, Kraft M, Bime C, Erle DJ, Atkinson MA, Brakenridge SC, Ehrlich LIR, Montgomery RR, Shaw AC, Hough CL, Hafler DA, Augustine AD, Becker PM, Peters B, Ozonoff A, Hoch A, Kim-Schulze S, Krammer F, Bosinger S, Eckalbar W, Altman MC, Wilson M, Guan L, Maecker H, Steen H; IMPACC Network; Diray-Arce J, Rouphael N, Kleinstein SH, Jayavelu ND, Reed EF, Levy O, Chu VT, Langelier CR. Glascock A, et al. Nat Microbiol. 2026 Apr;11(4):1100-1112. doi: 10.1038/s41564-026-02285-8. Epub 2026 Mar 16. Nat Microbiol. 2026. PMID: 41840216 Free PMC article.
We compared the upper respiratory microbiome, resistome and systemic immune response in patients treated with azithromycin (n = 366) with those who received no antibiotics (n = 474) or other antibiotics (n = 324). ...
We compared the upper respiratory microbiome, resistome and systemic immune response in patients treated with azithromycin (n = 366) …
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.
Ozonoff A, Jayavelu ND, Liu S, Melamed E, Milliren CE, Qi J, Geng LN, McComsey GA, Cairns CB, Baden LR, Schaenman J, Shaw AC, Samaha H, Seyfert-Margolis V, Krammer F, Rosen LB, Steen H, Syphurs C, Dandekar R, Shannon CP, Sekaly RP, Ehrlich LIR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NIA, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Sesma AF, Simon V, van Bakel H, Kim-Schulze S, Hafler DA, Levy O, Kraft M, Bime C, Haddad EK, Calfee CS, Erle DJ, Langelier CR, Eckalbar W, Bosinger SE; IMPACC Network; Peters B, Kleinstein SH, Reed EF, Augustine AD, Diray-Arce J, Maecker HT, Altman MC, Montgomery RR, Becker PM, Rouphael N. Ozonoff A, et al. Nat Commun. 2024 Jan 3;15(1):216. doi: 10.1038/s41467-023-44090-5. Nat Commun. 2024. PMID: 38172101 Free PMC article.
During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocyt …
During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers …
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients.
Pickering H, Schaenman J, Phan HV, Maguire C, Tsitsiklis A, Rouphael N, Higuita NIA, Atkinson MA, Brakenridge S, Fung M, Messer W; IMPACC Network; Salehi-Rad R, Altman MC, Becker PM, Bosinger SE, Eckalbar W, Hoch A, Doni Jayavelu N, Kim-Schulze S, Jenkins M, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Diray-Arce J, Shaw A, Baden L, Levy O, Reed EF, Langelier CR. Pickering H, et al. Nat Commun. 2025 Jan 10;16(1):586. doi: 10.1038/s41467-025-55823-z. Nat Commun. 2025. PMID: 39794319 Free PMC article.
In addition, transplant recipients exhibit decreased plasmablasts and transitional B cells, and increased senescent T cells. Blood and nasal transcriptional profiling demonstrate unexpected upregulation of innate immune signaling pathways and increased levels of several pr …
In addition, transplant recipients exhibit decreased plasmablasts and transitional B cells, and increased senescent T cells. Blood an …
Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort.
Jayavelu ND, Qi J, Milliren CE, Ozonoff A, Liu S, Levy O, Baden LR, Melamed E, McComsey GA, Cairns CB, Schaenman J, Shaw AC, Hafler DA, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Agudelo Higuita NI, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Geng LN, Sesma AF, Simon V, Krammer F, Bime C, Calfee CS, Bosinger SE, Eckalbar W, Steen H, Maecker HT; IMPACC Network; Augustine AD, Diray-Arce J, Haddad EK, Sekaly RP, Kraft M, Woodruff PG, Erle DJ, Ehrlich LIR, Montgomery RR, Becker PM, Altman MC, Fourati S. Jayavelu ND, et al. J Allergy Clin Immunol Glob. 2025 Jun 12;4(4):100515. doi: 10.1016/j.jacig.2025.100515. eCollection 2025 Nov. J Allergy Clin Immunol Glob. 2025. PMID: 40709330 Free PMC article.
This included the expression of T2-regulated genes implicated in T-/B-cell activation and apoptosis in nasal samples and the expression of T2-regulated genes implicated in myeloid differentiation and reactive oxygen species signaling in blood. ...
This included the expression of T2-regulated genes implicated in T-/B-cell activation and apoptosis in nasal samples and the expressi …
Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors.
Doni Jayavelu N, Samaha H, Wimalasena ST, Hoch A, Gygi JP, Gabernet G, Ozonoff A, Liu S, Milliren CE, Levy O, Baden LR, Melamed E, Ehrlich LIR, McComsey GA, Sekaly RP, Cairns CB, Haddad EK, Schaenman J, Shaw AC, Hafler DA, Montgomery RR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Agudelo Higuit NI, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Geng LN, Fernandez Sesma A, Simon V, Krammer F, Kraft M, Bime C, Calfee CS, Erle DJ, Langelier CR; IMPACC Network; Guan L, Maecker HT, Peters B, Kleinstein SH, Reed EF, Augustine AD, Diray-Arce J, Becker PM, Rouphael N, Altman MC. Doni Jayavelu N, et al. Commun Med (Lond). 2026 Jan 3;6(1):1. doi: 10.1038/s43856-025-01230-w. Commun Med (Lond). 2026. PMID: 41484172 Free PMC article.
Ablation of residual potentials along the circumferential line reduces acute pulmonary vein reconnection.
Tzeis S, Brusich S, Manola Š, Kojić D, Pernat A, Asvestas D, Xenos T, Bastiančić AL, Tomović M, Rauber M, Vardas P, Pavlović N. Tzeis S, et al. Hellenic J Cardiol. 2023 Jul-Aug;72:1-8. doi: 10.1016/j.hjc.2023.03.001. Epub 2023 Mar 11. Hellenic J Cardiol. 2023. PMID: 36907510 Free article. Clinical Trial.
Ipsilateral PV sets with RPs were randomized to either no further ablation (Group B) or to additional ablation of the identified RPs (Group C). The primary study endpoint was spontaneous or adenosine-mediated acute PV reconnection after a 30-min waiting period and was also …
Ipsilateral PV sets with RPs were randomized to either no further ablation (Group B) or to additional ablation of the identified RPs …
N-Acyl Dehydrotyrosines, Tyrosinase Inhibitors from the Marine Bacterium Thalassotalea sp. PP2-459.
Deering RW, Chen J, Sun J, Ma H, Dubert J, Barja JL, Seeram NP, Wang H, Rowley DC. Deering RW, et al. J Nat Prod. 2016 Feb 26;79(2):447-50. doi: 10.1021/acs.jnatprod.5b00972. Epub 2016 Jan 29. J Nat Prod. 2016. PMID: 26824128 Free PMC article.
Thalassotalic acids A-C and thalassotalamides A and B are new N-acyl dehydrotyrosine derivatives produced by Thalassotalea sp. PP2-459, a Gram-negative bacterium isolated from a marine bivalve aquaculture facility. ...Thalassotalic acid A (1) displays in vitro inhib …
Thalassotalic acids A-C and thalassotalamides A and B are new N-acyl dehydrotyrosine derivatives produced by Thalassotalea sp. …
Kojic acid reverses LPS-induced neuroinflammation and cognitive impairment by regulating the TLR4/NF-kappaB signaling pathway.
Ali W, Choe K, Park JS, Ahmad R, Park HY, Kang MH, Park TJ, Kim MO. Ali W, et al. Front Pharmacol. 2024 Aug 9;15:1443552. doi: 10.3389/fphar.2024.1443552. eCollection 2024. Front Pharmacol. 2024. PMID: 39185307 Free PMC article.
This study aims to evaluate the anti-inflammatory and antioxidant effect of kojic acid against the toxic effects of LPSs, such as neuroinflammation-induced neurodegeneration and cognitive decline. ...Intraperitoneal injection of LPS triggers the toll-like receptor 4 (TLR4) …
This study aims to evaluate the anti-inflammatory and antioxidant effect of kojic acid against the toxic effects of LPSs, such as neu …
Early immune events during SARS-CoV-2 infection impact memory T and B cell responses.
Woloszczuk K, Joyner D, Connors J, Bernui M, Canziani G, Chaiken I, Burger J, van Gils MJ, van Rijswijk J, Olijhoek W, Venkateswaren KV, Venkateswaran N, Bosinger SE, Eckalbar W, Altman MC, van Bakel H, Steen H, Diray-Arce J, Levy O, Maecker HT, Kim-Schulze S, Ozonoff A; IMPACC Network; Sekaly RP, Sanders RW, Kutzler MA, Cairns CB, Fourati S, Haddad EK. Woloszczuk K, et al. Commun Biol. 2026 Jun 5. doi: 10.1038/s42003-026-09927-x. Online ahead of print. Commun Biol. 2026. PMID: 42249109 Free article.
Immune responses elicited by natural infection of the coronavirus SARS-CoV-2 (COVID-19) show significant heterogeneity in the magnitude and quality of memory T and B cell responses. However, little is known about the contributing factors. In this study, we investigated the …
Immune responses elicited by natural infection of the coronavirus SARS-CoV-2 (COVID-19) show significant heterogeneity in the magnitude and …
Click linker: efficient and high yielding synthesis of a new family of kojic acid congeners as cytotoxic agents.
Ravirala S, Sura MB, Murugesan P, Tangutur AD, Ponnapalli MG. Ravirala S, et al. Nat Prod Res. 2023 Apr;37(7):1161-1167. doi: 10.1080/14786419.2021.1998897. Epub 2021 Oct 31. Nat Prod Res. 2023. PMID: 34720015
Preliminary studies on structure-activity-relationship (SAR) revealed that substitution at C-2 of kojic acid as well as C-5 of 1,2,3-triazole motif played a major role in the activity profile. Kojic acid 1,2,3-triazole analogue 3 b containing an alkyl chain ( …
Preliminary studies on structure-activity-relationship (SAR) revealed that substitution at C-2 of kojic acid as well as C-5 of 1,2,3- …
46 results